MAEL_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAEL_MOUSE
• UniProt AC: Q8BVN9
• Protein Name: Protein maelstrom homolog {ECO:0000305}
• Gene Name: Mael {ECO:0000312|MGI:MGI:2138453}
• Organism: Mus musculus (Mouse).
• Sequence Length: 434
• Subcellular Localization: Cytoplasm . Nucleus . Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Recruited to perinuclear nuage during spermatogenesis. Specifically localizes to piP-bo
• Protein Description: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage..
• Protein Sequence: MPNRRASRNAYYFFVQEKIPELRRRGLPVARVADAIPYCSADWALLREDEKEKYSEMAREWRAAQGKDSGPSEKQKLVSTPLRRPGMLVPKPSISPPDMSNLSIKSDQALLGGIFYFLNIFSHGELPPHCEQRFLPCEIGCVKYSLQEGIMADFHSFIHPGEIPRGFRFHCQAASDSSHKIPISNFEFGHDQATVLQNLYKFIHPNPGNWPPIYCKSDDRARVNWCLKRMERASEIRQDLELLTVEDLVVGIYQQKFLKEPSKTWVRSLLDVAMWDYSSNTRCKWHEENDILFCALAVCKKIAYCISNSLATLFGIQLTGAHVPLQDYEASNSVTPKMVVLDAGRYQKLRVESPGFCHFNSYNQEQRSNTSTGYYPSGVKISGPHSSVRGRGITRLLESISNSSNNIHRFSSCETSLSPYTPQKDGYKPFSSFS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
93	Phosphorylation	GMLVPKPSISPPDMS CCCCCCCCCCCCCCC	41.65	25293948
95	Phosphorylation	LVPKPSISPPDMSNL CCCCCCCCCCCCCCC	34.42	25293948
353	Phosphorylation	YQKLRVESPGFCHFN CEEEEECCCCCCCCC	27.71	25293948
416	Phosphorylation	RFSSCETSLSPYTPQ ECCCCCCCCCCCCCC	12.45	25293948
418	Phosphorylation	SSCETSLSPYTPQKD CCCCCCCCCCCCCCC	18.67	25293948
421	Phosphorylation	ETSLSPYTPQKDGYK CCCCCCCCCCCCCCC	23.72	25293948
434	Phosphorylation	YKPFSSFS------- CCCCCCCC-------	41.06	25293948

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAEL_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAEL_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAEL_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIN3B_MOUSE	Sin3b	physical	16787967
SNF5_MOUSE	Smarcb1	physical	16787967
DDX4_MOUSE	Ddx4	physical	16787967
TDRD1_MOUSE	Tdrd1	physical	16787967
PIWL2_MOUSE	Piwil2	physical	16787967
PIWL1_MOUSE	Piwil1	physical	16787967

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.