dbPTM

ILRL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ILRL1_MOUSE
UniProt AC	P14719
Protein Name	Interleukin-1 receptor-like 1
Gene Name	Il1rl1
Organism	Mus musculus (Mouse).
Sequence Length	567
Subcellular Localization	Cell membrane Single-pass type I membrane protein. Isoform B: Secreted.
Protein Description	Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. [PubMed: 18450470]
Protein Sequence	MIDRQRMGLWALAILTLPMYLTVTEGSKSSWGLENEALIVRCPQRGRSTYPVEWYYSDTNESIPTQKRNRIFVSRDRLKFLPARVEDSGIYACVIRSPNLNKTGYLNVTIHKKPPSCNIPDYLMYSTVRGSDKNFKITCPTIDLYNWTAPVQWFKNCKALQEPRFRAHRSYLFIDNVTHDDEGDYTCQFTHAENGTNYIVTATRSFTVEEKGFSMFPVITNPPYNHTMEVEIGKPASIACSACFGKGSHFLADVLWQINKTVVGNFGEARIQEEEGRNESSSNDMDCLTSVLRITGVTEKDLSLEYDCLALNLHGMIRHTIRLRRKQPIDHRSIYYIVAGCSLLLMFINVLVIVLKVFWIEVALFWRDIVTPYKTRNDGKLYDAYIIYPRVFRGSAAGTHSVEYFVHHTLPDVLENKCGYKLCIYGRDLLPGQDAATVVESSIQNSRRQVFVLAPHMMHSKEFAYEQEIALHSALIQNNSKVILIEMEPLGEASRLQVGDLQDSLQHLVKIQGTIKWREDHVADKQSLSSKFWKHVRYQMPVPERASKTASVAAPLSGKACLDLKHF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	N-linked_Glycosylation	EWYYSDTNESIPTQK EEEECCCCCCCCCCC	46.11	-
101	N-linked_Glycosylation	VIRSPNLNKTGYLNV EEECCCCCCCEEEEE	46.62	-
102	Acetylation	IRSPNLNKTGYLNVT EECCCCCCCEEEEEE	46.63	7712647
107	N-linked_Glycosylation	LNKTGYLNVTIHKKP CCCCEEEEEEEECCC	22.02	-
146	N-linked_Glycosylation	CPTIDLYNWTAPVQW ECEEEECCCCCCCHH	36.60	-
176	N-linked_Glycosylation	RSYLFIDNVTHDDEG CEEEEEECCCCCCCC	35.45	-
194	N-linked_Glycosylation	CQFTHAENGTNYIVT EEEEECCCCCEEEEE	64.47	-
220	Phosphorylation	FSMFPVITNPPYNHT EEEEEEECCCCCCCE	41.74	-
224	Phosphorylation	PVITNPPYNHTMEVE EEECCCCCCCEEEEE	22.34	-
225	N-linked_Glycosylation	VITNPPYNHTMEVEI EECCCCCCCEEEEEE	29.90	-
259	N-linked_Glycosylation	ADVLWQINKTVVGNF HHHHHHCCCCEECCC	20.88	-
278	N-linked_Glycosylation	IQEEEGRNESSSNDM CCHHCCCCCCCCCHH	65.44	-
320	Phosphorylation	LHGMIRHTIRLRRKQ HHHHHHHHHHCCCCC	9.65	21454597
326	Ubiquitination	HTIRLRRKQPIDHRS HHHHCCCCCCCCHHH	54.73	-
442	Phosphorylation	AATVVESSIQNSRRQ HHHHHHHHHHHCCCE	18.06	22660580
446	Phosphorylation	VESSIQNSRRQVFVL HHHHHHHCCCEEEEE	16.68	-
551	Phosphorylation	ERASKTASVAAPLSG CHHCCCCCEECCCCC	19.95	29514104
557	Phosphorylation	ASVAAPLSGKACLDL CCEECCCCCCCCCCC	36.87	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
442	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
442	S	Phosphorylation	Kinase	GSK3B	Q9WV60	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ILRL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ILRL1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ILRL1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ILRL1_MOUSE

Related Literatures of Post-Translational Modification