PO121_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PO121_MOUSE
• UniProt AC: Q8K3Z9
• Protein Name: Nuclear envelope pore membrane protein POM 121
• Gene Name: Pom121
• Organism: Mus musculus (Mouse).
• Sequence Length: 1200
• Subcellular Localization: Nucleus, nuclear pore complex. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase..
• Protein Description: Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL) (By similarity)..
• Protein Sequence: MSPAAAAADGGERRRPPLGGREGRSRARGYGGPAGAAALGLALLGLALYLVPAAAALAWLAVGASAAWWGLSREPRGPRALSSFVRDARRHPRPALTASPPPAKSPVNGSLCEPRSPLGGPDPAELLLMGSYLGKPGPPEPALRQDPRERPGRRPPARSPPPASAVQRVHHVYPALPTPLLRPSRRPPHRDCGPLSSRFVITPRRRYPIQQAQYSLLGALPTVCWNGGHKKAVLSPRNSRMVCSPVTVRIAPPDSKLFRSSMSEQILDTTLSSPSSNAPDPCAKETVLNALKEKKKRTVAEEDQLHLDGQENKRRRHDSGGSGHSAFEPLVANGVPAAFVPKPGSLKRSLASQSSDDHLNKRSRTSSVSSLASACTGGIPSSSRNAITSSYSSTRGISQLWKRSGPTSSPFSSPASSRSQTPERPAKKTREEEPCQQSSSSPPLVTDKESPGEKVTDTTTGKQQSSWTSPPTPGSSGQRKRKIQLLPSRRGDQLTLPPPPELGYSITAEDLDMERKASLQWFNKVLEDKPDDASASATDGPPSTSPPFTFTLPAVGPAASPASLPAPSSNPLLESLKKMQESPAPSSSEPAEAATVAAPSPPKTPSLLAPLVSPLAGPLASTSSDSKPAATFLGLASASSITPLTDSKSSGVSQAEQSVSTPASTASSPTPKPSMLFGMLSPPASSSSLATPAPACASPMFKPIFPATPKSESDSPLPSSSSAATTASSSTAPPTAASTTPTFKPIFDKMEPFTAMPLSTPFSLKQTTATATTTATSAPLFTGLGTATSTVASGTAASASKPVFGFGVTTAASTASSTMTSTSQSVLFGGAPPVTTSSSAPALASIFQFGKPLAPAASAAGTSFSQPLASSTQTAASNSGFSGFGSTLTTSTSAPATTSQPTLTFSNTVTPTFNIPFSSSAKPALPTYPGANSQPTFGATDGATKPALAPSFGSSFTFGNSVASAPSAAPAPATFGSAAQPAFGGLKAAASTFGAPASTQPAFGSTTSVFSFGSATTSGFGAAATAATTTQTTNSGSSSSLFGSSAPSPFTFGGSAAPAGSGGFGLSATPGTSSTSGTFSFGSGQSGTPGTTTSFGSLSQNTLGAPSQGSPFAFSVGSTPESKPVFGGTSTPTFGQSAPAPGVGTTGSSLSFGASSTPAQGFVGVGPFGSAAPSFSIGAGSKTPGARQRLQARRQHTRKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSPAAAAAD ------CCHHHHHCC	34.25	28066266
82	Phosphorylation	PRGPRALSSFVRDAR CCCHHHHHHHHHHHH	22.27	25159016
83	Phosphorylation	RGPRALSSFVRDARR CCHHHHHHHHHHHHH	28.72	25159016
99	Phosphorylation	PRPALTASPPPAKSP CCCCCCCCCCCCCCC	32.48	28066266
110	Phosphorylation	AKSPVNGSLCEPRSP CCCCCCCCCCCCCCC	25.33	27566939
116	Phosphorylation	GSLCEPRSPLGGPDP CCCCCCCCCCCCCCH	34.88	29514104
159	Phosphorylation	GRRPPARSPPPASAV CCCCCCCCCCCCHHH	43.81	27149854
164	Phosphorylation	ARSPPPASAVQRVHH CCCCCCCHHHHHHHH	34.44	25266776
202	Phosphorylation	LSSRFVITPRRRYPI CCCCEEECCCCCCCH	12.87	22817900
235	Phosphorylation	GHKKAVLSPRNSRMV CCCCEEECCCCCCEE	18.40	22006019
244	Phosphorylation	RNSRMVCSPVTVRIA CCCCEEEECEEEEEC	15.82	26824392
247	Phosphorylation	RMVCSPVTVRIAPPD CEEEECEEEEECCCC	13.88	25159016
255	Phosphorylation	VRIAPPDSKLFRSSM EEECCCCCHHHHHHC	36.71	22802335
256	Ubiquitination	RIAPPDSKLFRSSMS EECCCCCHHHHHHCC	60.05	-
260	Phosphorylation	PDSKLFRSSMSEQIL CCCHHHHHHCCHHHH	24.06	22006019
261	Phosphorylation	DSKLFRSSMSEQILD CCHHHHHHCCHHHHH	23.28	22942356
263	Phosphorylation	KLFRSSMSEQILDTT HHHHHHCCHHHHHHH	28.44	22802335
269	Phosphorylation	MSEQILDTTLSSPSS CCHHHHHHHCCCCCC	26.62	22802335
270	Phosphorylation	SEQILDTTLSSPSSN CHHHHHHHCCCCCCC	25.06	30482847
273	Phosphorylation	ILDTTLSSPSSNAPD HHHHHCCCCCCCCCC	31.73	22802335
275	Phosphorylation	DTTLSSPSSNAPDPC HHHCCCCCCCCCCHH	37.87	22802335
276	Phosphorylation	TTLSSPSSNAPDPCA HHCCCCCCCCCCHHH	40.16	22802335
319	Phosphorylation	NKRRRHDSGGSGHSA CCCCCCCCCCCCCCC	38.64	26824392
322	Phosphorylation	RRHDSGGSGHSAFEP CCCCCCCCCCCCHHH	36.54	21082442
325	Phosphorylation	DSGGSGHSAFEPLVA CCCCCCCCCHHHHHH	37.87	21082442
345	Phosphorylation	AFVPKPGSLKRSLAS CCCCCCCCHHHHHHH	38.96	25159016
349	Phosphorylation	KPGSLKRSLASQSSD CCCCHHHHHHHCCCH	27.05	25159016
352	Phosphorylation	SLKRSLASQSSDDHL CHHHHHHHCCCHHHH	35.57	26824392
354	Phosphorylation	KRSLASQSSDDHLNK HHHHHHCCCHHHHHH	32.99	22802335
355	Phosphorylation	RSLASQSSDDHLNKR HHHHHCCCHHHHHHH	39.15	26824392
363	Phosphorylation	DDHLNKRSRTSSVSS HHHHHHHHHHHHHHH	41.33	22817900
365	Phosphorylation	HLNKRSRTSSVSSLA HHHHHHHHHHHHHHH	26.97	23527152
366	Phosphorylation	LNKRSRTSSVSSLAS HHHHHHHHHHHHHHH	27.86	21082442
367	Phosphorylation	NKRSRTSSVSSLASA HHHHHHHHHHHHHHH	25.96	25521595
369	Phosphorylation	RSRTSSVSSLASACT HHHHHHHHHHHHHHH	22.91	22942356
370	Phosphorylation	SRTSSVSSLASACTG HHHHHHHHHHHHHHC	26.29	25521595
373	Phosphorylation	SSVSSLASACTGGIP HHHHHHHHHHHCCCC	29.21	25293948
376	Phosphorylation	SSLASACTGGIPSSS HHHHHHHHCCCCCCH	37.85	25619855
381	Phosphorylation	ACTGGIPSSSRNAIT HHHCCCCCCHHHCHH	38.74	25619855
382	Phosphorylation	CTGGIPSSSRNAITS HHCCCCCCHHHCHHC	28.14	25619855
383	Phosphorylation	TGGIPSSSRNAITSS HCCCCCCHHHCHHCC	33.61	25619855
398	Phosphorylation	YSSTRGISQLWKRSG CCCHHCHHHHHHHHC	23.26	28725479
404	Phosphorylation	ISQLWKRSGPTSSPF HHHHHHHHCCCCCCC	45.45	25619855
407	Phosphorylation	LWKRSGPTSSPFSSP HHHHHCCCCCCCCCC	45.41	23375375
408	Phosphorylation	WKRSGPTSSPFSSPA HHHHCCCCCCCCCCC	38.86	23684622
409	Phosphorylation	KRSGPTSSPFSSPAS HHHCCCCCCCCCCCC	32.23	23527152
412	Phosphorylation	GPTSSPFSSPASSRS CCCCCCCCCCCCCCC	38.50	23684622
413	Phosphorylation	PTSSPFSSPASSRSQ CCCCCCCCCCCCCCC	25.51	22942356
416	Phosphorylation	SPFSSPASSRSQTPE CCCCCCCCCCCCCCC	29.66	23375375
417	Phosphorylation	PFSSPASSRSQTPER CCCCCCCCCCCCCCC	37.75	23375375
419	Phosphorylation	SSPASSRSQTPERPA CCCCCCCCCCCCCCC	40.11	21659605
421	Phosphorylation	PASSRSQTPERPAKK CCCCCCCCCCCCCCC	28.50	25159016
429	Phosphorylation	PERPAKKTREEEPCQ CCCCCCCCCCCCCCC	42.48	25619855
438	Phosphorylation	EEEPCQQSSSSPPLV CCCCCCCCCCCCCCC	13.30	25619855
439	Phosphorylation	EEPCQQSSSSPPLVT CCCCCCCCCCCCCCC	30.42	25619855
440	Phosphorylation	EPCQQSSSSPPLVTD CCCCCCCCCCCCCCC	52.70	25619855
441	Phosphorylation	PCQQSSSSPPLVTDK CCCCCCCCCCCCCCC	32.27	25521595
446	Phosphorylation	SSSPPLVTDKESPGE CCCCCCCCCCCCCCC	49.38	25619855
450	Phosphorylation	PLVTDKESPGEKVTD CCCCCCCCCCCEEEC	43.90	25619855
468	Phosphorylation	GKQQSSWTSPPTPGS CCCCCCCCCCCCCCC	33.05	28066266
469	Phosphorylation	KQQSSWTSPPTPGSS CCCCCCCCCCCCCCC	23.71	25619855
472	Phosphorylation	SSWTSPPTPGSSGQR CCCCCCCCCCCCCHH	43.60	25619855
475	Phosphorylation	TSPPTPGSSGQRKRK CCCCCCCCCCHHHHE	32.28	28066266
476	Phosphorylation	SPPTPGSSGQRKRKI CCCCCCCCCHHHHEE	44.88	28066266
488	Phosphorylation	RKIQLLPSRRGDQLT HEEEECCCCCCCCCC	34.28	22802335
518	Phosphorylation	LDMERKASLQWFNKV HCHHHHHHHHHHHHH	24.91	28833060
568	Phosphorylation	PASLPAPSSNPLLES CCCCCCCCCCHHHHH	44.87	23140645
569	Phosphorylation	ASLPAPSSNPLLESL CCCCCCCCCHHHHHH	41.21	23140645
582	Phosphorylation	SLKKMQESPAPSSSE HHHHHHCCCCCCCCC	14.96	29472430
586	Phosphorylation	MQESPAPSSSEPAEA HHCCCCCCCCCCHHH	48.91	25159016
587	Phosphorylation	QESPAPSSSEPAEAA HCCCCCCCCCCHHHH	37.35	25159016
588	Phosphorylation	ESPAPSSSEPAEAAT CCCCCCCCCCHHHHC	52.52	25159016
595	Phosphorylation	SEPAEAATVAAPSPP CCCHHHHCCCCCCCC	20.09	28066266
600	Phosphorylation	AATVAAPSPPKTPSL HHCCCCCCCCCCHHH	49.46	28066266
604	Phosphorylation	AAPSPPKTPSLLAPL CCCCCCCCHHHHHHH	24.71	26643407
606	Phosphorylation	PSPPKTPSLLAPLVS CCCCCCHHHHHHHHC	41.04	26643407
613	Phosphorylation	SLLAPLVSPLAGPLA HHHHHHHCCCCCCCC	23.14	25266776
621	Phosphorylation	PLAGPLASTSSDSKP CCCCCCCCCCCCCCC	36.18	20469934
622	Phosphorylation	LAGPLASTSSDSKPA CCCCCCCCCCCCCCH	27.00	20469934
623	Phosphorylation	AGPLASTSSDSKPAA CCCCCCCCCCCCCHH	29.65	20469934
624	Phosphorylation	GPLASTSSDSKPAAT CCCCCCCCCCCCHHH	46.09	20469934
626	Phosphorylation	LASTSSDSKPAATFL CCCCCCCCCCHHHHH	42.35	20469934
639	Phosphorylation	FLGLASASSITPLTD HHHHHCCCCCCCCCC	21.56	28066266
640	Phosphorylation	LGLASASSITPLTDS HHHHCCCCCCCCCCC	30.14	28066266
642	Phosphorylation	LASASSITPLTDSKS HHCCCCCCCCCCCCC	17.75	28066266
645	Phosphorylation	ASSITPLTDSKSSGV CCCCCCCCCCCCCCC	39.16	28066266
647	Phosphorylation	SITPLTDSKSSGVSQ CCCCCCCCCCCCCCH	29.24	28066266
664	Phosphorylation	QSVSTPASTASSPTP HHCCCCCCCCCCCCC	26.21	26643407
665	Phosphorylation	SVSTPASTASSPTPK HCCCCCCCCCCCCCC	32.44	26643407
667	Phosphorylation	STPASTASSPTPKPS CCCCCCCCCCCCCCC	36.62	26643407
668	Phosphorylation	TPASTASSPTPKPSM CCCCCCCCCCCCCCH	30.26	26643407
670	Phosphorylation	ASTASSPTPKPSMLF CCCCCCCCCCCCHHC	45.98	26643407
708	Phosphorylation	FKPIFPATPKSESDS CCCCCCCCCCCCCCC	31.33	28418008

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PO121_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PO121_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PO121_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PO121_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-355, AND MASSSPECTROMETRY.
PubMed: 19367708

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319; SER-322; SER-325AND SER-409, AND MASS SPECTROMETRY.
PubMed: 17242355