ECI1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ECI1_MOUSE
• UniProt AC: P42125
• Protein Name: Enoyl-CoA delta isomerase 1, mitochondrial
• Gene Name: Eci1
• Organism: Mus musculus (Mouse).
• Sequence Length: 289
• Subcellular Localization: Mitochondrion matrix.
• Protein Description: Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species..
• Protein Sequence: MALAAARRLLLHAGSRLGRREAVDGARRFANKRVLVETEGPAGVAVMKLRNPPVNSLSLECLTEFTISLEKLENDKSIRGVILTSECPGIFSAGLDLLEMYGRNPAHYAEYWKNVQELWLRLYTSNMILVSAINGASPAGGCLLALCCDYRVMADNPKYTIGLNESLLGIVAPFWFKDMYVNTIGHREAERALQLGTLFSPAEALKVGVVDEVVPEDQVHSKARSVMTKWLAIPDHSRQLTKNMMRKATADNLIKQREADIQNFTSFISKDSIQKSLHMYLEKLKQKKG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Acetylation	PAGVAVMKLRNPPVN CCCEEEEECCCCCCC	37.38	23576753
48	Succinylation	PAGVAVMKLRNPPVN CCCEEEEECCCCCCC	37.38	23806337
48	Succinylation	PAGVAVMKLRNPPVN CCCEEEEECCCCCCC	37.38	-
61	S-nitrosocysteine	VNSLSLECLTEFTIS CCCEEHHHHHEEEEE	7.46	-
61	Glutathionylation	VNSLSLECLTEFTIS CCCEEHHHHHEEEEE	7.46	24333276
71	Acetylation	EFTISLEKLENDKSI EEEEEHHHHCCCCCC	67.41	23806337
71	Succinylation	EFTISLEKLENDKSI EEEEEHHHHCCCCCC	67.41	23806337
71	Succinylation	EFTISLEKLENDKSI EEEEEHHHHCCCCCC	67.41	-
76	Acetylation	LEKLENDKSIRGVIL HHHHCCCCCCCEEEE	60.40	23576753
76	Succinylation	LEKLENDKSIRGVIL HHHHCCCCCCCEEEE	60.40	23806337
76	Glutarylation	LEKLENDKSIRGVIL HHHHCCCCCCCEEEE	60.40	24703693
76	Malonylation	LEKLENDKSIRGVIL HHHHCCCCCCCEEEE	60.40	26320211
113	Acetylation	AHYAEYWKNVQELWL HHHHHHHHHHHHHHH	46.46	23864654
158	Acetylation	RVMADNPKYTIGLNE EECCCCCCEEEECCH	62.37	23806337
158	Succinylation	RVMADNPKYTIGLNE EECCCCCCEEEECCH	62.37	23806337
200	Phosphorylation	LQLGTLFSPAEALKV HHHCCCCCHHHHHHC	26.72	27180971
206	Succinylation	FSPAEALKVGVVDEV CCHHHHHHCCCCCCC	43.95	26388266
206	Acetylation	FSPAEALKVGVVDEV CCHHHHHHCCCCCCC	43.95	23576753
221	Phosphorylation	VPEDQVHSKARSVMT CCHHHHHHHHHHHHH	29.20	27742792
222	Succinylation	PEDQVHSKARSVMTK CHHHHHHHHHHHHHH	32.70	23806337
222	Succinylation	PEDQVHSKARSVMTK CHHHHHHHHHHHHHH	32.70	-
222	Acetylation	PEDQVHSKARSVMTK CHHHHHHHHHHHHHH	32.70	23576753
222	Malonylation	PEDQVHSKARSVMTK CHHHHHHHHHHHHHH	32.70	26320211
222	Glutarylation	PEDQVHSKARSVMTK CHHHHHHHHHHHHHH	32.70	24703693
229	Succinylation	KARSVMTKWLAIPDH HHHHHHHHHHHCCHH	23.32	23806337
229	Succinylation	KARSVMTKWLAIPDH HHHHHHHHHHHCCHH	23.32	-
229	Acetylation	KARSVMTKWLAIPDH HHHHHHHHHHHCCHH	23.32	23576753
229	Malonylation	KARSVMTKWLAIPDH HHHHHHHHHHHCCHH	23.32	26320211
229	Glutarylation	KARSVMTKWLAIPDH HHHHHHHHHHHCCHH	23.32	24703693
247	Malonylation	LTKNMMRKATADNLI HHHHHHHHHHHHHHH	31.99	26320211
247	Glutarylation	LTKNMMRKATADNLI HHHHHHHHHHHHHHH	31.99	24703693
249	Phosphorylation	KNMMRKATADNLIKQ HHHHHHHHHHHHHHH	37.26	22817900
255	Succinylation	ATADNLIKQREADIQ HHHHHHHHHHHHHHH	46.60	-
255	Acetylation	ATADNLIKQREADIQ HHHHHHHHHHHHHHH	46.60	23576753
255	Succinylation	ATADNLIKQREADIQ HHHHHHHHHHHHHHH	46.60	23806337
255	Glutarylation	ATADNLIKQREADIQ HHHHHHHHHHHHHHH	46.60	24703693
255	Malonylation	ATADNLIKQREADIQ HHHHHHHHHHHHHHH	46.60	26320211
265	Phosphorylation	EADIQNFTSFISKDS HHHHHHHHHHHCHHH	30.22	29899451
266	Phosphorylation	ADIQNFTSFISKDSI HHHHHHHHHHCHHHH	19.22	22817900
269	Phosphorylation	QNFTSFISKDSIQKS HHHHHHHCHHHHHHH	28.53	19060867
270	Ubiquitination	NFTSFISKDSIQKSL HHHHHHCHHHHHHHH	51.16	-
270	Succinylation	NFTSFISKDSIQKSL HHHHHHCHHHHHHHH	51.16	23806337
270	Ubiquitination	NFTSFISKDSIQKSL HHHHHHCHHHHHHHH	51.16	22790023
270	Succinylation	NFTSFISKDSIQKSL HHHHHHCHHHHHHHH	51.16	-
270	Acetylation	NFTSFISKDSIQKSL HHHHHHCHHHHHHHH	51.16	23576753
270	Glutarylation	NFTSFISKDSIQKSL HHHHHHCHHHHHHHH	51.16	24703693
272	Phosphorylation	TSFISKDSIQKSLHM HHHHCHHHHHHHHHH	30.56	22817900
275	Succinylation	ISKDSIQKSLHMYLE HCHHHHHHHHHHHHH	54.00	23806337
275	Succinylation	ISKDSIQKSLHMYLE HCHHHHHHHHHHHHH	54.00	-
275	Acetylation	ISKDSIQKSLHMYLE HCHHHHHHHHHHHHH	54.00	23864654
275	Glutarylation	ISKDSIQKSLHMYLE HCHHHHHHHHHHHHH	54.00	24703693
283	Succinylation	SLHMYLEKLKQKKG- HHHHHHHHHHHHCC-	59.39	-
283	Succinylation	SLHMYLEKLKQKKG- HHHHHHHHHHHHCC-	59.39	23806337
283	Acetylation	SLHMYLEKLKQKKG- HHHHHHHHHHHHCC-	59.39	23576753
283	Glutarylation	SLHMYLEKLKQKKG- HHHHHHHHHHHHCC-	59.39	24703693

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ECI1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ECI1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ECI1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ECI1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.