PRDX3_MOUSE - dbPTM
PRDX3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PRDX3_MOUSE
UniProt AC P20108
Protein Name Thioredoxin-dependent peroxide reductase, mitochondrial
Gene Name Prdx3
Organism Mus musculus (Mouse).
Sequence Length 257
Subcellular Localization Mitochondrion . Cytoplasm . Early endosome . Localizes to early endosomes in a RPS6KC1-dependent manner.
Protein Description Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides..
Protein Sequence MAAAAGRLLWSSVARHASAISRSISASTVLRPVASRRTCLTDILWSASAQGKSAFSTSSSFHTPAVTQHAPYFKGTAVVNGEFKELSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNITLLSDITKQISRDYGVLLESAGIALRGLFIIDPNGVVKHLSVNDLPVGRSVEETLRLVKAFQFVETHGEVCPANWTPESPTIKPSPTASKEYFEKVHQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
74AcetylationTQHAPYFKGTAVVNG
ECCCCCCCCEEEECC		49.8923576753
84SuccinylationAVVNGEFKELSLDDF
EEECCEEEEEECHHC		54.14-
84AcetylationAVVNGEFKELSLDDF
EEECCEEEEEECHHC		54.1423864654
84SuccinylationAVVNGEFKELSLDDF
EEECCEEEEEECHHC		54.1423806337
92AcetylationELSLDDFKGKYLVLF
EEECHHCCCCEEEEE		62.5823576753
92SuccinylationELSLDDFKGKYLVLF
EEECHHCCCCEEEEE		62.58-
92UbiquitinationELSLDDFKGKYLVLF
EEECHHCCCCEEEEE		62.58-
92SuccinylationELSLDDFKGKYLVLF
EEECHHCCCCEEEEE		62.5823806337
147PhosphorylationSHLAWINTPRKNGGL
CEEEEECCCCCCCCC		18.48-
150AcetylationAWINTPRKNGGLGHM
EEECCCCCCCCCCCC		62.2323576753
197AcetylationIDPNGVVKHLSVNDL
ECCCCCEEEEECCCC		36.1023954790
200PhosphorylationNGVVKHLSVNDLPVG
CCCEEEEECCCCCCC		20.70-
230S-nitrosylationVETHGEVCPANWTPE
HHHCCCCCCCCCCCC		1.9924895380
230GlutathionylationVETHGEVCPANWTPE
HHHCCCCCCCCCCCC		1.9924333276
230S-nitrosocysteineVETHGEVCPANWTPE
HHHCCCCCCCCCCCC		1.99-
235PhosphorylationEVCPANWTPESPTIK
CCCCCCCCCCCCCCC		19.5826745281
238PhosphorylationPANWTPESPTIKPSP
CCCCCCCCCCCCCCC		28.6626745281
240PhosphorylationNWTPESPTIKPSPTA
CCCCCCCCCCCCCCC		51.4126745281
242AcetylationTPESPTIKPSPTASK
CCCCCCCCCCCCCCH		41.7523864654
244PhosphorylationESPTIKPSPTASKEY
CCCCCCCCCCCCHHH		29.8523684622
246PhosphorylationPTIKPSPTASKEYFE
CCCCCCCCCCHHHHH		48.1526060331
249AcetylationKPSPTASKEYFEKVH
CCCCCCCHHHHHHHC		54.7023576753
254AcetylationASKEYFEKVHQ----
CCHHHHHHHCC----		34.8123806337
254UbiquitinationASKEYFEKVHQ----
CCHHHHHHHCC----		34.81-
254SuccinylationASKEYFEKVHQ----
CCHHHHHHHCC----		34.81-
254MalonylationASKEYFEKVHQ----
CCHHHHHHHCC----		34.8126320211
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PRDX3_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PRDX3_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PRDX3_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PRDX3_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PRDX3_MOUSE

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Related Literatures of Post-Translational Modification

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