CHP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CHP1_MOUSE
• UniProt AC: P61022
• Protein Name: Calcineurin B homologous protein 1
• Gene Name: Chp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 195
• Subcellular Localization: Nucleus . Cytoplasm . Cytoplasm, cytoskeleton . Endomembrane system . Endoplasmic reticulum-Golgi intermediate compartment . Endoplasmic reticulum . Cell membrane . Membrane ; Lipid-anchor . Localizes in cytoplasmic compartments in dividing cells. Lo
• Protein Description: Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membranes. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner (By similarity)..
• Protein Sequence: MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAINPLGDRIINAFFSEGEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFRLYDLDKDDKISRDELLQVLRMMVGVNISDEQLGSIADRTIQEADQDGDSAISFTEFVKVLEKVDVEQKMSIRFLH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGSRASTLL ------CCCHHHHHC	26.32	-
6	Phosphorylation	--MGSRASTLLRDEE --CCCHHHHHCCHHH	20.62	25159016
7	Phosphorylation	-MGSRASTLLRDEEL -CCCHHHHHCCHHHH	28.91	26824392
19	Ubiquitination	EELEEIKKETGFSHS HHHHHHHHHHCCCHH	67.19	27667366
21	Phosphorylation	LEEIKKETGFSHSQI HHHHHHHHCCCHHHH	53.02	27681418
24	Phosphorylation	IKKETGFSHSQITRL HHHHHCCCHHHHHHH	24.47	23684622
26	Phosphorylation	KETGFSHSQITRLYS HHHCCCHHHHHHHHH	23.29	23684622
29	Phosphorylation	GFSHSQITRLYSRFT CCCHHHHHHHHHHHH	13.64	28066266
33	Phosphorylation	SQITRLYSRFTSLDK HHHHHHHHHHHCCCC	26.05	25338131
37	Phosphorylation	RLYSRFTSLDKGENG HHHHHHHCCCCCCCC	31.68	25338131
40	Ubiquitination	SRFTSLDKGENGTLS HHHHCCCCCCCCCCC	73.71	-
100	Ubiquitination	IEDNEKSKDVNGPEP CCCCCCCCCCCCCCC	76.42	27667366
114	Ubiquitination	PLNSRSNKLHFAFRL CCCCCCCCCEEEEEE	44.58	-
169	Phosphorylation	EADQDGDSAISFTEF HHCCCCCCCEEHHHH	32.79	30635358
172	Phosphorylation	QDGDSAISFTEFVKV CCCCCCEEHHHHHHH	26.32	30635358
174	Phosphorylation	GDSAISFTEFVKVLE CCCCEEHHHHHHHHH	23.02	30635358
182	Ubiquitination	EFVKVLEKVDVEQKM HHHHHHHHCCHHHHH	39.30	-
188	Ubiquitination	EKVDVEQKMSIRFLH HHCCHHHHHHCEECC	22.55	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CHP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CHP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CHP1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CHP1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.