SPCS2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPCS2_MOUSE
• UniProt AC: Q9CYN2
• Protein Name: Signal peptidase complex subunit 2
• Gene Name: Spcs2
• Organism: Mus musculus (Mouse).
• Sequence Length: 226
• Subcellular Localization: Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
• Protein Description: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum..
• Protein Sequence: MAASASQGGRSGGGGGSSGAGGGPSCGTSSSRSGLLDKWKIDDKPVKIDKWDGSAVKNSLDDSAKKVLLEKYKYVENFGLIDGRLTICTISCFFAIVALIWDYMHPFPESKPVLALCVISYFVMMGILTIYTSYKEKSIFLVAHRKDPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGRTKQQREAEFTKSIAKFFDHSGTLVMDAYEPEISRLHDSLATERKIK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAASASQGG ------CCCCCCCCC	15.32	16452087
4	Phosphorylation	----MAASASQGGRS ----CCCCCCCCCCC	20.93	27841257
6	Phosphorylation	--MAASASQGGRSGG --CCCCCCCCCCCCC	27.19	27841257
11	Phosphorylation	SASQGGRSGGGGGSS CCCCCCCCCCCCCCC	45.10	29472430
17	Phosphorylation	RSGGGGGSSGAGGGP CCCCCCCCCCCCCCC	28.95	22817900
18	Phosphorylation	SGGGGGSSGAGGGPS CCCCCCCCCCCCCCC	35.62	30635358
25	Phosphorylation	SGAGGGPSCGTSSSR CCCCCCCCCCCCCCC	28.58	22817900
28	Phosphorylation	GGGPSCGTSSSRSGL CCCCCCCCCCCCCCC	29.75	21183079
29	Phosphorylation	GGPSCGTSSSRSGLL CCCCCCCCCCCCCCC	16.17	23684622
30	Phosphorylation	GPSCGTSSSRSGLLD CCCCCCCCCCCCCCC	29.61	23984901
31	Phosphorylation	PSCGTSSSRSGLLDK CCCCCCCCCCCCCCC	30.17	23140645
33	Phosphorylation	CGTSSSRSGLLDKWK CCCCCCCCCCCCCCC	35.42	22982522
50	Malonylation	DKPVKIDKWDGSAVK CCCEEEEECCCHHHH	51.13	26320211
138	Phosphorylation	YTSYKEKSIFLVAHR HHHCCCCEEEEEEEC	21.47	22817900
162	Phosphorylation	DIWQLSSSLKRFDDK HHHHHHHHHCCCCCC	34.24	21082442
169	Acetylation	SLKRFDDKYTLKLTF HHCCCCCCEEEEEEE	41.81	23954790
169	Malonylation	SLKRFDDKYTLKLTF HHCCCCCCEEEEEEE	41.81	26320211
191	Acetylation	QREAEFTKSIAKFFD HHHHHHHHHHHHHHC	45.23	23806337
191	Malonylation	QREAEFTKSIAKFFD HHHHHHHHHHHHHHC	45.23	26320211
192	Phosphorylation	REAEFTKSIAKFFDH HHHHHHHHHHHHHCC	25.40	-
195	Acetylation	EFTKSIAKFFDHSGT HHHHHHHHHHCCCCC	44.91	23954790
218	Phosphorylation	EISRLHDSLATERKI HHHHHHHHHHHHCCC	14.79	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPCS2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPCS2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPCS2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BLMH_HUMAN	BLMH	physical	26496610
GANP_HUMAN	MCM3AP	physical	26496610
TTC37_HUMAN	TTC37	physical	26496610
SC11A_HUMAN	SEC11A	physical	26496610
PGAP2_HUMAN	PGAP2	physical	26496610
KI26B_HUMAN	KIF26B	physical	26496610
SPCS3_HUMAN	SPCS3	physical	26496610
F111B_HUMAN	FAM111B	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.