ANPRB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANPRB_MOUSE
• UniProt AC: Q6VVW5
• Protein Name: Atrial natriuretic peptide receptor 2
• Gene Name: Npr2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1047
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth..
• Protein Sequence: MALPSLLLVVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRALPVDLRFVSSELDGACSEYLAPLRAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLLTAGAVASGFAAKNEHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWWTGRPIPWVKGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGVTFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSDRYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGEQKGPPGLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	N-linked_Glycosylation	VRPPGARNLTLAVVL CCCCCCCCEEEEEEE	36.52	-
35	N-linked_Glycosylation	AVVLPEHNLSYAWAW EEEECCCCCCEECCC	29.08	-
138	Phosphorylation	AKNEHYRTLVRTGPS HCCHHHHHEECCCCC	23.57	22871156
161	N-linked_Glycosylation	VTLHGHFNWTARAAL EEECCCCCHHHEEHH	29.52	-
195	N-linked_Glycosylation	FEALQGSNLSVQHQV HHHHCCCCCEEEEEE	43.06	-
244	N-linked_Glycosylation	LLQAQRENLTNGDYV HHHHHHHCCCCCCEE	55.12	-
277	N-linked_Glycosylation	TGRPWQDNRTQEQAQ CCCCCCCCCHHHHHH	33.52	-
349	N-linked_Glycosylation	LLYAQVLNETIQEGG HHHHHHHHHHHHCCC	45.57	-
513	Phosphorylation	RYHKGAGSRLTLSLR CCCCCCCCEEEEEEC	24.47	-
516	Phosphorylation	KGAGSRLTLSLRGSS CCCCCEEEEEECCCC	17.12	26370283
518	Phosphorylation	AGSRLTLSLRGSSYG CCCEEEEEECCCCCC	15.70	26370283
522	Phosphorylation	LTLSLRGSSYGSLMT EEEEECCCCCCCCEE	17.60	29472430
523	Phosphorylation	TLSLRGSSYGSLMTA EEEECCCCCCCCEEC	36.02	26824392
526	Phosphorylation	LRGSSYGSLMTAHGK ECCCCCCCCEECCEE	13.51	22817900
529	Phosphorylation	SSYGSLMTAHGKYQI CCCCCCEECCEEEEE	22.31	-
534	Phosphorylation	LMTAHGKYQIFANTG CEECCEEEEEEECCC	16.07	29514104
640	Phosphorylation	FLHNSIISSHGSLKS HHCHHHHHCCCCCCC	18.02	21183079
641	Phosphorylation	LHNSIISSHGSLKSS HCHHHHHCCCCCCCC	22.81	21183079
647	Phosphorylation	SSHGSLKSSNCVVDS HCCCCCCCCCEEEEC	31.88	21183079
687	Phosphorylation	LYAKKLWTAPELLSG HHHHHCCCCHHHHCC	42.65	25367039
734	Ubiquitination	EGLDLSPKEIVQKVR CCCCCCHHHHHHHHH	57.61	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANPRB_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANPRB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANPRB_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANPRB_MOUSE	Npr2	physical	14514678

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.