FMNL2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FMNL2_MOUSE
• UniProt AC: A2APV2
• Protein Name: Formin-like protein 2
• Gene Name: Fmnl2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1086
• Subcellular Localization: Cytoplasm.
• Protein Description: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics (By similarity)..
• Protein Sequence: MGNAGSMDSQQTDFKAHNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTMESTVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDIAILPVMASGTLSTGSELAVGNYVGSVPGATTSGPSVPPPPPLPPSSDTSEAAQNGTASPPMSPPPPPPPPPPPPPPPPPPLPGPAAETSPAPPLPPPPPPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKITQKASSKVTLLEANRAKNLAITLRKAGKSADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLLQKMTIMAFIGNFTESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYQQVTLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHNTLLKEFLLHNEGKLKKLQEDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDAKSPSHKSKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITALKKNNITKFPNVHSRVRISSSTPVVEDTQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGNAGSMDS ------CCCCCCCCC	43.96	-
92	Phosphorylation	GYLDPAVTRKKFRRR CCCCHHHHHHHHHHH	38.59	29176673
171	Phosphorylation	KSKPWSRSIEDLHRG CCCCCCCCHHHHHCC	25.47	25521595
179	Phosphorylation	IEDLHRGSNLPSPVG HHHHHCCCCCCCCCC	34.84	26239621
183	Phosphorylation	HRGSNLPSPVGNSVS HCCCCCCCCCCCCCC	35.07	25619855
188	Phosphorylation	LPSPVGNSVSRSGRH CCCCCCCCCCCCCCC	18.62	25619855
190	Phosphorylation	SPVGNSVSRSGRHSA CCCCCCCCCCCCCCC	22.13	25619855
202	Phosphorylation	HSALRYNTLPSRRTL CCCHHCCCCCCCCCC	30.98	22817900
205	Phosphorylation	LRYNTLPSRRTLKNS HHCCCCCCCCCCCCC	37.19	29514104
208	Phosphorylation	NTLPSRRTLKNSRLV CCCCCCCCCCCCCCC	40.76	29514104
355 (in isoform 3)	Ubiquitination	-	57.76	22790023
355	Ubiquitination	GLDEYLDKLKHTESD CHHHHHHHCCCCCCC	57.76	22790023
403	Phosphorylation	EELEENISHLSEKLQ HHHHHHHHHHHHHHH	29.92	28066266
406	Phosphorylation	EENISHLSEKLQDTE HHHHHHHHHHHHHHH	27.54	28066266
450	Phosphorylation	DANTQVHTLRKMVKE HHHHHHHHHHHHHHH	29.42	26824392
466	Phosphorylation	EEAIQRQSTLEKKIH HHHHHHHHHHHHHHH	36.83	29550500
467	Phosphorylation	EAIQRQSTLEKKIHE HHHHHHHHHHHHHHH	30.51	29550500
480	Phosphorylation	HELEKQGTIKIQKKG HHHHHCCCEEEEECC	19.32	29514104
676	Phosphorylation	QGPAIDLSSSKQKIT CCCCCCCCCCCHHHH	28.90	23984901
677	Phosphorylation	GPAIDLSSSKQKITQ CCCCCCCCCCHHHHH	49.18	23984901
678	Phosphorylation	PAIDLSSSKQKITQK CCCCCCCCCHHHHHH	35.41	25521595
687	Phosphorylation	QKITQKASSKVTLLE HHHHHHHHCCEEHHH	37.41	29514104
688	Phosphorylation	KITQKASSKVTLLEA HHHHHHHCCEEHHHH	35.68	25338131
814	Phosphorylation	ASVSIKSSQKLKKIL HHCCCCCHHHHHHHH	26.74	-
1015	Phosphorylation	MEQQDAKSPSHKSKR HHHCCCCCCCHHHHH	33.10	25521595
1017	Phosphorylation	QQDAKSPSHKSKRQQ HCCCCCCCHHHHHHH	51.11	30635358
1071 (in isoform 3)	Phosphorylation	-	13.57	29514104
1075	Phosphorylation	VHSRVRISSSTPVVE CCCCEEECCCCCCEE	13.99	25521595
1076	Phosphorylation	HSRVRISSSTPVVED CCCEEECCCCCCEEC	35.54	21454597
1077	Phosphorylation	SRVRISSSTPVVEDT CCEEECCCCCCEECC	29.91	21454597
1078	Phosphorylation	RVRISSSTPVVEDTQ CEEECCCCCCEECCC	23.27	21454597

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FMNL2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FMNL2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FMNL2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of FMNL2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.