URP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: URP2_MOUSE
• UniProt AC: Q8K1B8
• Protein Name: Fermitin family homolog 3
• Gene Name: Fermt3
• Organism: Mus musculus (Mouse).
• Sequence Length: 665
• Subcellular Localization: Cell projection, podosome . Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells.
• Protein Description: Plays a central role in cell adhesion in hematopoietic cells (By similarity). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). [PubMed: 18278053 Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells]
• Protein Sequence: MAGMKTASGDYIDSSWELRVFVGEEDPEAQSVTLRVTGESHIGGVLLKIVEEINRKQDWSDHAIWWEQKRQWLLQTHWTLDKYGILADARLFFGPQHRPVILRLPNRRVLRLRASFSKPLFQTVAAICRLLSIRHPEELSLLRAPEKKEKKKKEKEPEEEVHDLTKVVLAGGVAPTLFRGMPAHFSDSAQTEACYHMLSRPQPAPDPLLLQRLPRPSSLPDKTQLHSRWLDSSRCLMQQGIKAGDVLWLRFKYYSFFDLDPKTDPVRLTQLYEQARWDLLTEEIDCTEEEMMVFAALQYHINKLTLSGDVGELASGDLGLDDLDAALNNLEVKLKGSAPSDMLDSLTTIPELKDHLRIFRPRKLTLKGYRQYWVVFKDTTLSYYKSQDEAPGDPTQQLNLKGCEVVPDVNVSGQKFCIKLLVPSPEGMSEIYLRCQDEQQYAQWMAACRLASKGRTMADSSYASEVQAILAFLSLQRAGGSNGGSGNKPQGPEAPAEGLNPYGLVAPRFQRKFKAKQLTPRILEAHQNVAQLSLTEAQLRFIQAWQSLPDFGISYVMVRFKGSRKDEILGIANNRLIRIDLAVGDVVKTWRFSNMRQWNVNWDIRQVAIEFDEHINVAFSCVSASCRIVHEYIGGYIFLSTRERARGEELDEDLFLQLTGGHEAF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MAGMKTASGDYID --CCCCCCCCCCCCC	19.70	24704852
8	Phosphorylation	MAGMKTASGDYIDSS CCCCCCCCCCCCCCC	37.11	25521595
11	Phosphorylation	MKTASGDYIDSSWEL CCCCCCCCCCCCEEE	15.34	25159016
33	Phosphorylation	DPEAQSVTLRVTGES CCCCCEEEEEEECCC	17.69	28059163
194	Glutathionylation	DSAQTEACYHMLSRP CCHHHHHHHHHHHCC	1.63	24333276
217	Phosphorylation	LQRLPRPSSLPDKTQ HHCCCCCCCCCCCCH	45.87	24719451
218	Phosphorylation	QRLPRPSSLPDKTQL HCCCCCCCCCCCCHH	46.75	22817900
235	Glutathionylation	RWLDSSRCLMQQGIK HHHHHHHHHHHCCCC	3.92	24333276
337	Phosphorylation	LEVKLKGSAPSDMLD CEEEECCCCCHHHHH	35.10	21183079
340	Phosphorylation	KLKGSAPSDMLDSLT EECCCCCHHHHHHHC	35.06	22942356
345	Phosphorylation	APSDMLDSLTTIPEL CCHHHHHHHCCCHHH	24.53	22942356
365	Phosphorylation	IFRPRKLTLKGYRQY CCCCCEEEECCEEEE	29.47	24719451
369	Phosphorylation	RKLTLKGYRQYWVVF CEEEECCEEEEEEEE	7.92	-
372	Phosphorylation	TLKGYRQYWVVFKDT EECCEEEEEEEEECC	7.38	26026062
403	Glutathionylation	QQLNLKGCEVVPDVN CCCCCCCCEECCCCC	3.24	24333276
432	Phosphorylation	PEGMSEIYLRCQDEQ CCCCCEEHHCCCCHH	5.53	-
485	Phosphorylation	AGGSNGGSGNKPQGP CCCCCCCCCCCCCCC	40.36	28285833
502	Phosphorylation	PAEGLNPYGLVAPRF CCCCCCCCCCCCHHH	23.24	22817900
589	Phosphorylation	AVGDVVKTWRFSNMR ECCHHEEEEECCCCC	15.40	22817900
593	Phosphorylation	VVKTWRFSNMRQWNV HEEEEECCCCCCCCC	22.57	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of URP2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of URP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of URP2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of URP2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.