NCF2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NCF2_MOUSE
• UniProt AC: O70145
• Protein Name: Neutrophil cytosol factor 2
• Gene Name: Ncf2 {ECO:0000312|MGI:MGI:97284}
• Organism: Mus musculus (Mouse).
• Sequence Length: 525
• Subcellular Localization: Cytoplasm .
• Protein Description: NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production)..
• Protein Sequence: MSLAEAIRLWNEGVLAADKKDWKGALEAFSEVQDPHSRICFNIGCVNTILENLQAAEQAFTKSINRDKHSAVAYFQRGMLYYRMEKYDLAIKDLKEALTQLRGNQLIDYKILGLQFKLFACEVLYNIALMHAKKEEWKKAEEQLALATNMKSEPRHSKIDKAMESIWKQKLFEPVVIPVGRLFRPNERQVAQLAKKDYLGKATVVASVVHQDNFSGFAPLQPQSAEPPPRPKTPEIFRALEGEAHRVLFGFVPETPEELQVMPGNIVFVLKKGSDNWATVMFNGQKGLVPCNYLEPVELRIHPQSQPQEDTSPESDIPPPPNSSPPGRLQLSPGHKQKEPKELKLSVPMPYMLKVHYKYTVVMETRLGLPYSQLRNMVSKKLALSPEHTKLSYRRRDSHELLLLSEESMKDAWGQVKNYCLTLWCEHTVGDQGLIDEPIQRENSDASKQTTEPQPKEGTQVVAIFSYEAAQPEDLEFVEGDVILVLSHVNEEWLEGECKGKVGIFPKAFVEGCAAKNLEGIPREV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
157	Phosphorylation	MKSEPRHSKIDKAME CCCCCCHHHHHHHHH	32.36	24719451
203	Phosphorylation	KDYLGKATVVASVVH HCCCCCCEEEEEEEC	20.99	25367039
207	Phosphorylation	GKATVVASVVHQDNF CCCEEEEEEECCCCC	17.05	25367039
215	Phosphorylation	VVHQDNFSGFAPLQP EECCCCCCCCCCCCC	38.98	22345495
224	Phosphorylation	FAPLQPQSAEPPPRP CCCCCCCCCCCCCCC	41.08	26745281
233	Phosphorylation	EPPPRPKTPEIFRAL CCCCCCCCHHHHHHH	28.92	26824392
291	S-nitrosocysteine	GQKGLVPCNYLEPVE CCCCEEECCCCEEEE	4.00	-
291	S-nitrosylation	GQKGLVPCNYLEPVE CCCCEEECCCCEEEE	4.00	22178444
291	Glutathionylation	GQKGLVPCNYLEPVE CCCCEEECCCCEEEE	4.00	24333276
305	Phosphorylation	ELRIHPQSQPQEDTS EEEECCCCCCCCCCC	48.56	23459991
311	Phosphorylation	QSQPQEDTSPESDIP CCCCCCCCCCCCCCC	45.49	26026062
312	Phosphorylation	SQPQEDTSPESDIPP CCCCCCCCCCCCCCC	38.70	26824392
315	Phosphorylation	QEDTSPESDIPPPPN CCCCCCCCCCCCCCC	44.20	26745281
323	Phosphorylation	DIPPPPNSSPPGRLQ CCCCCCCCCCCCCCC	50.42	22942356
324	Phosphorylation	IPPPPNSSPPGRLQL CCCCCCCCCCCCCCC	41.58	22942356
332	Phosphorylation	PPGRLQLSPGHKQKE CCCCCCCCCCCCCCC	18.84	26824392
354	Ubiquitination	VPMPYMLKVHYKYTV CCCCEEEEEEEEEEE	15.50	-
357	Phosphorylation	PYMLKVHYKYTVVME CEEEEEEEEEEEEEE	14.53	-
359	Phosphorylation	MLKVHYKYTVVMETR EEEEEEEEEEEEEEE	9.52	25367039
360	Phosphorylation	LKVHYKYTVVMETRL EEEEEEEEEEEEEEC	11.50	25367039
385	Phosphorylation	VSKKLALSPEHTKLS HHHHHCCCCCHHCCE	23.72	26745281
389	Phosphorylation	LALSPEHTKLSYRRR HCCCCCHHCCEEECC	31.83	26745281
390	Acetylation	ALSPEHTKLSYRRRD CCCCCHHCCEEECCC	37.03	7631943
398	Phosphorylation	LSYRRRDSHELLLLS CEEECCCHHHEEEEC	19.63	22817900
444	Phosphorylation	EPIQRENSDASKQTT CCCCCCCCCCCCCCC	29.78	30635358
513	Glutathionylation	PKAFVEGCAAKNLEG CHHHHHHHHHHCCCC	1.79	24333276

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NCF2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NCF2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NCF2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRDX6_MOUSE	Prdx6	physical	23401562

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.