MIC13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MIC13_HUMAN
• UniProt AC: Q5XKP0
• Protein Name: MICOS complex subunit MIC13 {ECO:0000305}
• Gene Name: MIC13 {ECO:0000303|PubMed:25997101}
• Organism: Homo sapiens (Human).
• Sequence Length: 118
• Subcellular Localization: Mitochondrion inner membrane ; Single-pass membrane protein . Enriched at crista junctions.
• Protein Description: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MINOS1/MIC10 into the MICOS complex..
• Protein Sequence: MVARVWSLMRFLIKGSVAGGAVYLVYDQELLGPSDKSQAALQKAGEVVPPAMYQFSQYVCQQTGLQIPQLPAPPKIYFPIRDSWNAGIMTVMSALSVAPSKAREYSKEGWEYVKARTK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
77	Phosphorylation	LPAPPKIYFPIRDSW CCCCCCEEEECCCCC		26437602
101	Ubiquitination	ALSVAPSKAREYSKE HHHCCCHHHHHHHHH		21890473
107	Ubiquitination	SKAREYSKEGWEYVK HHHHHHHHHHHHHHH		21890473
107	2-Hydroxyisobutyrylation	SKAREYSKEGWEYVK HHHHHHHHHHHHHHH		-
123	Ubiquitination	RTK------------ HCC------------		-
129	Ubiquitination	------------------ ------------------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MIC13_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MIC13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MIC13_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RM24_HUMAN	MRPL24	physical	22939629
MIC25_HUMAN	CHCHD6	physical	27499296
MTX2_HUMAN	MTX2	physical	27499296
MIC27_HUMAN	APOOL	physical	27499296
DJC11_HUMAN	DNAJC11	physical	27499296
SAM50_HUMAN	SAMM50	physical	27499296
MIC26_HUMAN	APOO	physical	27499296
MIC19_HUMAN	CHCHD3	physical	27499296
MTX1_HUMAN	MTX1	physical	27499296
MIC60_HUMAN	IMMT	physical	27499296
STML2_HUMAN	STOML2	physical	27499296
CYC_HUMAN	CYCS	physical	27499296

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.