TXTP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TXTP_MOUSE
• UniProt AC: Q8JZU2
• Protein Name: Tricarboxylate transport protein, mitochondrial {ECO:0000250|UniProtKB:P53007}
• Gene Name: Slc25a1 {ECO:0000312|MGI:MGI:1345283}
• Organism: Mus musculus (Mouse).
• Sequence Length: 311
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein .
• Protein Description: Involved in citrate-H(+)/malate exchange. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway..
• Protein Sequence: MAAPRGPRALSAAAPGSGKPKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERANPPRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSRRGLLCGLGAGVAEAVVVVCPMETIKVKFIHDQTSSNPKYRGFFHGVREIIREQGLKGTYQGLTATVLKQGSNQAIRFFVMTSLRNWYQGDNHNKPMNPLITGVFGATAGAASVFGNTPLDVIKTRMQGLEAHKYRNTLDCGLKILKNEGPKAFYKGTVPRLGRVCLDVAIVFIIYDEVVKLLNKVWKTD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	PRGPRALSAAAPGSG CCCCCCCCCCCCCCC		26060331
70	S-palmitoylation	RYRGIGDCVRQTVRS CCCCHHHHHHHHHHH		26165157
77	Phosphorylation	CVRQTVRSHGVLGLY HHHHHHHHCCHHHHH		-
97	Acetylation	LLYGSIPKAAVRFGM HHHCCCCHHHHHHHH		23864654
97	Malonylation	LLYGSIPKAAVRFGM HHHCCCCHHHHHHHH		25418362
145	Phosphorylation	VVVCPMETIKVKFIH EEECCCCEEEEEEEE		29899451
149	Acetylation	PMETIKVKFIHDQTS CCCEEEEEEEECCCC		23201123
155	Phosphorylation	VKFIHDQTSSNPKYR EEEEECCCCCCHHHC		23684622
156	Phosphorylation	KFIHDQTSSNPKYRG EEEECCCCCCHHHCC		23684622
157	Phosphorylation	FIHDQTSSNPKYRGF EEECCCCCCHHHCCH		30352176
160	Acetylation	DQTSSNPKYRGFFHG CCCCCCHHHCCHHHH		23864654
160	Ubiquitination	DQTSSNPKYRGFFHG CCCCCCHHHCCHHHH		22790023
178	Ubiquitination	IIREQGLKGTYQGLT HHHHCCCCCCCCCEE		22790023
178	Acetylation	IIREQGLKGTYQGLT HHHHCCCCCCCCCEE		2415271
190	Acetylation	GLTATVLKQGSNQAI CEEEEEECCCCCHHH		23864654
216	Acetylation	YQGDNHNKPMNPLIT HCCCCCCCCCCHHHH		23954790
255	Acetylation	MQGLEAHKYRNTLDC HCHHHHHHHHCCHHH		23864654
255	Malonylation	MQGLEAHKYRNTLDC HCHHHHHHHHCCHHH		26320211
262	S-palmitoylation	KYRNTLDCGLKILKN HHHCCHHHCCHHHHC		26165157
265	Acetylation	NTLDCGLKILKNEGP CCHHHCCHHHHCCCC		23864654
265	Ubiquitination	NTLDCGLKILKNEGP CCHHHCCHHHHCCCC		22790023
268	Succinylation	DCGLKILKNEGPKAF HHCCHHHHCCCCCCC		23806337
268	Acetylation	DCGLKILKNEGPKAF HHCCHHHHCCCCCCC		23864654
276	Phosphorylation	NEGPKAFYKGTVPRL CCCCCCCCCCCCCCH		29514104
277	Acetylation	EGPKAFYKGTVPRLG CCCCCCCCCCCCCHH		23806337
277	Succinylation	EGPKAFYKGTVPRLG CCCCCCCCCCCCCHH		23806337

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TXTP_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TXTP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TXTP_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TXTP_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.