MYO3B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYO3B_MOUSE
• UniProt AC: Q1EG27
• Protein Name: Myosin-IIIb
• Gene Name: Myo3b
• Organism: Mus musculus (Mouse).
• Sequence Length: 1305
• Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection, stereocilium .
• Protein Description: Probable actin-based motor with a protein kinase activity (By similarity). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. [PubMed: 26754646 Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments]
• Protein Sequence: MMLGLESLPDPMETWEIIETIGKGTYGKVYKVANKRDGSLAAVKVLDPVSDMDEEIEAEYNILQFLPSHPNVVKFYGMFYKADRCVGGQLWLVLELCNGGSVTELVKGLLRCGKRLDEAVISYILYGALLGLQHLHCHRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFEMHPVKMLFKIPRNPPPTLLHPDSWCEEFNHFISQCLIKDFEKRPSVTHLLDHPFIKGTQGKVLCLQKQLAKVLQDQKHRNPVAKTRHERMHTGRPHRVEDAGKCCLEDDLVNLEVLDEDTIIYWLQKRYADALIYTYVGDILIALNPFQNLSIYSPQFSRLYHGVKRSSNPPHIFASADNAYQCLVTFSKDQCIVISGESGSGKTESAHLIVQHLTFLGKADNQTLRQKILQVNSLVEAFGNARTAINDNSSRFGKYLEMMFTPTGAVMGARISEYLLEKSRVIQQAAGEKNFHIFYYIYAGLYHQKKLAEFRLPEEKPPRYIAGETERVMQDITSKESYRTQFEAIQHCFKIIGFADKEVHSVYRILAGILNIGSIEFAAISSQHQTDKSEVPNPEALENAACVLCISSEELQEALTSHCVVTRGETIVRANTVDRAEDVRDAMSKALYGRLFSWIVNRINTLLQPDKNICSAEDRMNVGILDIFGFEDFQRNSFEQLCINIANEQIQYYFNQHVFALEQMEYKNEGVDAVLVQYEDNRPLLDMFLQKPLGLLALLDEESRFPQGTDQTLVDKFEDNLRCKFFWRPKGVELCFGIQHYAGPVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRAKITASSRSLPPHFSAGRAKVDTLEVIRHPEETTNMKRQTMASYFRYSLMDLLSKMVVGQPHFIRCIKPNDDRKALQFSQDRVLAQLRSTGILETVSIRRQGYSHRIFFEEFVKRYYYLAFRAHQTPPANKESCVAILEKSRLDHWVLGKTKVFLKYYHVEQLNLLLREVMGRVVMLQAYTKGWLGARRYKRAKEKREKGAITIQSAWRGYDARRKLKQRSRRRSESEAHIHTVLQTTPDQKYCPDSGGESNRGHEETSRNCPAEADTDGHPQAQSPPTGCDVTSGHADTAAGYTVAELSVAGTDVSPSLVYHTASAHQRLSPCEDSLKPGSEEGLSQKQRAPRRRCQQPKMLSSPEDTMYYNQLNGTLEYQGSQRKPRKLGQIKVLDGEDQYYKCLSPGACAPEETHSVHPFFFSSSPREDPFAQH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
171	Phosphorylation	GVSAQLTSTRLRRNT CCCEEECCHHHCCCC	21.81	-
178	Phosphorylation	STRLRRNTSVGTPFW CHHHCCCCCCCCCCC	23.99	-
433	Phosphorylation	SGSGKTESAHLIVQH CCCCHHHHHHHHHHH	26.64	28059163
442	Phosphorylation	HLIVQHLTFLGKADN HHHHHHHHHCCCCCC	18.06	28059163
478	Phosphorylation	TAINDNSSRFGKYLE HHCCCCCCHHHHHHH	37.57	23375375
887	Phosphorylation	KITASSRSLPPHFSA EEEECCCCCCCCCCC	47.37	-
918	Phosphorylation	TTNMKRQTMASYFRY HCCCHHHHHHHHHHH	20.81	-
1121	Phosphorylation	QTTPDQKYCPDSGGE ECCCCCCCCCCCCCC	12.00	25777480
1125	Phosphorylation	DQKYCPDSGGESNRG CCCCCCCCCCCCCCC	33.56	25777480
1129	Phosphorylation	CPDSGGESNRGHEET CCCCCCCCCCCCCCC	34.79	25777480
1246	Phosphorylation	YYNQLNGTLEYQGSQ HHHHHCCCEEECCCC	18.49	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
171	S	Phosphorylation	Kinase	MYO3B	Q1EG27	PSP
178	T	Phosphorylation	Kinase	MYO3B	Q1EG27	PSP
887	S	Phosphorylation	Kinase	MYO3B	Q1EG27	PSP
918	T	Phosphorylation	Kinase	MYO3B	Q1EG27	PSP
1246	T	Phosphorylation	Kinase	MYO3B	Q1EG27	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYO3B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYO3B_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MYO3B_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.