MYH14_MOUSE - dbPTM
MYH14_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MYH14_MOUSE
UniProt AC Q6URW6
Protein Name Myosin-14
Gene Name Myh14
Organism Mus musculus (Mouse).
Sequence Length 2000
Subcellular Localization
Protein Description Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping..
Protein Sequence MAAVTMSVSGRKVASRPGPVPEAAQSFLYAPRTPNVGGPGGPQVEWTARRMVWVPSELHGFEAAALRDEGEEEAEVELAESGRRLRLPRDQIQRMNPPKFSKAEDMAELTCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPHVYAVTEGAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSPKGRKEPGVPASVSTMSYGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDIAGYIVGANIETYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLKADLLLEPCSHYRFLTNGPSSSPGQERELFQETLESLRVLGLLPEEITAMLRTVSAVLQFGNIVLKKERNTDQATMPDNTAAQKLCRLLGLGVTDFSRALLTPRIKVGRDYVQKAQTKEQADFALEALAKATYERLFRWLVLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTMFVLEQEEYQREGIPWTFLDFGLDLQPCIDLIERPANPPGLLALLDEECWFPKATDKSFVEKVAQEQGSHPKFQRPRNLRDQADFSVLHYAGKVDYKASEWLMKNMDPLNDNVAALLHQSTDRLTAEIWKDVEGIVGLEQVSSLGDGPPGGRPRRGMFRTVGQLYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGKLEPRLVLDQLRCNGVLEGIRICRQGFPNRILFQEFRQRYEILTPNAIPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARGYLARRAFQRRQQQQSALRVMQRNCAAYLKLRNWQWWRLFIKVKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERTRLAEQLRAEAELCSEAEETRARLAARKQELELVVTELEARVGEEEECSRQLQSEKKRLQQHIQELESHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERRLLEERLAEFSSQAAEEEEKVKSLNKLRLKYEATISDMEDRLKKEEKGRQELEKLKRRLDGESSELQEQMVEQKQRAEELLAQLGRKEDELQAALLRAEEEGGARAQLLKSLREAQAGLAEAQEDLEAERVARAKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKALEEESRAHEVSMQELRQRHSQALVEMAEQLEQARRGKGVWEKTRLSLEAEVSELKAELSSLQTSRQEGEQKRRRLESQLQEVQGRSSDSERARSEAAEKLQRAQAELESVSTALSEAESKAIRLGKELSSAESQLHDTQELLQEETRAKLALGSRVRALEAEAAGLREQMEEEVVARERAGRELQSTQAQLSEWRRRQEEEAAVLEAGEEARRRAAREAETLTQRLAEKTEAVERLERARRRLQQELDDATVDLGQQKQLLSTLEKKQRKFDQLLAEEKAAVLRAVEDRERIEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKNVHELERARKAAEQAASDLRTQVTELEDELTAAEDAKLRLEVTVQALKAQHERDLQGRDDAGEERRRQLAKQLRDAEVERDEERKQRALAMAARKKLELELEELKAQTSAAGQGKEEAVKQLKKMQVQMKELWREVEETRSSRDEMFTLSRENEKKLKGLEAEVLRLQEELAASDRARRQAQQDRDEMAEEVASGNLSKAATLEEKRQLEGRLSQLEEELEEEQNNSELLKDHYRKLVLQVESLTTELSAERSFSAKAESGRQQLERQIQELRARLGEEDAGARARQKMLIAALESKLAQAEEQLEQESRERILSGKLVRRAEKRLKEVVLQVDEERRVADQVRDQLEKSNLRLKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEEAEGAEPGSAPGQEPEAPPPATPQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAAVTMSVS
------CCCEEEECC		23.19-
5Phosphorylation---MAAVTMSVSGRK
---CCCEEEECCCCC		10.0520531401
7Phosphorylation-MAAVTMSVSGRKVA
-CCCEEEECCCCCCC		12.0820531401
33PhosphorylationSFLYAPRTPNVGGPG
HHHHCCCCCCCCCCC		20.3922817900
56PhosphorylationRRMVWVPSELHGFEA
CEEEEECHHHCCCCH		43.07-
99UbiquitinationIQRMNPPKFSKAEDM
HHHCCCCCCCCHHHH		64.62-
99AcetylationIQRMNPPKFSKAEDM
HHHCCCCCCCCHHHH		64.6223806337
101PhosphorylationRMNPPKFSKAEDMAE
HCCCCCCCCHHHHHH		36.7629550500
158PhosphorylationTEAIVEMYRGKKRHE
HHHHHHHHCCCCCCC		11.6028059163
201PhosphorylationGESGAGKTENTKKVI
CCCCCCCCCCHHHHH		33.2817203969
204PhosphorylationGAGKTENTKKVIQYL
CCCCCCCHHHHHHHH		26.4717203969
210PhosphorylationNTKKVIQYLAHVASS
CHHHHHHHHHHHHCC		8.50-
248UbiquitinationQLLQANPILEAFGNA
HHHHHCHHHHHHCCC		5.6427667366
256UbiquitinationLEAFGNAKTVKNDNS
HHHHCCCEECCCCCC		58.8327667366
264PhosphorylationTVKNDNSSRFGKFIR
ECCCCCCCCCCEEEE		37.5726824392
268AcetylationDNSSRFGKFIRINFD
CCCCCCCEEEEEEEE		34.60133169
293PhosphorylationETYLLEKSRAIRQAK
HHHHHHHHHHHHHHC		19.9818779572
430PhosphorylationRIKVGRDYVQKAQTK
CHHCCHHHHHHHCCH		11.9225195567
433UbiquitinationVGRDYVQKAQTKEQA
CCHHHHHHHCCHHHH		32.20-
437AcetylationYVQKAQTKEQADFAL
HHHHHCCHHHHHHHH		35.4323806337
437UbiquitinationYVQKAQTKEQADFAL
HHHHHCCHHHHHHHH		35.4322790023
437SuccinylationYVQKAQTKEQADFAL
HHHHHCCHHHHHHHH		35.4323806337
437UbiquitinationYVQKAQTKEQADFAL
HHHHHCCHHHHHHHH		35.43-
570UbiquitinationWFPKATDKSFVEKVA
CCCCCCCHHHHHHHH		41.25-
571PhosphorylationFPKATDKSFVEKVAQ
CCCCCCHHHHHHHHH		37.0229176673
582PhosphorylationKVAQEQGSHPKFQRP
HHHHHCCCCCCCCCC		35.9927841257
679UbiquitinationRTVGQLYKESLSRLM
HHHHHHHHHHHHHHH		49.7922790023
679UbiquitinationRTVGQLYKESLSRLM
HHHHHHHHHHHHHHH		49.7922790023
688PhosphorylationSLSRLMATLSNTNPS
HHHHHHHHHHCCCCC		19.4322817900
690PhosphorylationSRLMATLSNTNPSFV
HHHHHHHHCCCCCCE		36.9322817900
753PhosphorylationRQRYEILTPNAIPKG
HHHHCCCCCCCCCCC		21.84-
835PhosphorylationQRRQQQQSALRVMQR
HHHHHHHHHHHHHHH		25.5718779572
876UbiquitinationTRQDEVLQARAQELQ
CCHHHHHHHHHHHHH		33.7027667366
884UbiquitinationARAQELQKVQELQQQ
HHHHHHHHHHHHHHH		59.5222790023
884UbiquitinationARAQELQKVQELQQQ
HHHHHHHHHHHHHHH		59.5222790023
917UbiquitinationRTRLAEQLRAEAELC
HHHHHHHHHHHHHHH		4.1627667366
925PhosphorylationRAEAELCSEAEETRA
HHHHHHHHHHHHHHH		53.0922817900
986UbiquitinationHLEAEEGARQKLQLE
HHHHHHHHHHHHHHH		17.6327667366
994UbiquitinationRQKLQLEKVTTEAKM
HHHHHHHHCCCHHHH		54.1727667366
994AcetylationRQKLQLEKVTTEAKM
HHHHHHHHCCCHHHH		54.1723806337
994SuccinylationRQKLQLEKVTTEAKM
HHHHHHHHCCCHHHH		54.1723806337
1027UbiquitinationKERRLLEERLAEFSS
HHHHHHHHHHHHHHH		53.6227667366
1045PhosphorylationEEEEKVKSLNKLRLK
HHHHHHHHHHHHHHH		39.91-
1179PhosphorylationLRGELEDTLDSTNAQ
HHHHHHHHHCCCHHH		24.08-
1198PhosphorylationSKREQEVTELKKALE
HHHHHHHHHHHHHHH		34.54-
1249PhosphorylationVWEKTRLSLEAEVSE
HHHHHHHHHHHHHHH		22.3722817900
1255PhosphorylationLSLEAEVSELKAELS
HHHHHHHHHHHHHHH		28.81-
1262PhosphorylationSELKAELSSLQTSRQ
HHHHHHHHHHHHHHH		22.10-
1263PhosphorylationELKAELSSLQTSRQE
HHHHHHHHHHHHHHH		36.80-
1280PhosphorylationQKRRRLESQLQEVQG
HHHHHHHHHHHHHHC		40.5622817900
1389PhosphorylationRAGRELQSTQAQLSE
HHHHHHHHHHHHHHH		34.8028978645
1390PhosphorylationAGRELQSTQAQLSEW
HHHHHHHHHHHHHHH		18.2428978645
1395PhosphorylationQSTQAQLSEWRRRQE
HHHHHHHHHHHHHHH		24.0426824392
1424PhosphorylationRAAREAETLTQRLAE
HHHHHHHHHHHHHHH		42.0022802335
1458 (in isoform 2)Phosphorylation-24.3319144319
1466PhosphorylationQQKQLLSTLEKKQRK
HHHHHHHHHHHHHHH		38.6219144319
1508PhosphorylationEREARALSLTRALEE
HHHHHHHHHHHHHHH		27.0623737553
1510PhosphorylationEARALSLTRALEEEQ
HHHHHHHHHHHHHHH		15.5422324799
1539PhosphorylationAELEALLSSKDDVGK
HHHHHHHCCCCCCCC		35.8725338131
1540PhosphorylationELEALLSSKDDVGKN
HHHHHHCCCCCCCCC		39.8219854140
1688PhosphorylationEVEETRSSRDEMFTL
HHHHHHCCHHHHHCC		40.2222942356
1696PhosphorylationRDEMFTLSRENEKKL
HHHHHCCCHHHHHHH		34.1922942356
1740PhosphorylationEMAEEVASGNLSKAA
HHHHHHHHCCHHHCC		33.1326643407
1744PhosphorylationEVASGNLSKAATLEE
HHHHCCHHHCCCHHH		25.0126643407
1748PhosphorylationGNLSKAATLEEKRQL
CCHHHCCCHHHHHHH		39.2926643407
1861PhosphorylationESRERILSGKLVRRA
HHHHHHHHHHHHHHH		31.3526026062
1895UbiquitinationQVRDQLEKSNLRLKQ
HHHHHHHHHHHHHHH		53.9222790023
1895UbiquitinationQVRDQLEKSNLRLKQ
HHHHHHHHHHHHHHH		53.9222790023
1934PhosphorylationELEDVTESAESMNRE
HHHHHHHHHHHHHHH		28.1528973931
1957PhosphorylationRRGPLTFTTRTVRQV
HCCCCCCCCCHHHHH		15.33-
1958PhosphorylationRGPLTFTTRTVRQVF
CCCCCCCCCHHHHHH		21.8322817900
1960PhosphorylationPLTFTTRTVRQVFRL
CCCCCCCHHHHHHCC		20.25-
1973PhosphorylationRLEEGVASDEEEAEG
CCHHCCCCCHHHHCC		43.0525521595
1985PhosphorylationAEGAEPGSAPGQEPE
HCCCCCCCCCCCCCC		41.8425293948
1998PhosphorylationPEAPPPATPQ-----
CCCCCCCCCC-----		28.1718056256
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MYH14_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MYH14_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MYH14_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MYH14_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MYH14_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1466, AND MASSSPECTROMETRY.

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