| UniProt ID | TMEDA_MOUSE | |
|---|---|---|
| UniProt AC | Q9D1D4 | |
| Protein Name | Transmembrane emp24 domain-containing protein 10 | |
| Gene Name | Tmed10 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 219 | |
| Subcellular Localization |
Golgi apparatus, cis-Golgi network membrane Single-pass type I membrane protein. Melanosome. Endoplasmic reticulum membrane Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane Single-pass type I membrane |
|
| Protein Description | Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus (By similarity).. | |
| Protein Sequence | MSGLFGPLSRPGPLPSAWLFLLLLGPSSVLGISFHLPVNSRKCLREEIHKDLLVTGAYEITDQSGGAGGLRTHLKITDSAGHILYAKEDATKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEAKNYEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTRVLYFSIFSMFCLIGLATWQVFYLRRFFKAKKLIE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | SGLFGPLSRPGPLPS CCCCCCCCCCCCCCH | 39.29 | 25266776 | |
| 43 | S-palmitoylation | LPVNSRKCLREEIHK CCCCCCHHHHHHHHH | 4.15 | 26165157 | |
| 87 | Succinylation | AGHILYAKEDATKGK CCCEEEEECCCCCCE | 42.44 | 23954790 | |
| 133 | Succinylation | MKHGVEAKNYEEIAK CCCCCCCCCHHHHHH | 46.70 | 23954790 | |
| 140 | Acetylation | KNYEEIAKVEKLKPL CCHHHHHHHHHCCCH | 57.50 | 23954790 | |
| 171 | Methylation | DFAYMKKREEEMRDT HHHHHHHHHHHHHCC | 51.55 | - | |
| 176 | Methylation | KKREEEMRDTNESTN HHHHHHHHCCCCCCC | 51.38 | - | |
| 179 | N-linked_Glycosylation | EEEMRDTNESTNTRV HHHHHCCCCCCCHHH | 45.57 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TMEDA_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TMEDA_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TMEDA_MOUSE !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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