| UniProt ID | MIC27_MOUSE | |
|---|---|---|
| UniProt AC | Q78IK4 | |
| Protein Name | MICOS complex subunit Mic27 | |
| Gene Name | Apool | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 265 | |
| Subcellular Localization |
Mitochondrion inner membrane Multi-pass membrane protein . Mitochondrion . |
|
| Protein Description | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function.. | |
| Protein Sequence | MAAFRMGKLTTIPAGLIYASINVRLAKEEEPKKQLVRPDQLPIYTAPPLHSKYVEEQPGNLQRGFASIRTTTVYYIGWCKSIYLFMKNGVMDTVQFGKDAYVYLKNPPQDFLPKMGVITASGLAGLLSARKGSRFKKIAYPLGLATLGATVCYPAQSVIIAKITGKKAYATSQQIFQAIKSLWTQKSENESLPEPKEESKEGRSDEIHASLPDLKHSVSLPKELASATVIKSESTSGTTQFIPDPKLMDHGQSHPDDKDMYSTRS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 27 | Acetylation | SINVRLAKEEEPKKQ EHHHEECCCCCCHHC | 23201123 | ||
| 51 | Phosphorylation | YTAPPLHSKYVEEQP ECCCCCCHHHCCCCC | 15345747 | ||
| 121 | Phosphorylation | KMGVITASGLAGLLS HCCEEEHHHHHHHHH | 24719451 | ||
| 152 | S-nitrosocysteine | ATLGATVCYPAQSVI CCCCCCEEEECCCEE | - | ||
| 204 | Phosphorylation | EESKEGRSDEIHASL HHCCCCCCCCHHHCC | 25338131 | ||
| 210 | Phosphorylation | RSDEIHASLPDLKHS CCCCHHHCCCCHHHC | 28066266 | ||
| 217 | Phosphorylation | SLPDLKHSVSLPKEL CCCCHHHCCCCCHHH | 25159016 | ||
| 219 | Phosphorylation | PDLKHSVSLPKELAS CCHHHCCCCCHHHHC | 25159016 | ||
| 226 | Phosphorylation | SLPKELASATVIKSE CCCHHHHCCEEEEEE | 29899451 | ||
| 232 | Phosphorylation | ASATVIKSESTSGTT HCCEEEEEECCCCCC | 27742792 | ||
| 234 | Phosphorylation | ATVIKSESTSGTTQF CEEEEEECCCCCCEE | 25521595 | ||
| 235 | Phosphorylation | TVIKSESTSGTTQFI EEEEEECCCCCCEEC | 27742792 | ||
| 236 | Phosphorylation | VIKSESTSGTTQFIP EEEEECCCCCCEECC | 27742792 | ||
| 238 | Phosphorylation | KSESTSGTTQFIPDP EEECCCCCCEECCCH | 27742792 | ||
| 239 | Phosphorylation | SESTSGTTQFIPDPK EECCCCCCEECCCHH | 27742792 | ||
| 253 | Phosphorylation | KLMDHGQSHPDDKDM HHHCCCCCCCCCHHC | 27742792 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MIC27_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MIC27_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MIC27_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of MIC27_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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