AT2A1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AT2A1_MOUSE
• UniProt AC: Q8R429
• Protein Name: Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
• Gene Name: Atp2a1
• Organism: Mus musculus (Mouse).
• Sequence Length: 994
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Sarcoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. [PubMed: 21697544]
• Protein Sequence: MEAAHSKSTEECLSYFGVSETTGLTPDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRILLLAACISFVLAWFEEGEETVTAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDVCSLNEFSITGSTYAPEGEVLKNDKPVRAGQYDGLVELATICALCNDSSLDFNETKGVYEKVGEATETALTTLVEKMNVFNTEVRSLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMSVIKEWGTGRDTLRCLALATRDTPPKREEMVLDDSAKFMEYEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFSENEEVTDRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATVGAAAWWFLYAEDGPHVSYHQLTHFMQCTEHNPEFDGLDCEVFEAPEPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDFTQWLMVLKISLPVIGLDELLKFIARNYLEG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Ubiquitination	-MEAAHSKSTEECLS -CCCCCCCCHHHHHH	52.08	22790023
15	Phosphorylation	STEECLSYFGVSETT CHHHHHHHHCCCCCC	7.45	28464351
19	Phosphorylation	CLSYFGVSETTGLTP HHHHHCCCCCCCCCH	29.60	28464351
21	Phosphorylation	SYFGVSETTGLTPDQ HHHCCCCCCCCCHHH	20.75	28464351
30	Ubiquitination	GLTPDQVKRHLEKYG CCCHHHHHHHHHHHC	28.59	22790023
35	Ubiquitination	QVKRHLEKYGPNELP HHHHHHHHHCCCCCC	62.96	22790023
36	Phosphorylation	VKRHLEKYGPNELPA HHHHHHHHCCCCCCH	28.56	28464351
120	Ubiquitination	ENAIEALKEYEPEMG HHHHHHHHHHCHHCC	66.36	22790023
122	Phosphorylation	AIEALKEYEPEMGKV HHHHHHHHCHHCCCE	34.89	28464351
128	Ubiquitination	EYEPEMGKVYRADRK HHCHHCCCEEECCHH	34.48	22790023
131	Dimethylation	PEMGKVYRADRKSVQ HHCCCEEECCHHHHH	32.76	-
136	Phosphorylation	VYRADRKSVQRIKAR EEECCHHHHHHHHHC	25.11	22324799
139	Dimethylation	ADRKSVQRIKARDIV CCHHHHHHHHHCCCC	30.16	-
167	Phosphorylation	PADIRILSIKSTTLR CCCEEEEEEECCEEE	26.12	24719451
169	Ubiquitination	DIRILSIKSTTLRVD CEEEEEEECCEEEEE	38.07	22790023
181	Phosphorylation	RVDQSILTGESVSVI EEECHHHCCCCEEEE	36.91	27742792
184	Phosphorylation	QSILTGESVSVIKHT CHHHCCCCEEEEECC	22.49	23737553
186	Phosphorylation	ILTGESVSVIKHTDP HHCCCCEEEEECCCC	27.66	23737553
189	Ubiquitination	GESVSVIKHTDPVPD CCCEEEEECCCCCCC	37.99	22790023
191	Phosphorylation	SVSVIKHTDPVPDPR CEEEEECCCCCCCCC	36.68	28464351
205	Ubiquitination	RAVNQDKKNMLFSGT CCCCCCCCCCCCCCC	56.74	22790023
210	Phosphorylation	DKKNMLFSGTNIAAG CCCCCCCCCCCCCCC	40.52	27742792
212	Phosphorylation	KNMLFSGTNIAAGKA CCCCCCCCCCCCCCC	23.42	27742792
226	Phosphorylation	AVGIVATTGVSTEIG CCEEEEECCCCHHHH	26.33	28464351
230	Phosphorylation	VATTGVSTEIGKIRD EEECCCCHHHHHHHH	29.26	28464351
234	Ubiquitination	GVSTEIGKIRDQMAA CCCHHHHHHHHHHCC	39.98	22790023
242	Phosphorylation	IRDQMAATEQDKTPL HHHHHCCCCCCCCHH	25.33	28464351
246	Ubiquitination	MAATEQDKTPLQQKL HCCCCCCCCHHHHHH	52.30	22790023
294	Nitration	SWFRGAIYYFKIAVA CCHHHHHHHHHHHHH	11.43	-
295	Nitration	WFRGAIYYFKIAVAL CHHHHHHHHHHHHHH	7.71	-
328	Ubiquitination	LGTRRMAKKNAIVRS HCCHHHHHHCHHHHC	36.90	22790023
335	Phosphorylation	KKNAIVRSLPSVETL HHCHHHHCCCCCCCC	33.46	28464351
338	Phosphorylation	AIVRSLPSVETLGCT HHHHCCCCCCCCCCC	37.57	22210690
341	Phosphorylation	RSLPSVETLGCTSVI HCCCCCCCCCCCEEE	26.71	28464351
344	Glutathionylation	PSVETLGCTSVICSD CCCCCCCCCEEEEEC	2.63	24333276
345	Phosphorylation	SVETLGCTSVICSDK CCCCCCCCEEEEECC	24.99	28464351
346	Phosphorylation	VETLGCTSVICSDKT CCCCCCCEEEEECCC	17.35	28542873
349	Glutathionylation	LGCTSVICSDKTGTL CCCCEEEEECCCCCC	3.95	24333276
353	Phosphorylation	SVICSDKTGTLTTNQ EEEEECCCCCCCCCC	40.15	28542873
355	Phosphorylation	ICSDKTGTLTTNQMS EEECCCCCCCCCCCC	26.60	28464351
357	Phosphorylation	SDKTGTLTTNQMSVC ECCCCCCCCCCCCEE	24.44	28542873
358	Phosphorylation	DKTGTLTTNQMSVCK CCCCCCCCCCCCEEE	26.94	28464351
362	Phosphorylation	TLTTNQMSVCKMFII CCCCCCCCEEEEEEE	18.01	28464351
378	Phosphorylation	KVDGDVCSLNEFSIT ECCCCEEECEEEEEC	33.79	28464351
383	Phosphorylation	VCSLNEFSITGSTYA EEECEEEEECCCCCC	17.05	22210690
385	Phosphorylation	SLNEFSITGSTYAPE ECEEEEECCCCCCCC	24.71	22210690
387	Phosphorylation	NEFSITGSTYAPEGE EEEEECCCCCCCCCC	15.03	22210690
388	Phosphorylation	EFSITGSTYAPEGEV EEEECCCCCCCCCCC	25.66	22210690
415	Phosphorylation	DGLVELATICALCND CHHHHHHHHHHHHCC	29.25	21183079
436	Ubiquitination	ETKGVYEKVGEATET CCCCHHHHHHHHHHH	37.54	22790023
441	Phosphorylation	YEKVGEATETALTTL HHHHHHHHHHHHHHH	29.57	28542873
443	Phosphorylation	KVGEATETALTTLVE HHHHHHHHHHHHHHH	23.70	28464351
457	Phosphorylation	EKMNVFNTEVRSLSK HHHCCCCHHHHHCHH	25.13	22210690
461	Phosphorylation	VFNTEVRSLSKVERA CCCHHHHHCHHHHHH	42.02	22210690
463	Phosphorylation	NTEVRSLSKVERANA CHHHHHCHHHHHHHH	35.58	22210690
464	Ubiquitination	TEVRSLSKVERANAC HHHHHCHHHHHHHHH	54.10	22790023
473	Phosphorylation	ERANACNSVIRQLMK HHHHHHHHHHHHHHC	20.85	22210690
481	Ubiquitination	VIRQLMKKEFTLEFS HHHHHHCCCCEEEEE	44.06	22790023
484	Phosphorylation	QLMKKEFTLEFSRDR HHHCCCCEEEEECCC	26.86	24899341
488	Phosphorylation	KEFTLEFSRDRKSMS CCCEEEEECCCCCEE	24.72	23737553
492	Ubiquitination	LEFSRDRKSMSVYCS EEEECCCCCEEEEEC	55.59	22790023
493	Phosphorylation	EFSRDRKSMSVYCSP EEECCCCCEEEEECC	19.72	22210690
495	Phosphorylation	SRDRKSMSVYCSPAK ECCCCCEEEEECCCC	19.61	22210690
497	Phosphorylation	DRKSMSVYCSPAKSS CCCCEEEEECCCCCC	4.66	28464351
499	Phosphorylation	KSMSVYCSPAKSSRA CCEEEEECCCCCCCC	15.37	28464351
502	Ubiquitination	SVYCSPAKSSRAAVG EEEECCCCCCCCCCC	52.96	22790023
503	Phosphorylation	VYCSPAKSSRAAVGN EEECCCCCCCCCCCC	27.45	23375375
504	Phosphorylation	YCSPAKSSRAAVGNK EECCCCCCCCCCCCE	25.82	23375375
511	Ubiquitination	SRAAVGNKMFVKGAP CCCCCCCEEECCCCC	27.99	22790023
515	Ubiquitination	VGNKMFVKGAPEGVI CCCEEECCCCCCCCC	37.78	22790023
527	Phosphorylation	GVIDRCNYVRVGTTR CCCCCCCEEEEECCC	8.02	24719451
532	Phosphorylation	CNYVRVGTTRVPLTG CCEEEEECCCCCCCC	14.47	22817900
533	Phosphorylation	NYVRVGTTRVPLTGP CEEEEECCCCCCCCC	24.60	28464351
538	Phosphorylation	GTTRVPLTGPVKEKI ECCCCCCCCCHHHHH	33.11	28542873
542	Ubiquitination	VPLTGPVKEKIMSVI CCCCCCHHHHHHHHH	57.32	22790023
544	Ubiquitination	LTGPVKEKIMSVIKE CCCCHHHHHHHHHHH	37.68	22790023
547	Phosphorylation	PVKEKIMSVIKEWGT CHHHHHHHHHHHHCC	24.94	22817900
550	Ubiquitination	EKIMSVIKEWGTGRD HHHHHHHHHHCCCHH	45.30	22790023
554	Phosphorylation	SVIKEWGTGRDTLRC HHHHHHCCCHHHHHH	30.07	24719451
569	Phosphorylation	LALATRDTPPKREEM HHHHCCCCCCCCHHH	37.89	28464351
572	Ubiquitination	ATRDTPPKREEMVLD HCCCCCCCCHHHCCC	73.90	22790023
581	Phosphorylation	EEMVLDDSAKFMEYE HHHCCCCHHHHHEEE	32.78	28464351
605	Ubiquitination	GMLDPPRKEVTGSIQ ECCCCCCCCCCHHHE	63.41	22790023
608	Phosphorylation	DPPRKEVTGSIQLCR CCCCCCCCHHHEEHH	26.71	28464351
625	Phosphorylation	GIRVIMITGDNKGTA CCEEEEEECCCCCHH	22.54	28542873
629	Ubiquitination	IMITGDNKGTAIAIC EEEECCCCCHHHHHH	63.48	22790023
643	Phosphorylation	CRRIGIFSENEEVTD HHHHCCCCCCCCCCC	37.28	22817900
649	Phosphorylation	FSENEEVTDRAYTGR CCCCCCCCCCCCCCC	24.05	22418434
654	Phosphorylation	EVTDRAYTGREFDDL CCCCCCCCCCCCCCC	28.86	28464351
712	Ubiquitination	VNDAPALKKAEIGIA CCCCHHHHHCCCEEE	52.63	22790023
713	Ubiquitination	NDAPALKKAEIGIAM CCCHHHHHCCCEEEE	52.69	22790023
722	Phosphorylation	EIGIAMGSGTAVAKT CCEEEECCCHHHHHC	21.64	28542873
741	Phosphorylation	VLADDNFSTIVAAVE HCCCCCCHHHHHHHH	24.39	-
758	Ubiquitination	RAIYNNMKQFIRYLI HHHHHCHHHHHHHHH	44.15	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AT2A1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AT2A1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AT2A1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AT2A1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.