MA2C1_MOUSE - dbPTM
MA2C1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MA2C1_MOUSE
UniProt AC Q91W89
Protein Name Alpha-mannosidase 2C1
Gene Name Man2c1 {ECO:0000303|PubMed:16904268}
Organism Mus musculus (Mouse).
Sequence Length 1039
Subcellular Localization Cytoplasm .
Protein Description Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues from glycoproteins. Involved in the degradation of free oligosaccharides in the cytoplasm..
Protein Sequence MAAAPFLKHWRTTFERVEKFVSPIYFTDCNLRGRLFGDSCSVTLSSFLTPERLPYEKAVQQNFSPAQVGDSFGPTWWTCWFRVELVIPEVWVGQEVHLCWESDGESLVWRDGEPVQGLTKEGEKTSYVLSERLRASDPRSLTLYVEVACNGLLGAGKGSMIAAPDPEKMFQLSQAKLAVFHRDVHSLLVDLELLLGVAKGLGEDSQRSFQALHTANQMVNICDPAQPETYPAAKALASKFFGQHGGESQHTIHAMGHCHIDTAWLWPFKETVRKCARSWSTAVTLMEQNTDFIFACSQAQQLEWVKSQYPGLHARLQEFACRGQFVPVGGTWVEMDGNLPSGEAMVRQFLQGQNFFLQEFGKMCSEFWLPDTFGYSAQLPQIMQGCGIKRFLTQKLSWNLVNSFPHHTFFWEGLDGSRVLVHFPPGDSYGMQGSVEEVLKTVTNNRDKGRTNHSGFLFGFGDGGGGPTQTMLDRLKRLSNTDGLPRVQLSSPGQLFTALERDSGQLCTWVGELFLELHNGTYTTHAQLKKGNRECEQILHDVEVLSSLALARSAQFLYPAAQLQHLWRLLLLNQFHDVVTGSCIQLVAEDAMNYYEDIRSHGNPLLSAAAAALCAGEPGPKGLLIINTLPWKRTEVLALPKPCGAHSLALVTVPSIGYAPAPTPTSLQPLLPQQPVFVMQETDGSVTLDNGIIRVRLDPTGCLTSLVLVASGREAIAEGALGNQFVLFDDVPLYWDAWDVMDYHLETRKPVLGQAGTLAVGTEGGLRGSAWFLLQISPNSRLSQEVVLDVGCPYVRFHTEVHWHEAHKFLKVEFPARIRSPQATYEIQFGHLQRPTHNNTSWDWARYEVWAHRWIDLSECDFGLALLNNCKYGASVRGNVLSLSLLRAPKAPDATADMGRHEFTYALMPHKGSFQEAGVIHAAYNLNFPLLALPAPGPAPDTTWSAFSVSSPAVVLETIKQAERCHQHRTLVLRLYEAHGSHVDCWLHTSLPVQEATLCDLLEQRDPTGHLSLQDNRLKLTFSPFQVRSLLLVLQSPPN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8UbiquitinationMAAAPFLKHWRTTFE
CCCCHHHHHHHHHHH		41.3122790023
8UbiquitinationMAAAPFLKHWRTTFE
CCCCHHHHHHHHHHH		41.31-
12PhosphorylationPFLKHWRTTFERVEK
HHHHHHHHHHHHHHH		30.5528576409
13PhosphorylationFLKHWRTTFERVEKF
HHHHHHHHHHHHHHH		18.2228576409
125PhosphorylationLTKEGEKTSYVLSER
CCCCCCCCHHHEEHH		22.4626643407
126PhosphorylationTKEGEKTSYVLSERL
CCCCCCCHHHEEHHH		25.0626643407
127PhosphorylationKEGEKTSYVLSERLR
CCCCCCHHHEEHHHH		15.6126643407
130PhosphorylationEKTSYVLSERLRASD
CCCHHHEEHHHHCCC		15.6126643407
331PhosphorylationQFVPVGGTWVEMDGN
CEECCCCEEEEECCC		22.0227180971
479PhosphorylationLDRLKRLSNTDGLPR
HHHHHHHCCCCCCCC		41.5426160508
481PhosphorylationRLKRLSNTDGLPRVQ
HHHHHCCCCCCCCEE		28.2426160508
749UbiquitinationDYHLETRKPVLGQAG
HHHHHCCCCCCCCCE		47.0722790023
749UbiquitinationDYHLETRKPVLGQAG
HHHHHCCCCCCCCCE		47.07-
777UbiquitinationAWFLLQISPNSRLSQ
EEEEEEECCCCCCCC		12.6927667366
808UbiquitinationVHWHEAHKFLKVEFP
EEHHHHHCCEEEEEC		60.4827667366
811UbiquitinationHEAHKFLKVEFPARI
HHHHCCEEEEECCCC		42.7422790023
811UbiquitinationHEAHKFLKVEFPARI
HHHHCCEEEEECCCC		42.74-
879UbiquitinationYGASVRGNVLSLSLL
CCCCCCCCEEEHHHE		22.4627667366
910UbiquitinationFTYALMPHKGSFQEA
EEEEECCCCCCHHHH		32.8927667366
914UbiquitinationLMPHKGSFQEAGVIH
ECCCCCCHHHHCCEE		11.8127667366
932UbiquitinationNLNFPLLALPAPGPA
ECCCCEEECCCCCCC		21.1227667366
945UbiquitinationPAPDTTWSAFSVSSP
CCCCCCCCCEECCCC		19.8327667366
986UbiquitinationHGSHVDCWLHTSLPV
HCCCCCEEEECCCCC		6.1627667366
1012PhosphorylationRDPTGHLSLQDNRLK
CCCCCCCEECCCCEE		20.5028464351
1019UbiquitinationSLQDNRLKLTFSPFQ
EECCCCEEEEECHHH		42.0927667366
1019UbiquitinationSLQDNRLKLTFSPFQ
EECCCCEEEEECHHH		42.0922790023
1036PhosphorylationSLLLVLQSPPN----
HHHHHHCCCCC----		37.8628066266
1051Ubiquitination-------------------
-------------------		27667366
1056Ubiquitination------------------------
------------------------		27667366
1076Ubiquitination--------------------------------------------
--------------------------------------------		27667366
1082Ubiquitination--------------------------------------------------
--------------------------------------------------		27667366
1086Ubiquitination------------------------------------------------------
------------------------------------------------------		27667366
1117Ubiquitination-------------------------------------------------------------------------------------
-------------------------------------------------------------------------------------		27667366
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MA2C1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MA2C1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MA2C1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MA2C1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MA2C1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-479 AND THR-481, ANDMASS SPECTROMETRY.

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