IL1B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IL1B_MOUSE
• UniProt AC: P10749
• Protein Name: Interleukin-1 beta
• Gene Name: Il1b
• Organism: Mus musculus (Mouse).
• Sequence Length: 269
• Subcellular Localization: Cytoplasm, cytosol . Lysosome . Secreted, exosome . Cytoplasmic vesicle, autophagosome . Secreted . The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflam
• Protein Description: Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells..
• Protein Sequence: MATVPELNCEMPPFDSDENDLFFEVDGPQKMKGCFQTFDLGCPDESIQLQISQQHINKSFRQAVSLIVAVEKLWQLPVSFPWTFQDEDMSTFFSFIFEEEPILCDSWDDDDNLLVCDVPIRQLHYRLRDEQQKSLVLSDPYELKALHLNGQNINQQVIFSMSFVQGEPSNDKIPVALGLKGKNLYLSCVMKDGTPTLQLESVDPKQYPKKKMEKRFVFNKIEVKSKVEFESAEFPNWYISTSQAEHKPVFLGNNSGQDIIDFTMESVSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MATVPELNCE -----CCCCCCCCCC	34.98	30635358
16	Phosphorylation	CEMPPFDSDENDLFF CCCCCCCCCCCCEEE	47.40	30635358
134	Phosphorylation	LRDEQQKSLVLSDPY CCHHHHHCCCCCCHH	21.26	22942356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IL1B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IL1B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IL1B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ILRL1_MOUSE	Il1rl1	physical	17623648
TNAP3_MOUSE	Tnfaip3	physical	25607459
CASP1_MOUSE	Casp1	physical	25607459
CASP8_MOUSE	Casp8	physical	25607459
RIPK1_MOUSE	Ripk1	physical	25607459
RIPK3_MOUSE	Ripk3	physical	25607459

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.