dbPTM

LMAN2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LMAN2_MOUSE
UniProt AC	Q9DBH5
Protein Name	Vesicular integral-membrane protein VIP36
Gene Name	Lman2
Organism	Mus musculus (Mouse).
Sequence Length	358
Subcellular Localization	Golgi apparatus membrane Single-pass type I membrane protein.
Protein Description	Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity)..
Protein Sequence	MAAEAWLWRWGWGWGQRCPGRPGLPGPGPSPTTFLHLLLLLGPVAADITDGNSEHLKREHSLIKPYQGVGSSSMPLWDFQGSTMLTSQYVRLTPDERSKEGSIWNHQPCFLKDWEMHVHFKVHGTGKKNLHGDGIALWYTRDRLVPGPVFGSKDNFHGLAIFLDTYPNDETTERVFPYISVMVNNGSLSYDHSKDGRWSELAGCTADFRNRDHDTFLAVRYSRGRLTVMTDLEDKNEWKNCIDITGVRLPTGYYFGASAGTGDLSDNHDIISIKLFQLTVERTPEEESIDWTKIEPGVNFLKSPKDNVDDPTGNFRNGPLTGWRVFLLLLCALLGVVVCAVVGAVVFQKRQERNKRFY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
185	N-linked_Glycosylation	YISVMVNNGSLSYDH EEEEEEECCCCCEEC	29.98	-
303	Phosphorylation	PGVNFLKSPKDNVDD CCCCCCCCCCCCCCC	39.05	28066266
305	Ubiquitination	VNFLKSPKDNVDDPT CCCCCCCCCCCCCCC	69.86	27667366
305	Succinylation	VNFLKSPKDNVDDPT CCCCCCCCCCCCCCC	69.86	23954790

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LMAN2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LMAN2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LMAN2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of LMAN2_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LMAN2_MOUSE

Related Literatures of Post-Translational Modification