LOXH1_MOUSE - dbPTM
LOXH1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LOXH1_MOUSE
UniProt AC C8YR32
Protein Name Lipoxygenase homology domain-containing protein 1
Gene Name Loxhd1
Organism Mus musculus (Mouse).
Sequence Length 2068
Subcellular Localization Cell projection, stereocilium .
Protein Description Required for normal function of hair cells in the inner ear..
Protein Sequence MMAQKKKRRKKDIDFLGLYEEELLNYDSEDGEDELEHEYYKAKVYEVVTATGDVRGAGTDANVFITLFGENGLSPKLHLTSKSESAFEKANVDVFRVRTNNVGLIYKIRIEHDNTGLNASWYLDRVIVTDMKRPHLRYYFNCNNWLSKVEGDRQWCRDLLASFDPMDMPRGNKYEIKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEKDNFEKGAEDKFTLDAPDLGQLMKINVGHNNKGGSAGWFLSKIIIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILVGGAETTAITYIVTVFTGDIRGAGTKSKIYLVMYGARGNKNSGKIFLEGGVFDRGRTDIFHIDLAVLLSPLSRVSIGHGNIGVNRGWYCEKVVILCPFTGIQQTFPCSNWLDEKKADGLIERQLYEMVSLRKKRLKKYPWSLWVWTTDLKKAGTNSPIFIQIYGKKGRTDEILLNPNNKWFKPGIIEKFRMELPDLGRFYKIRAWHDRQNPGSGWHLEKMTLMNTINKDKYNFNCNRWLDANEDDNEIVREMTAEGPTVRRIMGMARYRVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIESVTMRKVRRVRVRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDGQLVRELLPSDSNATLKNFRYHISVKTGDVSGASTDSRVYIKLYGEKSDTIKQVLLVSDNNLKDYFERGRVDEFTLETLNIGTINRLVIGHDSTGMHAGWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRLEVELYPSEVVEIQKLVHYEIEIWTGDVGGAGTTSRVFVQIYGEEGKTEVLFLSSRSKVFDRGSKDIFQTDTFTIYAIDLGALTKIRIRHDNTGNRPGWFLDRVDITDVNNETTYYFPCQRWLAVEEDDGQLSRELLPVDESYVLPSEDEEGGGQGDNNPLDNLALEQKDKSTTFSVTIKTGDKKNAGTDANVFITLFGTQDNNGMTLLKSSKTNSDKFERDSIEIFTVETLDLGDLWKVRIGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIVRDLFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIVIYGCDAVCTRQKFLCTNKREQKLFFERKSASRFIVELEDVGEIIEKIRIGHDNTGINPGWHCSHVDIRRLLPEKDGTETLTFPCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNVPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFEKGTADTFIIEAADLGVIYKIKLRHDNTKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRSSNCSSPADFWEIALSSKMADVDIDTVTGPMVDYVQDGPVIPYYVSVTTGKHKEAATDSRAFVLLIGEDDECTNRIWLDYPQGKRGFSCGSVEEFYVGGLDVGIIKKIELGHDGASPESCWLVEELCLAVPTQGTKYTLRCNCWLAKDRGDGVTSRVFDLLDAMVVNIGKKVLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEVQLDKKKARFEREQNDTFIMEILDIAPFTKMRIRIDGMGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQKKGKKTLVCEICAVIDGEEMMEWTSYTVSVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFSDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFRFQCDCWLSKSEGDRQTLRDFACANNEIRDELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLVENSSRQRAFRKGTTDTFEFDSIFLGDIASLCVGHLAREDRFIPKRELVWHVKTITITEMEYGNVYFFNCDCLIPLKRKRKYFKVFEVTKTTESFASKIQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYYSGWLVEKVEVTNTSTGVATIFSCGRWLDKSRGDGLTWRELFPSV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
313AcetylationDIRGAGTKSKIYLVM
CCCCCCCCCEEEEEE		49.1619846639
331AcetylationRGNKNSGKIFLEGGV
CCCCCCCCEEEECCC		30.0615620577
412PhosphorylationGLIERQLYEMVSLRK
CHHHHHHHHHHHHHH		8.1420116462
969PhosphorylationALEQKDKSTTFSVTI
EEEECCCCEEEEEEE		42.7022871156
973PhosphorylationKDKSTTFSVTIKTGD
CCCCEEEEEEEECCC		19.0922871156
1235PhosphorylationYDIFTEKYMKDGSLR
HHHHCHHHCCCCCHH		11.8121454597
1535PhosphorylationKDRGDGVTSRVFDLL
ECCCCCHHHHHHHHH		19.1528059163
1555PhosphorylationNIGKKVLYEMTVWTG
ECCCCEEEEEEEECC		13.4725777480
1558PhosphorylationKKVLYEMTVWTGDVV
CCEEEEEEEECCCEE		10.8425777480
1561PhosphorylationLYEMTVWTGDVVGGG
EEEEEEECCCEECCC		21.1125777480
1569PhosphorylationGDVVGGGTDSNIFMT
CCEECCCCCCCEEEE		39.2625777480
1571PhosphorylationVVGGGTDSNIFMTLY
EECCCCCCCEEEEEE		31.5025777480
1576PhosphorylationTDSNIFMTLYGINGS
CCCCEEEEEEECCCC		13.1825777480
1578PhosphorylationSNIFMTLYGINGSTE
CCEEEEEEECCCCCC		13.5425777480
1583PhosphorylationTLYGINGSTEEVQLD
EEEECCCCCCEEECH		28.3225777480
1584PhosphorylationLYGINGSTEEVQLDK
EEECCCCCCEEECHH		37.2525777480
1642PhosphorylationILLKNMNTGDLTMFY
HHHHCCCCCCEEEEE		22.7028576409
1719PhosphorylationGTLALKQSANWNKFE
CCEEEECCCCCCCCC		23.2227180971
1910PhosphorylationEMEYGNVYFFNCDCL
EEEECCEEEEECCEE		13.3722871156
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LOXH1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LOXH1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LOXH1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of LOXH1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LOXH1_MOUSE

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Related Literatures of Post-Translational Modification

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