VCIP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VCIP1_MOUSE
• UniProt AC: Q8CDG3
• Protein Name: Deubiquitinating protein VCIP135
• Gene Name: Vcpip1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1220
• Subcellular Localization: Endoplasmic reticulum. Golgi apparatus, Golgi stack. Associated with Golgi stacks and endoplasmic reticulum..
• Protein Description: Acts as a deubiquitinating enzyme. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP. Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (By similarity)..
• Protein Sequence: MSQPPPPPPLPPPPPPPEAPQTSSSLAAAASPGGLSKRRDRRILSGSCPDPKCQARLFFPASGSVSIECTECGQRHEQQQLLGVEEVTDPDVVLHNLLRNALLGVTGAPKKNTELVKVMGLSNYHCKLLSPILARYGMDKQTGRAKLLRDMNQGELFDCALLGDRAFLIEPEHVNTVGYGKDRSGSLLYLHDTLEDIKRANKSQECLIPVHVDGDGHCLVHAVSRALVGRELFWHALRENLKQHFQQHLARYQALFHDFIDAAEWEDIINECDPLFVPPEGVPLGLRNIHIFGLANVLHRPIILLDSLSGMRSSGDYSATFLPGLIPAEKCTGRDGHLNKPICIAWSSSGRNHYIPLVGIKGAALPKLPMNLLPKAWGVPQDLIKKYIKLEEDGGCVIGGDRSLQDKYLLRLVAAMEEVFMDKHGIHPSLVADVHQYFYRRTGVIGVQPEEVTAAAKKAVMDNRLHKCLLYGALSELHVPSEWLAPGGKLYNLAKSTHGQLRPDKNYSFPLNNLVCSYDPVKDVLLPDYGLSNLTACNWCHGSSVRRVRGDGSIVYLDGDRTNSRSTGGKCGCGFKHFWEGKEYDNLPEAFPITLEWGGRVVRETVYWFQYESDPSLNSNVYDVAMKLVTKHFPGEFGSEILVQKVVHTILHQTAKKNPDDYTPVNIDGAHAQRVGDVQGQELESQLPTKIILTGQKTKTLHKEELNMSKTERTIQQNITEQASVMQKRKTEKLKQEQKGQPRTVSPSTIRDGPSSAPATPTKAPYSPTTSKEKKIRITTNDGRQSMVTLKPSTTFFELQESIAREFNIPPYLQCIRYGFPPKELMPPQAGMEKEPVPLQHGDRITIEILKGRAEGGPSTAAHSAHTVKQEEIAVTGKLSSKELQEQADKEMYSLCLLATLMGEDVWSYAKGLPHMFQQGGVFYNIMKKTMGMADGKHCTFPHLPGKTFVYNASEDRLELCVDAAGHFPIGPDVEDLVKEAVSQVRAEATTRSRESSPSHGLLKLGSGGVVKKKSEQLHNVTAFQGKGHSLGTASSHPHIDPRARETLAVRKHNTGTDFSNSSIKTEPPVFTAASSNSELIRIAPGVVTMRDGRQIDPDVVEAQRKKLQEMVSSIQASMDKHLRDQSAEQAPSDLSQRKVEVVSSVRPVNLQTGLPEPFSLTGGTENLNTETTDSHVADVLGAAFATRSKAQKENSMEEPEEMDSQDAETTNTTEPMDHS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	SSLAAAASPGGLSKR CHHHHHCCCCCCCHH	21.25	30482847
36	Phosphorylation	AASPGGLSKRRDRRI HCCCCCCCHHHCCCC	27.65	25293948
45	Phosphorylation	RRDRRILSGSCPDPK HHCCCCCCCCCCCCC	26.70	30635358
47	Phosphorylation	DRRILSGSCPDPKCQ CCCCCCCCCCCCCCC	21.07	30635358
130	Phosphorylation	NYHCKLLSPILARYG CHHHHHHHHHHHHHC	21.96	29514104
144	Dimethylation	GMDKQTGRAKLLRDM CCCCCCCHHHHHHHC	31.75	-
144	Methylation	GMDKQTGRAKLLRDM CCCCCCCHHHHHHHC	31.75	18965123
149	Dimethylation	TGRAKLLRDMNQGEL CCHHHHHHHCCCCCC	52.12	-
149	Methylation	TGRAKLLRDMNQGEL CCHHHHHHHCCCCCC	52.12	18965133
181	Ubiquitination	VNTVGYGKDRSGSLL CCCCCCCCCCCCCEE	41.29	-
186	Phosphorylation	YGKDRSGSLLYLHDT CCCCCCCCEEEEECC	19.22	22817900
317	Phosphorylation	GMRSSGDYSATFLPG CCCCCCCCCCCCCCC	12.06	-
330	Ubiquitination	PGLIPAEKCTGRDGH CCCCCHHHCCCCCCC	38.92	-
361	Ubiquitination	YIPLVGIKGAALPKL EEEEEEECCCCCCCC	36.25	-
407	Acetylation	GDRSLQDKYLLRLVA CCCHHCHHHHHHHHH	25.49	-
407	Ubiquitination	GDRSLQDKYLLRLVA CCCHHCHHHHHHHHH	25.49	-
662	Phosphorylation	AKKNPDDYTPVNIDG HHHCCCCCCCCCCCC	21.96	29514104
690	Ubiquitination	LESQLPTKIILTGQK HHHCCCCEEEEECCC	26.30	-
728	Ubiquitination	EQASVMQKRKTEKLK HHHHHHHHHHHHHHH	37.45	-
744	Phosphorylation	EQKGQPRTVSPSTIR HHCCCCCCCCCCCCC	31.83	24925903
746	Phosphorylation	KGQPRTVSPSTIRDG CCCCCCCCCCCCCCC	16.72	24925903
748	Phosphorylation	QPRTVSPSTIRDGPS CCCCCCCCCCCCCCC	29.03	24925903
749	Phosphorylation	PRTVSPSTIRDGPSS CCCCCCCCCCCCCCC	24.34	28833060
755	Phosphorylation	STIRDGPSSAPATPT CCCCCCCCCCCCCCC	44.66	27149854
756	Phosphorylation	TIRDGPSSAPATPTK CCCCCCCCCCCCCCC	41.21	25521595
760	Phosphorylation	GPSSAPATPTKAPYS CCCCCCCCCCCCCCC	30.36	25521595
762	Phosphorylation	SSAPATPTKAPYSPT CCCCCCCCCCCCCCC	35.17	21082442
766	Phosphorylation	ATPTKAPYSPTTSKE CCCCCCCCCCCCCCC	31.94	25619855
767	Phosphorylation	TPTKAPYSPTTSKEK CCCCCCCCCCCCCCC	18.08	25521595
769	Phosphorylation	TKAPYSPTTSKEKKI CCCCCCCCCCCCCEE	37.45	28542873
770	Phosphorylation	KAPYSPTTSKEKKIR CCCCCCCCCCCCEEE	40.98	21082442
771	Phosphorylation	APYSPTTSKEKKIRI CCCCCCCCCCCEEEE	41.10	21082442
990	Phosphorylation	SQVRAEATTRSRESS HHHHHHHHCCCCCCC	17.78	26643407
991	Phosphorylation	QVRAEATTRSRESSP HHHHHHHCCCCCCCC	33.42	26643407
993	Phosphorylation	RAEATTRSRESSPSH HHHHHCCCCCCCCCC	38.00	26824392
996	Phosphorylation	ATTRSRESSPSHGLL HHCCCCCCCCCCCCE	46.57	26824392
997	Phosphorylation	TTRSRESSPSHGLLK HCCCCCCCCCCCCEE	26.18	25521595
999	Phosphorylation	RSRESSPSHGLLKLG CCCCCCCCCCCEECC	31.94	27742792
1012	Ubiquitination	LGSGGVVKKKSEQLH CCCCCEEECCHHHHC	52.67	-
1063	Phosphorylation	GTDFSNSSIKTEPPV CCCCCCCCCCCCCCE	32.14	27841257
1072	O-linked_Glycosylation	KTEPPVFTAASSNSE CCCCCEEEECCCCCC	22.88	55414569
1072	Phosphorylation	KTEPPVFTAASSNSE CCCCCEEEECCCCCC	22.88	22871156
1075	O-linked_Glycosylation	PPVFTAASSNSELIR CCEEEECCCCCCCEE	27.82	22517741
1076	Phosphorylation	PVFTAASSNSELIRI CEEEECCCCCCCEEE	39.38	30352176
1078	Phosphorylation	FTAASSNSELIRIAP EEECCCCCCCEEECC	35.41	22871156
1107	Ubiquitination	VVEAQRKKLQEMVSS HHHHHHHHHHHHHHH	58.55	-
1118	Phosphorylation	MVSSIQASMDKHLRD HHHHHHHHHHHHHHH	15.90	26643407
1127	Phosphorylation	DKHLRDQSAEQAPSD HHHHHHCCHHHCCCC	37.75	29899451
1136	Phosphorylation	EQAPSDLSQRKVEVV HHCCCCHHHCCEEEE	32.69	-
1189	Phosphorylation	GAAFATRSKAQKENS HHHHHHHHHHHHHCC	28.17	30635358
1196	Phosphorylation	SKAQKENSMEEPEEM HHHHHHCCCCCCHHH	28.76	25521595
1205	Phosphorylation	EEPEEMDSQDAETTN CCCHHHCCCCCCCCC	28.75	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VCIP1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1205	S	Phosphorylation	Phosphorylated at Ser-1205 by ATM or ATR following induction of covalent DNA-protein cross-links (DPCs).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VCIP1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TERA_HUMAN	VCP	physical	26496610
ALMS1_HUMAN	ALMS1	physical	26496610
HUWE1_HUMAN	HUWE1	physical	26496610
CE162_HUMAN	CEP162	physical	26496610
CCHCR_HUMAN	CCHCR1	physical	26496610
K2013_HUMAN	KIAA2013	physical	26496610
NPHP4_HUMAN	NPHP4	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.