CP17A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CP17A_MOUSE
• UniProt AC: P27786
• Protein Name: Steroid 17-alpha-hydroxylase/17,20 lyase
• Gene Name: Cyp17a1
• Organism: Mus musculus (Mouse).
• Sequence Length: 507
• Subcellular Localization: Membrane .
• Protein Description: Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty..
• Protein Sequence: MWELVGLLLLILAYFFWPKSKTPNAKFPRSLPFLPLVGSLPFLPRRGHMHANFFKLQEKYGPIYSLRLGTTTAVIVGHYQLAREVLVKKGKEFSGRPQMVTLGLLSDQGKGVAFADSSSSWQLHRKLVFSTFSLFRDDQKLEKMICQEANSLCDLILTYDGESRDLSTLIFKSVINIICTICFNISFENKDPILTTIQTFTEGIVDVLGHSDLVDIFPWLKIFPNKNLEMIKEHTKIREKTLVEMFEKCKEKFNSESLSSLTDILIQAKMNAENNNTGEGQDPSVFSDKHILVTVGDIFGAGIETTSSVLNWILAFLVHNPEVKRKIQKEIDQYVGFSRTPSFNDRTHLLMLEATIREVLRIRPVAPLLIPHKANIDSSIGEFAIPKDTHVIINLWALHHDKNEWDQPDRFMPERFLDPTGSHLITPTPSYLPFGAGPRSCIGEALARQELFIFMALLLQRFDFDVSDDKQLPCLVGDPKVVFLIDPFKVKITVRQAWKDAQVEVST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	Phosphorylation	FFKLQEKYGPIYSLR CHHHHHHHCCEEEEE	27.64	24719451
232	Ubiquitination	NKNLEMIKEHTKIRE CCCHHHHHHHHHHHH	41.98	-
235	Phosphorylation	LEMIKEHTKIREKTL HHHHHHHHHHHHHHH	29.29	-
248	Ubiquitination	TLVEMFEKCKEKFNS HHHHHHHHHHHHCCC	39.06	22790023
252	Ubiquitination	MFEKCKEKFNSESLS HHHHHHHHCCCCCHH	35.03	22790023
262	Phosphorylation	SESLSSLTDILIQAK CCCHHHHHHHHHHHH	23.96	29899451
329	Ubiquitination	EVKRKIQKEIDQYVG HHHHHHHHHHHHHCC	61.17	22790023
499	Ubiquitination	ITVRQAWKDAQVEVS EEEEHHHHHCCEEEC	46.32	-
506	Phosphorylation	KDAQVEVST------ HHCCEEECC------	18.20	23140645
507	Phosphorylation	DAQVEVST------- HCCEEECC-------	48.05	25293948

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CP17A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CP17A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CP17A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CP17A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.