MYOM1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYOM1_MOUSE
• UniProt AC: Q62234
• Protein Name: Myomesin-1
• Gene Name: Myom1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1667
• Subcellular Localization: Cytoplasm, myofibril, sarcomere, M line .
• Protein Description: May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. May also contact myosin filaments. Also binds beta-integrins..
• Protein Sequence: MSLPFYQRSHQHYDLSYRNKDLRTTMSHYQQEKKRSAVYTHGSTAYSSRSLAARRQESEAFSQASATSYQQQASQTYSLGASSSSRHSQGSEVSRKTASAYDYGYSHGLTDSSLLLEDYSSKLSPQTKRAKRSLLSGEETGSLPGNYLVPIYSGRQVHISGIRDSEEERIKEAAAYIAQKTLLASEEAIAASKQSTASKQSATSKRTTSTLQREETFEKKSRNIAIREKAEELSLKKTLEETQTYHGKLNEDHLLHAPEFIIKPRSHTVWEKENVKLHCSVAGWPEPRLTWYKNQVPINVHANPGKYIIESRYGMHTLEISKCDFEDTAQYRASAMNVQGELSAYASVVVKRYKGELDESLLRGGVSMPLSFAVTPYGYASKFEIHFDDKFDVSFGREGETMSLGCRVVITPEIKHFQPEVQWYRNGAPVSPSKWVQPHWSGDRATLTFSHLNKEDEGLYTIRVRMGEYYEQYSAYVFVRDADAEIEGAPAAPLDVVSLDANKDYIIISWKQPAVDGGSPILGYFIDKCEVGTDTWSQCNDTPVKFARFPVTGLIEGRSYIFRVRAVNKTGIGLPSRVSEPVAALDPAEKARLKSHPSAPWTGQIIVTEEEPTEGVIPGPPTDLSVTEATRSYVVLSWKPPGQRGHEGIMYFVEKCDVGAENWQRVNTELPVKSPRFALFDLVEGKSYRFRVRCSNSAGVGEPSETTEVTVVGDKLDIPKAPGKIIPSRNTDTSVVVSWEESRDAKELVGYYIEASVVGSGKWEPCNNNPVKGSRFTCHGLTTAQSYIFRVRAVNAAGLSEYSQDSEAIEVKAAIGGGVSPDVWPQLSDTPGGLTDSRGGMNGASPPTSQKDALLGSNPNKPSPPSSPSSRGQKEVSTVSESVQEPLSSPPQEAAPEEEQSQSEPPKKKKDPVAVPSAPYDITCLESFRDSMVLGWKQPDTTGGAEITGYYVNYREVVGEVPGKWREANIKAVSDAAYKISNLKENTLYQFQVSAMNIAGLGAPSTVSECFKCEEWTIAVPGPPHSVKLSEVRKNSLVLQWKPPVYSGRTPVTGYFVDLKEASAKDDQWRGLNEAAIVNKYLRVQGLKEGTSYVFRVRAVNQAGVGKPSDLAGPVVAETRPGTKEVVVSVDDDGVISLNFECDQMTPKSEFVWSKDYVPTEDSPRLEVENKGDKTKMTFKDLGTDDLGTYSCDVTDTDGIASSYLIDEEEMKRLLALSQEHKFPTVPTKSELAVEILEKGQVRFWMQAEKLSSNAKVSYIFNEKEIFEGPKYKMHIDRNTGIIEMFMEKLQDEDEGTYTFQIQDGKATGHSTLVLIGDVYKKLQKEAEFQRQEWIRKQGPHFAEYLSWEVTGECNVLLKCKVANIKKETHIVWYKDEREISVDEKHDFKDGICTLLITEFSKKDAGFYEVILKDDRGKDKSRLKLVDEAFQDLMTEVCKKIALSATDLKIQSTAEGIRLYSFVCYYLDDLKVNWSHNGTGIKYTDRVKSGVTGEQIWLQINEPTPNDKGKYVMELFDGKTGHQKTVDLSGQAFDEAFAEFQRLKQAAIAEKNRARVLGGLPDVVTIQEGKALNLTCNVWGDPPPEVSWLKNEKPLTSDDHCSLKFEAGKTAFFTISGVSTADSGKYGLVVKNKYGSETSDFTVSVFIPEEELRKGAMEPPKGNQKSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLPFYQRS ------CCCCCCCCC	56.93	23737553
6	Phosphorylation	--MSLPFYQRSHQHY --CCCCCCCCCCCCC	10.90	29895711
36	Phosphorylation	YQQEKKRSAVYTHGS HHHHHHHCCEEECCH	30.85	22210690
46	Phosphorylation	YTHGSTAYSSRSLAA EECCHHHHHHHHHHH	13.78	-
47	Phosphorylation	THGSTAYSSRSLAAR ECCHHHHHHHHHHHH	19.46	-
49	Methylation	GSTAYSSRSLAARRQ CHHHHHHHHHHHHHH	29.74	58858631
62	Phosphorylation	RQESEAFSQASATSY HHHHHHHHHHCCHHH	31.70	-
74	Phosphorylation	TSYQQQASQTYSLGA HHHHHHHHCEEECCC	20.79	-
76	Phosphorylation	YQQQASQTYSLGASS HHHHHHCEEECCCCC	16.75	-
88	Phosphorylation	ASSSSRHSQGSEVSR CCCCCCCCCCCHHHH	34.82	23737553
91	Phosphorylation	SSRHSQGSEVSRKTA CCCCCCCCHHHHHHH	27.47	23737553
94	Phosphorylation	HSQGSEVSRKTASAY CCCCCHHHHHHHHHH	24.81	23737553
96	Ubiquitination	QGSEVSRKTASAYDY CCCHHHHHHHHHHCC	40.72	22790023
120	Phosphorylation	SLLLEDYSSKLSPQT HHHHHHHHHCCCHHH	33.06	23737553
121	Phosphorylation	LLLEDYSSKLSPQTK HHHHHHHHCCCHHHH	31.24	23737553
122	Ubiquitination	LLEDYSSKLSPQTKR HHHHHHHCCCHHHHH	47.22	22790023
124	Phosphorylation	EDYSSKLSPQTKRAK HHHHHCCCHHHHHHH	20.78	23737553
127	Phosphorylation	SSKLSPQTKRAKRSL HHCCCHHHHHHHHHH	26.36	23737553
133	Phosphorylation	QTKRAKRSLLSGEET HHHHHHHHHHCCCCC	32.71	23737553
136	Phosphorylation	RAKRSLLSGEETGSL HHHHHHHCCCCCCCC	49.83	23737553
140	Phosphorylation	SLLSGEETGSLPGNY HHHCCCCCCCCCCCE	27.98	23737553
142	Phosphorylation	LSGEETGSLPGNYLV HCCCCCCCCCCCEEE	38.52	23737553
160	Phosphorylation	SGRQVHISGIRDSEE CCCEEEEECCCCCHH	17.18	23737553
165	Phosphorylation	HISGIRDSEEERIKE EEECCCCCHHHHHHH	36.74	23737553
171	Ubiquitination	DSEEERIKEAAAYIA CCHHHHHHHHHHHHH	47.74	22790023
176	Phosphorylation	RIKEAAAYIAQKTLL HHHHHHHHHHHHHHH	7.64	28464351
180	Ubiquitination	AAAYIAQKTLLASEE HHHHHHHHHHHCCHH	31.92	22790023
185	Phosphorylation	AQKTLLASEEAIAAS HHHHHHCCHHHHHHH	35.62	28542873
192	Phosphorylation	SEEAIAASKQSTASK CHHHHHHHCCHHCCC	23.39	28464351
193	Ubiquitination	EEAIAASKQSTASKQ HHHHHHHCCHHCCCC	43.47	22790023
195	Phosphorylation	AIAASKQSTASKQSA HHHHHCCHHCCCCCC	29.67	28464351
208	Phosphorylation	SATSKRTTSTLQREE CCCCCCCHHHHHHHH	24.60	-
209	Phosphorylation	ATSKRTTSTLQREET CCCCCCHHHHHHHHH	26.89	27742792
210	Phosphorylation	TSKRTTSTLQREETF CCCCCHHHHHHHHHH	25.48	27742792
216	Phosphorylation	STLQREETFEKKSRN HHHHHHHHHHHHHHC	32.13	26824392
219	Ubiquitination	QREETFEKKSRNIAI HHHHHHHHHHHCHHH	52.43	22790023
221	Phosphorylation	EETFEKKSRNIAIRE HHHHHHHHHCHHHHH	41.44	21183079
229	Ubiquitination	RNIAIREKAEELSLK HCHHHHHHHHHHCCH	51.77	22790023
237	Ubiquitination	AEELSLKKTLEETQT HHHHCCHHHHHHHCC	64.73	22790023
244	Phosphorylation	KTLEETQTYHGKLNE HHHHHHCCCCCCCCH	25.55	28464351
245	Phosphorylation	TLEETQTYHGKLNED HHHHHCCCCCCCCHH	9.96	28464351
263	Ubiquitination	HAPEFIIKPRSHTVW CCCEEEECCCCCCCE	29.57	22790023
272	Ubiquitination	RSHTVWEKENVKLHC CCCCCEECCCEEEEE	38.59	22790023
292	Phosphorylation	PEPRLTWYKNQVPIN CCCCEEEECCCCCEE	8.53	-
313	Phosphorylation	KYIIESRYGMHTLEI CEEEEECCCEEEEEE	28.25	28464351
353	Phosphorylation	ASVVVKRYKGELDES EEEEEHHHCCCCCHH	20.02	22210690
354	Ubiquitination	SVVVKRYKGELDESL EEEEHHHCCCCCHHH	50.36	22790023
360	Phosphorylation	YKGELDESLLRGGVS HCCCCCHHHHCCCCC	32.16	23737553
367	Phosphorylation	SLLRGGVSMPLSFAV HHHCCCCCCEEEEEE	20.25	23737553
375	Phosphorylation	MPLSFAVTPYGYASK CEEEEEECCCCCEEC	13.83	28464351
377	Phosphorylation	LSFAVTPYGYASKFE EEEEECCCCCEECEE	17.25	28464351
403	Phosphorylation	GREGETMSLGCRVVI CCCCCCEEEEEEEEE	29.09	28464351
406	S-nitrosocysteine	GETMSLGCRVVITPE CCCEEEEEEEEECCC	3.46	-
406	S-nitrosylation	GETMSLGCRVVITPE CCCEEEEEEEEECCC	3.46	21278135
415	Acetylation	VVITPEIKHFQPEVQ EEECCCCHHCCCCCE	36.38	22902405
415	Ubiquitination	VVITPEIKHFQPEVQ EEECCCCHHCCCCCE	36.38	22790023
424	Phosphorylation	FQPEVQWYRNGAPVS CCCCCEECCCCCCCC	4.15	22210690
431	Phosphorylation	YRNGAPVSPSKWVQP CCCCCCCCHHHCCCC	23.54	23375375
433	Phosphorylation	NGAPVSPSKWVQPHW CCCCCCHHHCCCCCC	31.48	22210690
441	Phosphorylation	KWVQPHWSGDRATLT HCCCCCCCCCCEEEE	27.99	28542873
498	Phosphorylation	AAPLDVVSLDANKDY CCCEEEEEEECCCCE	22.00	28464351
519	Phosphorylation	QPAVDGGSPILGYFI CCCCCCCCCCCEEEE	17.81	28542873
528	Ubiquitination	ILGYFIDKCEVGTDT CCEEEEEEEEECCCC	27.72	-
552	Phosphorylation	KFARFPVTGLIEGRS CEEECEECCEECCCE	26.89	28464351
569	Ubiquitination	FRVRAVNKTGIGLPS EEEEEECCCCCCCCC	41.34	22790023
590	Ubiquitination	AALDPAEKARLKSHP CCCCHHHHHHHHCCC	40.70	22790023
655	Ubiquitination	GIMYFVEKCDVGAEN CEEEEEEECCCCCCH	30.36	22790023
673	Ubiquitination	VNTELPVKSPRFALF CCCCCCCCCCEEEEE	53.45	22790023
674	Phosphorylation	NTELPVKSPRFALFD CCCCCCCCCEEEEEE	22.88	22210690
686	Ubiquitination	LFDLVEGKSYRFRVR EEEECCCCEEEEEEE	30.70	22790023
695	Phosphorylation	YRFRVRCSNSAGVGE EEEEEEECCCCCCCC	24.21	28464351
706	Phosphorylation	GVGEPSETTEVTVVG CCCCCCCCEEEEEEE	32.37	28464351
715	Ubiquitination	EVTVVGDKLDIPKAP EEEEEECCCCCCCCC	41.97	22790023
752	Phosphorylation	AKELVGYYIEASVVG HHHHHEEEEEEEEEC	6.07	-
777	Phosphorylation	PVKGSRFTCHGLTTA CCCCCCEEECCCCCC	11.50	28542873
778	S-nitrosocysteine	VKGSRFTCHGLTTAQ CCCCCEEECCCCCCH	1.89	-
778	S-nitrosylation	VKGSRFTCHGLTTAQ CCCCCEEECCCCCCH	1.89	21278135
783	Phosphorylation	FTCHGLTTAQSYIFR EEECCCCCCHHHEEE	27.95	28464351
786	Phosphorylation	HGLTTAQSYIFRVRA CCCCCCHHHEEEEEE	20.10	28464351
787	Phosphorylation	GLTTAQSYIFRVRAV CCCCCHHHEEEEEEE	7.63	21183079
802	Phosphorylation	NAAGLSEYSQDSEAI CCCCCCCCCCCCCCE	14.30	28464351
802 (in isoform 2)	Phosphorylation	-	14.30	28464351
820	Phosphorylation	AAIGGGVSPDVWPQL HHHCCCCCCCCCCCC	20.75	23737553
822 (in isoform 2)	Phosphorylation	-	47.83	28464351
857	Phosphorylation	QKDALLGSNPNKPSP HHHHHCCCCCCCCCC	49.43	27742792
863	Phosphorylation	GSNPNKPSPPSSPSS CCCCCCCCCCCCCCC	51.56	26824392
866	Phosphorylation	PNKPSPPSSPSSRGQ CCCCCCCCCCCCCCC	59.26	23737553
867	Phosphorylation	NKPSPPSSPSSRGQK CCCCCCCCCCCCCCC	34.28	23737553
869	Phosphorylation	PSPPSSPSSRGQKEV CCCCCCCCCCCCCEE	34.32	23737553
870	Phosphorylation	SPPSSPSSRGQKEVS CCCCCCCCCCCCEEE	43.76	23737553
941	Phosphorylation	LGWKQPDTTGGAEIT EECCCCCCCCCCEEE	33.74	21183079
964	Ubiquitination	VVGEVPGKWREANIK EEECCCCCHHHHHHH	36.69	22790023
974	Phosphorylation	EANIKAVSDAAYKIS HHHHHHHHHHCHHHH	26.79	28464351
978	Phosphorylation	KAVSDAAYKISNLKE HHHHHHCHHHHCCCC	15.58	28464351
979	Ubiquitination	AVSDAAYKISNLKEN HHHHHCHHHHCCCCC	34.63	22790023
981	Phosphorylation	SDAAYKISNLKENTL HHHCHHHHCCCCCCE	31.77	28464351
1026	Phosphorylation	AVPGPPHSVKLSEVR ECCCCCCEEEHHHHH	27.07	23375375
1036	Phosphorylation	LSEVRKNSLVLQWKP HHHHHCCCEEEEECC	23.92	23737553
1046	Phosphorylation	LQWKPPVYSGRTPVT EEECCCCCCCCCCCE	15.92	21183079
1047	Phosphorylation	QWKPPVYSGRTPVTG EECCCCCCCCCCCEE	23.25	28542873
1060	Ubiquitination	TGYFVDLKEASAKDD EEEEEEHHHHCCCCC	46.93	22790023
1063	Phosphorylation	FVDLKEASAKDDQWR EEEHHHHCCCCCCCC	36.62	22210690
1080	Ubiquitination	NEAAIVNKYLRVQGL CHHHHHHHHHHHCCC	34.46	22790023
1088	Ubiquitination	YLRVQGLKEGTSYVF HHHHCCCCCCCEEEE	62.01	22790023
1155	Ubiquitination	KSEFVWSKDYVPTED CCCEECCCCCCCCCC	37.05	22790023
1157	Phosphorylation	EFVWSKDYVPTEDSP CEECCCCCCCCCCCC	16.44	27742792
1160	Phosphorylation	WSKDYVPTEDSPRLE CCCCCCCCCCCCCEE	42.24	27742792
1163	Phosphorylation	DYVPTEDSPRLEVEN CCCCCCCCCCEEEEE	12.99	23737553
1171	Ubiquitination	PRLEVENKGDKTKMT CCEEEEECCCCCEEE	55.79	22790023
1218	Phosphorylation	MKRLLALSQEHKFPT HHHHHHHHHHCCCCC	28.10	28464351
1230	Phosphorylation	FPTVPTKSELAVEIL CCCCCCCCHHHHHHH	40.08	22210690
1250	Ubiquitination	RFWMQAEKLSSNAKV EEEEEHHHCCCCCEE	57.60	22790023
1256	Ubiquitination	EKLSSNAKVSYIFNE HHCCCCCEEEEEECC	35.64	22790023
1264	Ubiquitination	VSYIFNEKEIFEGPK EEEEECCHHHHCCCC	58.16	22790023
1273	Acetylation	IFEGPKYKMHIDRNT HHCCCCEEEEEECCC	30.08	15613343
1321	Acetylation	VLIGDVYKKLQKEAE EEEHHHHHHHHHHHH	47.02	19863645
1325	Ubiquitination	DVYKKLQKEAEFQRQ HHHHHHHHHHHHHHH	70.13	22790023
1374	Phosphorylation	KETHIVWYKDEREIS EEEEEEEECCCCEEC	9.54	22210690
1381	Phosphorylation	YKDEREISVDEKHDF ECCCCEECCCCCCCC	20.82	23375375
1394	Phosphorylation	DFKDGICTLLITEFS CCCCCEEEEEEEECC	23.76	-
1444	Phosphorylation	VCKKIALSATDLKIQ HHHHHHHCCCCCEEE	21.79	28464351
1452	Phosphorylation	ATDLKIQSTAEGIRL CCCCEEEECCHHHHH	32.81	28464351
1475	Phosphorylation	DDLKVNWSHNGTGIK CCCCCCCCCCCCCCC	11.23	28542873
1482	Ubiquitination	SHNGTGIKYTDRVKS CCCCCCCCCCCCCCC	43.36	22790023
1510	Ubiquitination	PTPNDKGKYVMELFD CCCCCCCCEEEEEEC	40.17	22790023
1519	Ubiquitination	VMELFDGKTGHQKTV EEEEECCCCCCEEEE	53.85	22790023
1520	Phosphorylation	MELFDGKTGHQKTVD EEEECCCCCCEEEEE	45.48	28464351
1596	Phosphorylation	LKNEKPLTSDDHCSL EECCCCCCCCCCCEE	38.34	28464351
1597	Phosphorylation	KNEKPLTSDDHCSLK ECCCCCCCCCCCEEE	49.04	28464351
1601	S-nitrosocysteine	PLTSDDHCSLKFEAG CCCCCCCCEEEEECC	7.01	-
1601	S-nitrosylation	PLTSDDHCSLKFEAG CCCCCCCCEEEEECC	7.01	21278135
1619	Phosphorylation	FFTISGVSTADSGKY EEEEECEECCCCCCE	22.77	28464351
1625	Acetylation	VSTADSGKYGLVVKN EECCCCCCEEEEEEE	39.85	7613167
1634	Phosphorylation	GLVVKNKYGSETSDF EEEEEECCCCCCCCE	34.97	28464351
1636	Phosphorylation	VVKNKYGSETSDFTV EEEECCCCCCCCEEE	34.31	28464351

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYOM1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYOM1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYOM1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MYOM1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.