SAHH_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SAHH_MOUSE
• UniProt AC: P50247
• Protein Name: Adenosylhomocysteinase
• Gene Name: Ahcy
• Organism: Mus musculus (Mouse).
• Sequence Length: 432
• Subcellular Localization: Cytoplasm. Melanosome.
• Protein Description: Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine..
• Protein Sequence: MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKYPQLLSGIRGISEETTTGVHNLYKMMSNGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYWLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSDKLPYKV ------CCCCCCCCH	43.37	-
2	Phosphorylation	------MSDKLPYKV ------CCCCCCCCH	43.37	21743459
4	Acetylation	----MSDKLPYKVAD ----CCCCCCCCHHH	44.02	22733758
4	Malonylation	----MSDKLPYKVAD ----CCCCCCCCHHH	44.02	26320211
8	Acetylation	MSDKLPYKVADIGLA CCCCCCCCHHHHHHH	29.07	23806337
8	Ubiquitination	MSDKLPYKVADIGLA CCCCCCCCHHHHHHH	29.07	-
8	Succinylation	MSDKLPYKVADIGLA CCCCCCCCHHHHHHH	29.07	23806337
20	Ubiquitination	GLAAWGRKALDIAEN HHHHCHHHHHHHHHC	49.73	-
20	Malonylation	GLAAWGRKALDIAEN HHHHCHHHHHHHHHC	49.73	26320211
43	Acetylation	REMYSASKPLKGARI HHHHHCCCCCCCCCC	54.83	22826441
43	Ubiquitination	REMYSASKPLKGARI HHHHHCCCCCCCCCC	54.83	-
43	Malonylation	REMYSASKPLKGARI HHHHHCCCCCCCCCC	54.83	26320211
46	Ubiquitination	YSASKPLKGARIAGC HHCCCCCCCCCCHHH	60.08	-
46	Malonylation	YSASKPLKGARIAGC HHCCCCCCCCCCHHH	60.08	26320211
79	S-palmitoylation	AEVRWSSCNIFSTQD CEEEECCCCCCCCHH	3.65	28526873
113	S-palmitoylation	TDEEYLWCIEQTLHF CCHHHHHHHEEEEEC	1.96	28526873
142	Acetylation	LTNLIHTKYPQLLSG HHHHHHHCCHHHHHC	40.55	23954790
148	Phosphorylation	TKYPQLLSGIRGISE HCCHHHHHCCCCCCC	40.54	30352176
158	Phosphorylation	RGISEETTTGVHNLY CCCCCCCCCHHHHHH	25.49	30352176
166	Acetylation	TGVHNLYKMMSNGIL CHHHHHHHHHHCCCE	31.15	23954790
166	Ubiquitination	TGVHNLYKMMSNGIL CHHHHHHHHHHCCCE	31.15	22790023
174	Acetylation	MMSNGILKVPAINVN HHHCCCEEECEEECC	44.23	22902405
174	Ubiquitination	MMSNGILKVPAINVN HHHCCCEEECEEECC	44.23	22790023
183	Phosphorylation	PAINVNDSVTKSKFD CEEECCCCCCHHHCC	26.87	25521595
185	Phosphorylation	INVNDSVTKSKFDNL EECCCCCCHHHCCCC	33.29	21743459
186	Ubiquitination	NVNDSVTKSKFDNLY ECCCCCCHHHCCCCC	49.87	-
186	Malonylation	NVNDSVTKSKFDNLY ECCCCCCHHHCCCCC	49.87	25418362
186	Acetylation	NVNDSVTKSKFDNLY ECCCCCCHHHCCCCC	49.87	23954790
187	Phosphorylation	VNDSVTKSKFDNLYG CCCCCCHHHCCCCCC	29.23	25367039
188	Ubiquitination	NDSVTKSKFDNLYGC CCCCCHHHCCCCCCH	59.29	22790023
188	Acetylation	NDSVTKSKFDNLYGC CCCCCHHHCCCCCCH	59.29	23201123
193	Phosphorylation	KSKFDNLYGCRESLI HHHCCCCCCHHHHHH	22.04	25521595
195	S-nitrosocysteine	KFDNLYGCRESLIDG HCCCCCCHHHHHHHH	2.49	-
195	S-palmitoylation	KFDNLYGCRESLIDG HCCCCCCHHHHHHHH	2.49	28526873
195	S-nitrosylation	KFDNLYGCRESLIDG HCCCCCCHHHHHHHH	2.49	22178444
195	Glutathionylation	KFDNLYGCRESLIDG HCCCCCCHHHHHHHH	2.49	24333276
198	Phosphorylation	NLYGCRESLIDGIKR CCCCHHHHHHHHHHH	15.98	22324799
204	Succinylation	ESLIDGIKRATDVMI HHHHHHHHHHHHCEE	41.32	23954790
204	Ubiquitination	ESLIDGIKRATDVMI HHHHHHHHHHHHCEE	41.32	-
226	Malonylation	AGYGDVGKGCAQALR ECCCHHHHHHHHHHH	51.14	25418362
226	Ubiquitination	AGYGDVGKGCAQALR ECCCHHHHHHHHHHH	51.14	-
228	S-nitrosylation	YGDVGKGCAQALRGF CCHHHHHHHHHHHHC	2.64	22178444
266	S-palmitoylation	VTTMDEACKEGNIFV EEEHHHHHHCCCEEE	3.76	28526873
318	Acetylation	LNENAVEKVNIKPQV CCCCCEEECCCCCCC	33.70	22826441
318	Ubiquitination	LNENAVEKVNIKPQV CCCCCEEECCCCCCC	33.70	-
318	Malonylation	LNENAVEKVNIKPQV CCCCCEEECCCCCCC	33.70	26320211
322	Ubiquitination	AVEKVNIKPQVDRYW CEEECCCCCCCEEEE	24.97	-
322	Succinylation	AVEKVNIKPQVDRYW CEEECCCCCCCEEEE	24.97	23954790
322	Acetylation	AVEKVNIKPQVDRYW CEEECCCCCCCEEEE	24.97	23954790
331	Malonylation	QVDRYWLKNGRRIIL CCEEEEECCCCEEEE	43.12	26320211
331	Ubiquitination	QVDRYWLKNGRRIIL CCEEEEECCCCEEEE	43.12	-
331	Acetylation	QVDRYWLKNGRRIIL CCEEEEECCCCEEEE	43.12	23864654
389	Malonylation	GVHFLPKKLDEAVAE CEEECCHHHHHHHHH	60.27	26320211
389	Ubiquitination	GVHFLPKKLDEAVAE CEEECCHHHHHHHHH	60.27	-
401	Ubiquitination	VAEAHLGKLNVKLTK HHHHHHCHHHHHHEE	43.16	22790023
401	Acetylation	VAEAHLGKLNVKLTK HHHHHHCHHHHHHEE	43.16	23954790
405	Malonylation	HLGKLNVKLTKLTEK HHCHHHHHHEECCHH	49.73	26320211
405	Ubiquitination	HLGKLNVKLTKLTEK HHCHHHHHHEECCHH	49.73	-
408	Malonylation	KLNVKLTKLTEKQAQ HHHHHHEECCHHHHH	64.94	26320211
408	Acetylation	KLNVKLTKLTEKQAQ HHHHHHEECCHHHHH	64.94	23201123
412	Malonylation	KLTKLTEKQAQYLGM HHEECCHHHHHHCCC	45.78	26320211
412	Acetylation	KLTKLTEKQAQYLGM HHEECCHHHHHHCCC	45.78	23954790
412	Ubiquitination	KLTKLTEKQAQYLGM HHEECCHHHHHHCCC	45.78	-
416	Phosphorylation	LTEKQAQYLGMPING CCHHHHHHCCCCCCC	14.29	17242355
426	Ubiquitination	MPINGPFKPDHYRY- CCCCCCCCCCCCCC-	53.31	22790023
426	Acetylation	MPINGPFKPDHYRY- CCCCCCCCCCCCCC-	53.31	23954790

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SAHH_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SAHH_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SAHH_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SAHH_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.