MYOM3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYOM3_MOUSE
• UniProt AC: A2ABU4
• Protein Name: Myomesin-3
• Gene Name: Myom3
• Organism: Mus musculus (Mouse).
• Sequence Length: 1439
• Subcellular Localization: Cytoplasm, myofibril, sarcomere, M line .
• Protein Description: May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle..
• Protein Sequence: MTLPHSPGSAGEPQASQTVQVHRLEHRQEEEQKEERQHSLQMGSSVQRRTYRSSEEEQQFSSEDYALAAALALTASSELSWEAKLRRQTTTVELEERGQRRVGFGNDLERMELAFLRTQRLLRQRRDWKALRQRTEEKVREAKELIELCSGRGPWFWIPLRSHAVWEHTTVLLTCTVQGSPPFQVTWYKNDIRIDPRLFPAGKYRITNNYGLLTLEIMRCTVEDSATYTVLVKNAYGQASSFAKVLIRNYLGKDAGFDSEIFKRSMFGPSAEFTSVLKPIFAQEKEPFSLTCLFSDDVLEAEQRIQWYRDGRLLRSSTRRQILYADRQASVKVSCAYKEDEGFYTIRVSSPFGPQEQSAYVFIRDAAAEKPGAPGSPLNVRCLNVHRDCLTLTWVPPSDTRGSTITGYSIEMCQGDSEEWMPCLKAPGGTCRCPIQGLVEGQSYQFRVRAISKAGTSLPSKASEAVVTGDYDAVHKSTEIPYDLGSKITISKNDFEDAVTIPSAPTNVHASEIREAYAVLSWEEPRPRGRAPLTYTLEKSVIGSGTWEAISTETPIKSPRFALLDLEKGKSYVFRVRALNQYGMSDPSEPSEPVALKGKPATLPPPAQVQAFRNTQTSVSLAWEPVDGGSELLGYYIYSREAGASEWQTVNNKPIQDTKFTVPGLRTGKEYDFCIRSVSEAGVGESSAATQPVRVKQALATPSAPYDFALLNCGKNEMVIGWKPPKRRGGGKILGYFMDQHDSVESDWHPVNRQPIPSRVCKVTNLHEGHFYEFRARAVNWAGIGELSAPSSLFECKEWTMPEPGPPYDVRVSEVQATSVMLQWEPPLYIGAGPVTGYHVSFQEKGSEEWKPVTPDATSDTHLRVSDLQPGKQYMFRVQAMNSAGLGQPSVPTDPVLLEDKPDAQEIEVGVDDEGQIYLAFEAPEAPDFPEFQWSKDYQGPPDPQRVEVEDEISKSKVILKEPDLQDLGIYSVVVPDADEDTSASHTLTEEELNKLKKLSHEIRNPVIKLISGWNVEILEQGEVRLWLEVEKLSPAAELHLIFNEKEIFSSPNRKINFDREKGLVEVIIQQLSEDDKGSYTAQLQDGKAKNQITLALVDDEFDKLLRKADAKRRDWKRKQGPYFQEPLTWKVTDDCQVLLSCKVTNTKKESRFQWFFQKKEAPHGQYNPPTGDGSLSIEGFSKENQGVYRAVVSDERGEDDTVLDLTGEALDAVLTELGRIGALSATPLKIQGTEEGIRLFSKVKYYNVDYMKTAWFHKDKRLESGDRVRAGTTLDEIWLHILDPKDSDKGKYTLEITAGKEVRQLSADLSGQAFDDALAEHQRLKALAVIEKNRAKVVRGLPDVATIMEDKTLCLTCVISGDPSPEISWLKNDQPISFFDRYHMEVKGTEVTVTIDKVTSEDSGRYGIFVKNKYGSETGQVTISVFKHGEEPKELKKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTLPHSPGS ------CCCCCCCCC	61.37	28464351
6	Phosphorylation	--MTLPHSPGSAGEP --CCCCCCCCCCCCC	29.08	22418434
9	Phosphorylation	TLPHSPGSAGEPQAS CCCCCCCCCCCCCCC	36.16	28464351
39	Phosphorylation	QKEERQHSLQMGSSV HHHHHHHHHHHCHHH	16.38	19060867
45	Phosphorylation	HSLQMGSSVQRRTYR HHHHHCHHHHHHCCC	19.28	28464351
89	Phosphorylation	EAKLRRQTTTVELEE HHHHCCCCCEEEHHH	23.71	28464351
90	Phosphorylation	AKLRRQTTTVELEER HHHCCCCCEEEHHHH	22.10	28542873
240	Phosphorylation	KNAYGQASSFAKVLI ECCCCCHHHHHHHHH	20.35	28464351
259	Phosphorylation	GKDAGFDSEIFKRSM CCCCCCCHHHHHHHH	30.26	23375375
289	Phosphorylation	AQEKEPFSLTCLFSD CCCCCCEEEEEEECH	33.22	25338131
291	Phosphorylation	EKEPFSLTCLFSDDV CCCCEEEEEEECHHH	13.13	25338131
350	Phosphorylation	FYTIRVSSPFGPQEQ EEEEEEECCCCCHHH	22.76	28464351
370	Acetylation	IRDAAAEKPGAPGSP EEHHHCCCCCCCCCC	43.98	30987019
376	Phosphorylation	EKPGAPGSPLNVRCL CCCCCCCCCCCEEEE	25.75	28464351
477	Phosphorylation	DYDAVHKSTEIPYDL CCCCCCCCCCCCCCC	19.18	28464351
486	Phosphorylation	EIPYDLGSKITISKN CCCCCCCCCEEEECC	28.34	23140645
686	Phosphorylation	SEAGVGESSAATQPV HHCCCCCCCCCCCCC	21.24	28464351
1108	Acetylation	EFDKLLRKADAKRRD HHHHHHHHHHHHHCC	51.06	7711637
1265	Phosphorylation	HKDKRLESGDRVRAG ECCCCCCCCCCCCCC	51.06	-
1288	Phosphorylation	HILDPKDSDKGKYTL EECCCCCCCCCCEEE	47.55	22210690
1298	Phosphorylation	GKYTLEITAGKEVRQ CCEEEEEECCHHHEE	21.71	20139300
1307	Phosphorylation	GKEVRQLSADLSGQA CHHHEEECCCCCCCC	16.05	28464351
1311	Phosphorylation	RQLSADLSGQAFDDA EEECCCCCCCCHHHH	29.43	28464351
1333	Ubiquitination	KALAVIEKNRAKVVR HHHHHHHHHHHHHHC	40.38	-
1337	Ubiquitination	VIEKNRAKVVRGLPD HHHHHHHHHHCCCCC	37.72	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYOM3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYOM3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYOM3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MYOM3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.