IGS10_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IGS10_MOUSE
• UniProt AC: Q3V1M1
• Protein Name: Immunoglobulin superfamily member 10
• Gene Name: Igsf10
• Organism: Mus musculus (Mouse).
• Sequence Length: 2594
• Subcellular Localization: Secreted .
• Protein Description: Involved in the control of early migration of neurons expressing gonadotropin-releasing hormone (GNRH neurons). [PubMed: 27137492 May be involved in the maintenance of osteochondroprogenitor cells pool (By similarity]
• Protein Sequence: MQKRGREVSCLLISLTAICLVVTPGSRVCPRRCACYVPTEVHCTFRYLTSIPDGIPANVERVNLGYNSLTRLTENDFSGLSRLELLMLHSNGIHRVSDKTFSGLQSLQVLKMSYNKVQIIEKDTLYGLRSLTRLHLDHNNIEFINPEAFYGLTLLRLVHLEGNRLTKLHPDTFVSLSYLQIFKTSFIKYLYLSDNFLTSLPKEMVSSMPNLESLYLHGNPWTCDCHLKWLSEWMQGNPDIIKCKKERIPSSPQQCPLCMNPRISKGRSIAMVPSGSFLCTKPTIDPSLKSKSLGIQEDNGSASVSPQDFIEPFGSLSLNMTDLSGNKANVICSIQKPSRTLPIAFTEENDYIMLNMSFSTNLVCSVNYNHIQPVWQLLALYSDSPLILERKPQHTETPLLSPKYQQVALRPEDTFTNIEADFKADPFWFQQEKISLQLNRTATTLSTLQIQFSTDAQITLPKAEMRPVKRKWTMILMMNNTRLEHTVLVGGTIALDCPGKGDPSPHLEWVLADGSKVRAPYVSEDGRILIDKKGKLELQMADTFDAGLYHCISTNDADADILTYRITVVEPYVENKHENGALHTVIMGEILDLPCLSTGIPDASISWILPRNTVFSQSSRDMQILNNGTLRILQATPKDQGHYRCVAANPSGADFSSFQVSVQMKGQRTIEHDRDIDGSGLEEPKPSVLLKQPPSLKLPASSLTGTEAGKQVSGIHKKNKHRDLTHRRRGDSTLRRFREHRRQLPLSARRIDPQHWAALLEKAKKNSVLRKQENTTVKPTPLAIPLVELAGEEKDASGLTPPDEEFTVLKTKAFGVPERSPTADSRPVNHGFVTSSASGTEVSSTVNPQTLLPTHLPDFKLFNVVDSAAVSKSMNRPVTSKIEDTTHQNPIIIFPSVAEIQDSAQVGRTSSQSAHPATGGAMATYGYTTMLSSFTNKANTVLQSANPTESYGPQIPLTEVSRVSSNNSLAHTTKDPGFSKRPSDSHTTAPSLFQTPRNNSTGNVGRERTIWSRGRAISPYRTPVLRRHRHRIVRPALKGPANRNISQVSATEPPGMCRTCSSTERLTMATAALSVTGSSHTTLPKANNVGIISEESTTVVKKPSLLLKNKQDVDIETITTTINYFRSESTHMTPTEASMISAPTSISLGKTPIDTSGHLSMPRTIQAGTDLVVTPPLSSPLSQPSIPTKATSTKLSRRKIPWHPIFANNHNKEGMLKNLHQFGLQKNTATKPPEKAPLLPTDHGSSSPSTTLLASLTPAQSATMAATRRNGTEVQGARSLSAGKEQPFINSFLVLPSTTRKRSSTLSFLSVETPTVTTPPVIASAIISETQEVRSKKAKDQTKGSLKNRKGPTITPRQISGYSTYSVPTTTDTPLAFSHSPGKVTGRTVSTAAPHSAASLLGITELPQKCTHTSGNITASETTLLSKSQESTAMKRASATPPLLSSGAPRMPTPSPPPFTKVVVTDSEVPAVFKMMSNRMVTIYESSRHDIDLQQPSAEASPNPEILTGSTDFPLSSLLTSTPMPAPRVDKPQDSQWKPSPWPENKFQLRSYSETIEKGKRPEISLSPHLSFPEASTHALHWNAQRHAEKSVFDKKPAQNPTSKHLPYDSLPKTILKKPRIIGGKAASFTVPTNSDVLLPCEAVGDPKPTIHWTRVSSGREISRGIQKTRFHVLPNGTLSIQRVSIQDRGQYLCAASNPLGVDHLHVTLSVVSYPARILESHVKEITAHSGSTVKLKCRVEGMPRPTISWILANQTVVSETPEGSRKVWVTPDGTLIIHNLSLYDRGFYKCVANNPSGQDSLLVKIQVITAPPVIIEQKRQAIVGVLGESLKLPCTAKGTPQPSVHWVLYDGTELKPLQLTHSRFFLYPNGTLYIRNIVSSVRGTYECIATSSSGSERRVVILRVEEQETVPRIETASQKWTEVNLGEKLLLNCSATGDPKPTIIWKLPSKVVIDQWHRMGSRIHVYPNGSLVIGSVTEKDGGDYLCVARNKMGDDLVLMHVRLRLTPAKIEHKQHFKKQVLHGKDFQVDCKASGSPVPEVSWSLPDGTVVNNVAQADDSGYRTKRYTLFHNGTLYFNKVGMAEEGDYICSAQNTLGKDEMKVHLTVLTAIPRIRQNYRSNVRIKAGDTAVLDCEVTGEPKPNVFWLLPSNNVISFSNDRFIFHANGTLSINKVKPLDSGKYVCVAQNPSGDDTKTYKLDIVSRPPLINGLYANKTVIKATAIQHSKKHLDCRADGVPPPQITWIMPDNIFLTAPYYGGRITVHQNGTLEIRNIRLSDSADFTCVVRSEGGESVLVVQLKVLEMLRRPTFRNPFNEKVVAQVGKPVAMNCSVDGNPTPEIIWILPDGTQFANGPQNSPYLMASNGSLIVYKATRNKSGKYRCTARNKVGYIEKLILLEIGQKPVILTYEPGMIKSAGGESLSLHCVSDGIPKPNVKWTTPGGLVIDRPQVGGKYILHENGTLVIKETTAHDRGNYICKAQNSVGQAVISVPVTIVAYPPRIINYLPRSMLRRTGEAMQLHCVALGVPKPQITWETPGYSLLSTATERRPHRSEMLPLQGTLVIQNLRASDSGVYKCRAQNVLGADYATTYIQVL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
439	N-linked_Glycosylation	EKISLQLNRTATTLS HHEEEEECCCCCCCC	26.71	-
627	N-linked_Glycosylation	RDMQILNNGTLRILQ HCEEEECCCCEEEEE	41.19	-
713	Phosphorylation	TEAGKQVSGIHKKNK CHHHHCCCCCCCCCC	29.54	28059163
820	Phosphorylation	AFGVPERSPTADSRP ECCCCCCCCCCCCCC	25.58	21149613
822	Phosphorylation	GVPERSPTADSRPVN CCCCCCCCCCCCCCC	44.32	21149613
825	Phosphorylation	ERSPTADSRPVNHGF CCCCCCCCCCCCCCC	35.70	21149613
1044	N-linked_Glycosylation	LKGPANRNISQVSAT HCCCCCCCCCCCCCC	37.76	-
1133	Phosphorylation	RSESTHMTPTEASMI HCCCCCCCCCCHHHC	21.32	24759943
1135	Phosphorylation	ESTHMTPTEASMISA CCCCCCCCCHHHCCC	34.71	24759943
1160	Phosphorylation	IDTSGHLSMPRTIQA CCCCCCCCCCCEEEC	22.52	24759943
1307	Phosphorylation	RKRSSTLSFLSVETP CCCCCCCEEEEECCC	24.99	-
1310	Phosphorylation	SSTLSFLSVETPTVT CCCCEEEEECCCCCC	18.85	-
1328	Phosphorylation	VIASAIISETQEVRS HHHHHHHHCHHHHHH	28.60	-
1591	Phosphorylation	AQRHAEKSVFDKKPA HHHHHHHCCCCCCCC	21.37	28066266
1669	Phosphorylation	ISRGIQKTRFHVLPN ECCCCEECCEEECCC	23.38	22871156
1676	N-linked_Glycosylation	TRFHVLPNGTLSIQR CCEEECCCCCEEEEE	52.50	-
1680	Phosphorylation	VLPNGTLSIQRVSIQ ECCCCCEEEEEEEEC	19.26	22871156
1724	Acetylation	RILESHVKEITAHSG HHHHHHHEEEECCCC	37.67	22826441
1780	N-linked_Glycosylation	DGTLIIHNLSLYDRG CCCEEEECCCCCCCC	22.40	-
1810	Phosphorylation	LVKIQVITAPPVIIE EEEEEEEECCCEEEH	33.97	-
1830	Phosphorylation	IVGVLGESLKLPCTA HHHHCCCCCCCCCCC	29.07	-
1870	N-linked_Glycosylation	SRFFLYPNGTLYIRN CEEEEECCCEEEEEC	42.39	-
1933	N-linked_Glycosylation	LGEKLLLNCSATGDP CCCCEEEECCCCCCC	20.05	-
2072	N-linked_Glycosylation	KRYTLFHNGTLYFNK EEEEEEECCEEEECC	37.50	-
2364	N-linked_Glycosylation	SPYLMASNGSLIVYK CCEEEECCCCEEEEE	34.24	-
2482	Phosphorylation	YICKAQNSVGQAVIS EEEEECCCCCCEEEE	18.62	29899451
2493	Phosphorylation	AVISVPVTIVAYPPR EEEEECEEEEECCHH	12.03	29899451
2574	Phosphorylation	RASDSGVYKCRAQNV CCCCCCEEEEHHHCC	14.11	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IGS10_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IGS10_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IGS10_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of IGS10_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.