AL3A2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AL3A2_MOUSE
• UniProt AC: P47740
• Protein Name: Fatty aldehyde dehydrogenase
• Gene Name: Aldh3a2
• Organism: Mus musculus (Mouse).
• Sequence Length: 484
• Subcellular Localization: Membrane . Microsome membrane ; Single-pass membrane protein . Endoplasmic reticulum membrane ; Single-pass membrane protein ; Cytoplasmic side .
• Protein Description: Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. [PubMed: 25286108 Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid]
• Protein Sequence: MERQVLRLRQAFRSGRSRPLRFRLQQLEALRRMVQEREKEILAAIAADLSKSELNAYSHEVITILGEIDFMLGNLPELASARPAKKNLLTMMDEAYVQPEPLGVVLIIGAWNYPFVLTMQPLVGAIAAGNAAIVKPSELSENTAKILAELLPQYLDQDLYAIVNGGIPETTELLKQRFDHILYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDRDCDLDVACRRIAWGKYMNCGQTCIAPDYILCEASLQNQIVQKIKETVKDFYGENIKASPDYERIINLRHFKRLQSLLKGQKIAFGGEMDEATRYLAPTILTDVDPNSKVMQEEIFGPILPIVSVKNVDEAINFINDREKPLALYVFSRNNKLIKRVIDETSSGGVTGNDVIMHFTVNSLPFGGVGASGMGAYHGKYSFDTFSHQRPCLLKGLKGESVNKLRYPPNSESKVSWAKFFLLKQFNKGRLGMLLFVCLVAVAAVIVKDQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Ubiquitination	RMVQEREKEILAAIA HHHHHHHHHHHHHHH	57.17	-
214	S-palmitoylation	ELGGKSPCYIDRDCD EECCCCCCCCCCCCC	6.33	28526873
220	S-palmitoylation	PCYIDRDCDLDVACR CCCCCCCCCCHHHHH	6.11	28526873
226	S-palmitoylation	DCDLDVACRRIAWGK CCCCHHHHHHHHCCC	2.78	28526873
246	Phosphorylation	QTCIAPDYILCEASL CCEECCCCEEEEHHH	8.50	23140645
252	Phosphorylation	DYILCEASLQNQIVQ CCEEEEHHHHHHHHH	14.27	23140645
260	Acetylation	LQNQIVQKIKETVKD HHHHHHHHHHHHHHH	44.87	2388205
262	Ubiquitination	NQIVQKIKETVKDFY HHHHHHHHHHHHHHH	55.13	-
266	Acetylation	QKIKETVKDFYGENI HHHHHHHHHHHCCCC	49.92	23864654
266	Succinylation	QKIKETVKDFYGENI HHHHHHHHHHHCCCC	49.92	23954790
274	Succinylation	DFYGENIKASPDYER HHHCCCCCCCCCHHH	55.16	23954790
274	Ubiquitination	DFYGENIKASPDYER HHHCCCCCCCCCHHH	55.16	-
274	Acetylation	DFYGENIKASPDYER HHHCCCCCCCCCHHH	55.16	23864654
276	Phosphorylation	YGENIKASPDYERII HCCCCCCCCCHHHHH	17.19	51459425
293	Phosphorylation	RHFKRLQSLLKGQKI HHHHHHHHHHCCCCE	40.02	22146711
296	Acetylation	KRLQSLLKGQKIAFG HHHHHHHCCCCEECC	65.67	23864654
296	Succinylation	KRLQSLLKGQKIAFG HHHHHHHCCCCEECC	65.67	23954790
296	Malonylation	KRLQSLLKGQKIAFG HHHHHHHCCCCEECC	65.67	26320211
296	Ubiquitination	KRLQSLLKGQKIAFG HHHHHHHCCCCEECC	65.67	-
299	Malonylation	QSLLKGQKIAFGGEM HHHHCCCCEECCCCC	44.67	26320211
299	Ubiquitination	QSLLKGQKIAFGGEM HHHHCCCCEECCCCC	44.67	-
325	Phosphorylation	LTDVDPNSKVMQEEI CCCCCCCCHHHHHHH	31.83	81112103
326	Malonylation	TDVDPNSKVMQEEIF CCCCCCCHHHHHHHH	48.65	26073543
343	Acetylation	ILPIVSVKNVDEAIN CEEEEEECCHHHHHH	43.69	23954790
357	Ubiquitination	NFINDREKPLALYVF HHCCCCCCCEEEEEE	46.34	-
369	Acetylation	YVFSRNNKLIKRVID EEEECCCEEHHHHHH	55.95	23864654
434	Phosphorylation	LKGLKGESVNKLRYP CCCCCCCCCCCCCCC	39.39	29176673
457	Succinylation	WAKFFLLKQFNKGRL HHHHHHHHHHCCCCH	55.80	23954790

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AL3A2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AL3A2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AL3A2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AL3A2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.