OPLA_MOUSE - dbPTM
OPLA_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID OPLA_MOUSE
UniProt AC Q8K010
Protein Name 5-oxoprolinase
Gene Name Oplah
Organism Mus musculus (Mouse).
Sequence Length 1288
Subcellular Localization
Protein Description Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate..
Protein Sequence MGSPEERFHFAIDRGGTFTDVFAQCPGGHVRVLKLLSEDPANYADAPTEGIRRILEQERGVLLPRGRPLDTSHIASIRMGTTVATNALLERQGERVALLVTRGFRDLLHIGTQARPDLFDLAVPMPEVLYEEVVEVDERVLLYRGEPGAGSPVKGCTGDLLEIQQPVDLAALRGKLEGLLTRGIHSLAVVLMHSYTWAQHEQQVGTLARELGFTHVSLSSEVMPMVRIVPRGHTACADAYLTPTIQRYVQGFRRGFQGQLKNVQVLFMRSDGGLAPMDAFSGSRAVLSGPAGGVVGYSTTTYQLEGGQPVIGFDMGGTSTDVSRYAGEFEHVFEASTAGVTLQAPQLDINTVAAGGGSRLFFRSGLFVVGPESAGAHPGPACYRKGGPVTVTDANLVLGRLLPASFPCIFGPGEDQPLSPEASRKALEAVAMEVNSFLASGPCPASQLSLEEVAMGFVRVANEAMCRPIRALTQARGHDPSAHVLACFGGAGGQHACAIARALGMDTVHIHRHSGLLSALGLALADVVHEAQEPCSLSYTPETFAQLDQRLSRLEEQCVDALQAQGFSRSQISTESFLHLRYQGTDCALMVSANQHPATTCSPRAGDFGAAFVERYMREFGFIIPERSVVVDDVRVRGTGRSGLQLEETSKIQSGPPHVEKVTQCYFEGGYQETPVYLLGELGYGHQLQGPCLIIDNNSTILVEPGCQAEVIETGDIRISVGAEAPSMIDTKLDPIQLSIFSHRFMSIAEQMGRILQRTAISTNIKERLDFSCALFGPDGGLVSNAPHIPVHLGAMQETVQFQIQHLGADLHPGDVLLSNHPSAGGSHLPDLTVITPVFWPGQSRPVFYVASRGHHADIGGITPGSMPPHSTTLQQEGAVFLSFKLVQGGVFQEEAVTEALQAPGKISGCSGTRNLHDNLSDLRAQVAANQKGIQLVGELIGQYGLDVVQAYMGHIQANAELAVRDMLRAFGTSRQARGLPLEVSAKDHMDDGSPICLHVQINLNQGSAVFDFSGSGSEVFGNLNAPRAITLSALIYCLRCLVGRDIPLNQGCLAPVQVIIPKGSILDPSPEAAVVGGNVLTSQRVVDVILGAFGACAASQGCMNNVTLGNARMGYYETVAGGAGAGPGWHGRSGVHSHMTNTRITDPEILESRYPVILRRFELRPGSGGRGRFRGGDGVVRELVFREEALLSVLTERRAFQPYGLHGGEPGTRGLNLLIRKDGRTVNLGGKTSVTVYPGDAFCLHTPGGGGYGDPEDPAPPPGSPPLYPAFPERGSVYEYRRAQEAV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MGSPEERFHF
-----CCCHHHHHEE		40.7826643407
17PhosphorylationFAIDRGGTFTDVFAQ
EEEECCCCEEEHHHC		26.6223984901
19PhosphorylationIDRGGTFTDVFAQCP
EECCCCEEEHHHCCC		30.9623984901
34UbiquitinationGGHVRVLKLLSEDPA
CCCEEEEEECCCCCC		44.5222790023
151PhosphorylationRGEPGAGSPVKGCTG
CCCCCCCCCCCCCCC		26.4526643407
154UbiquitinationPGAGSPVKGCTGDLL
CCCCCCCCCCCCCCE		52.2122790023
156S-palmitoylationAGSPVKGCTGDLLEI
CCCCCCCCCCCCEEE		2.9728526873
175UbiquitinationDLAALRGKLEGLLTR
CHHHHHHHHHHHHHC		36.6122790023
217PhosphorylationELGFTHVSLSSEVMP
HHCCCEEECCCCEEC		18.22-
382S-palmitoylationGAHPGPACYRKGGPV
CCCCCCCCCCCCCCE		3.6728526873
385UbiquitinationPGPACYRKGGPVTVT
CCCCCCCCCCCEEEC		41.5722790023
408S-palmitoylationLLPASFPCIFGPGED
CCCCCCCEEECCCCC		3.6628526873
419PhosphorylationPGEDQPLSPEASRKA
CCCCCCCCHHHHHHH		27.6429899451
423PhosphorylationQPLSPEASRKALEAV
CCCCHHHHHHHHHHH		32.4329899451
466S-palmitoylationRVANEAMCRPIRALT
HHHHHHHHHHHHHHH		6.3626165157
497S-nitrosylationGAGGQHACAIARALG
CCCHHHHHHHHHHHC		2.3622178444
570PhosphorylationQAQGFSRSQISTESF
HHCCCCHHHCCCCCE		30.5719060867
628PhosphorylationGFIIPERSVVVDDVR
CCEECCCCEEEEEEE		20.0129899451
639PhosphorylationDDVRVRGTGRSGLQL
EEEEECCCCCCCCCC		20.8921454597
651UbiquitinationLQLEETSKIQSGPPH
CCCEECCCCCCCCCC		52.7822790023
654PhosphorylationEETSKIQSGPPHVEK
EECCCCCCCCCCHHH		57.6623684622
732UbiquitinationAPSMIDTKLDPIQLS
CCCHHCCCCCHHHHH		47.3322790023
739PhosphorylationKLDPIQLSIFSHRFM
CCCHHHHHHHHHHHH		12.7626239621
766UbiquitinationTAISTNIKERLDFSC
HHHCCCHHHHCCEEE		38.5622790023
806UbiquitinationTVQFQIQHLGADLHP
HHHHHHHHCCCCCCC		28.0627667366
862UbiquitinationHHADIGGITPGSMPP
CCCCCCCCCCCCCCC		3.3727667366
906UbiquitinationEALQAPGKISGCSGT
HHHHCCCCCCCCCCC		32.4122790023
1053S-palmitoylationDIPLNQGCLAPVQVI
CCCCCCCCCCCEEEE		1.7928526873
1144MethylationHSHMTNTRITDPEIL
CCCCCCCCCCCHHHH		31.7030988701
1171MethylationLRPGSGGRGRFRGGD
ECCCCCCCCCCCCCC		36.3216189061
1238PhosphorylationGKTSVTVYPGDAFCL
CEEEEEECCCCEEEE		7.6723140645
1247PhosphorylationGDAFCLHTPGGGGYG
CCEEEEECCCCCCCC		15.6423140645
1253PhosphorylationHTPGGGGYGDPEDPA
ECCCCCCCCCCCCCC		22.9423984901
1265PhosphorylationDPAPPPGSPPLYPAF
CCCCCCCCCCCCCCC		29.1726643407
1269PhosphorylationPPGSPPLYPAFPERG
CCCCCCCCCCCCCCC		9.7826643407
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of OPLA_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of OPLA_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of OPLA_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of OPLA_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of OPLA_MOUSE

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Related Literatures of Post-Translational Modification

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