CASP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CASP1_MOUSE
• UniProt AC: P29452
• Protein Name: Caspase-1
• Gene Name: Casp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 402
• Subcellular Localization: Cytoplasm.
• Protein Description: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. [PubMed: 28314590]
• Protein Sequence: MADKILRAKRKQFINSVSIGTINGLLDELLEKRVLNQEEMDKIKLANITAMDKARDLCDHVSKKGPQASQIFITYICNEDCYLAGILELQSAPSAETFVATEDSKGGHPSSSETKEEQNKEDGTFPGLTGTLKFCPLEKAQKLWKENPSEIYPIMNTTTRTRLALIICNTEFQHLSPRVGAQVDLREMKLLLEDLGYTVKVKENLTALEMVKEVKEFAACPEHKTSDSTFLVFMSHGIQEGICGTTYSNEVSDILKVDTIFQMMNTLKCPSLKDKPKVIIIQACRGEKQGVVLLKDSVRDSEEDFLTDAIFEDDGIKKAHIEKDFIAFCSSTPDNVSWRHPVRGSLFIESLIKHMKEYAWSCDLEDIFRKVRFSFEQPEFRLQMPTADRVTLTKRFYLFPGH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
120	Acetylation	ETKEEQNKEDGTFPG HCHHHHHCCCCCCCC	57.80	8275647
284	Glutathionylation	KVIIIQACRGEKQGV EEEEEEECCCCCCEE	3.09	24333276
297	Phosphorylation	GVVLLKDSVRDSEED EEEEEECCCCCCCCH	19.91	30635358
301	Phosphorylation	LKDSVRDSEEDFLTD EECCCCCCCCHHHHH	32.11	22817900
307	Phosphorylation	DSEEDFLTDAIFEDD CCCCHHHHHHHHCCC	24.31	30635358
343	Methylation	VSWRHPVRGSLFIES CCCCCCCCCHHHHHH	33.17	24129315

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CASP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CASP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CASP1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TNAP3_MOUSE	Tnfaip3	physical	25607459
IL1B_MOUSE	Il1b	physical	25607459

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.