PAPD5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAPD5_MOUSE
• UniProt AC: Q68ED3
• Protein Name: Non-canonical poly(A) RNA polymerase PAPD5
• Gene Name: Papd5
• Organism: Mus musculus (Mouse).
• Sequence Length: 633
• Subcellular Localization: Nucleus . Nucleus, nucleolus . Cytoplasm . Predominantly expressed in the cytoplasm.
• Protein Description: Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion (By similarity)..
• Protein Sequence: MFRSGERPLGGLAVPAEQRDFLPLETTNNNNNHHQPAAWARRASAGPSASPVPSAPSSPRPAAALPASESTDPASGSSNKRKRDNKASTYGLNYSLLQPSGGRAAGGGRADGGGGVYSGTPWKRRNYNQGVVGLHEEISDFYEYMSPRPEEEKMRMEVVSRIESVIKELWPSADVQIFGSFKTGLYLPTSDIDLVVFGKWENLPLWTLEEALRKHKVADEDSVKVLDKATVPIIKLTDSFTEVKVDISFNVQNGVRAADLIKDFTKKYPVLPYLVLVLKQFLLQRDLNEVFTGGIGSYSLFLMAVSFLQLHPREDACIPNTNYGVLLIEFFELYGRHFNYLKTGIRIKDGGSYVAKDEVQKNMLDGYRPSMLYIEDPLQPGNDVGRSSYGAMQVKQAFDYAYVVLSHAVSPIAKYYPNNETESILGRIIRVTDEVATYRDWISKQWGLQNRPEPSCNGNGVTLIVDTQQLDKCNNNLSEEKEALGKCRSNASEPLSKHSSNSSSGPVSSSSATQSSSSDVDSDATPCKTPKQLLCRPPTVTRVGSQDVSLEVSQAVGKMQSTQTTNTPNNANKSQHGSARLFRSSSKGFQGTAQTSHGALMTSKQHQGKSNTQYYHGKKRRHKRDAPLSELCR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	AAWARRASAGPSASP CHHHHHHCCCCCCCC	31.76	22942356
48	Phosphorylation	RRASAGPSASPVPSA HHHCCCCCCCCCCCC	40.22	26643407
50	Phosphorylation	ASAGPSASPVPSAPS HCCCCCCCCCCCCCC	30.67	21082442
54	Phosphorylation	PSASPVPSAPSSPRP CCCCCCCCCCCCCCC	53.71	20469934
57	Phosphorylation	SPVPSAPSSPRPAAA CCCCCCCCCCCCCCC	53.33	21082442
58	Phosphorylation	PVPSAPSSPRPAAAL CCCCCCCCCCCCCCC	24.70	21082442
68	Phosphorylation	PAAALPASESTDPAS CCCCCCCCCCCCCCC	30.09	26643407
70	Phosphorylation	AALPASESTDPASGS CCCCCCCCCCCCCCC	35.30	26643407
71	Phosphorylation	ALPASESTDPASGSS CCCCCCCCCCCCCCC	41.78	25777480
75	Phosphorylation	SESTDPASGSSNKRK CCCCCCCCCCCCCCC	44.59	26643407
77	Phosphorylation	STDPASGSSNKRKRD CCCCCCCCCCCCCCC	28.39	25777480
78	Phosphorylation	TDPASGSSNKRKRDN CCCCCCCCCCCCCCC	50.31	25777480
127	Phosphorylation	TPWKRRNYNQGVVGL CCCCCCCCCCCCCCC	13.67	27357545
356	Ubiquitination	DGGSYVAKDEVQKNM CCCCEECCHHHHHCC	44.36	-
508	Phosphorylation	NSSSGPVSSSSATQS CCCCCCCCCCCCCCC	27.86	29472430
509	Phosphorylation	SSSGPVSSSSATQSS CCCCCCCCCCCCCCC	28.66	29472430
510	Phosphorylation	SSGPVSSSSATQSSS CCCCCCCCCCCCCCC	19.24	29472430
511	Phosphorylation	SGPVSSSSATQSSSS CCCCCCCCCCCCCCC	36.96	29472430
513	Phosphorylation	PVSSSSATQSSSSDV CCCCCCCCCCCCCCC	30.82	23684622
515	Phosphorylation	SSSSATQSSSSDVDS CCCCCCCCCCCCCCC	28.03	29472430
516	Phosphorylation	SSSATQSSSSDVDSD CCCCCCCCCCCCCCC	24.84	29472430
517	Phosphorylation	SSATQSSSSDVDSDA CCCCCCCCCCCCCCC	35.49	29472430
518	Phosphorylation	SATQSSSSDVDSDAT CCCCCCCCCCCCCCC	43.53	23608596
522	Phosphorylation	SSSSDVDSDATPCKT CCCCCCCCCCCCCCC	29.06	29472430
525	Phosphorylation	SDVDSDATPCKTPKQ CCCCCCCCCCCCHHH	33.92	29472430
545	Phosphorylation	PTVTRVGSQDVSLEV CEEEEECCCCEEEHH	21.98	25521595
549	Phosphorylation	RVGSQDVSLEVSQAV EECCCCEEEHHHHHH	27.40	28833060
567	Phosphorylation	QSTQTTNTPNNANKS CCCCCCCCCCCCCCC	25.87	25263469

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PAPD5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAPD5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAPD5_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PAPD5_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.