ERF_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ERF_MOUSE
• UniProt AC: P70459
• Protein Name: ETS domain-containing transcription factor ERF
• Gene Name: Erf
• Organism: Mus musculus (Mouse).
• Sequence Length: 551
• Subcellular Localization: Nucleus.
• Protein Description: Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation (By similarity). Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment. May be important for regulating trophoblast stem cell differentiation..
• Protein Sequence: MKTPADTGFAFPDWAYKPESSPGSRQIQLWHFILELLRKEEYQGVIAWQGDYGEFVIKDPDEVARLWGVRKCKPQMNYDKLSRALRYYYNKRILHKTKGKRFTYKFNFNKLVLVNYPFIDMGLAGGAVPQSAPPVPSGGSHFRFPPSTPSEVLSPTEDPRSPPACSSSSSSLFSAVVARRLGRGSVSDCSDGTSELEEPLGEDPRARPPGPPELGAFRGPPLARLPHDPGVFRVYPRPRGGPEPLSPFPVSPLAGPGSLLPPQLSPALPMTPTHLAYTPSPTLSPMYPSGGGGPSGSGGGSHFSFSPEDMKRYLQAHTQSVYNYHLSPRAFLHYPGLVVPQPQRPDKCPLPPMAPETPPVPSSASSSSSSSSSPFKFKLQPPPLGRRQRAAGEKAPGGTDKSSGGSGSGGLAEGAGAVAPPPPPPQIKVEPISEGESEEVEVTDISDEDEEDGEVFKTPRAPPAPPKPEPGEAPGVAQCMPLKLRFKRRWSEDCRLEGGGCLSGGPEDEGEDKKVRGDVGPGESGGPLTPRRVSSDLQHATAQLSLEHRDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MKTPADTGFA -----CCCCCCCCCC	23.55	27087446
7	Phosphorylation	-MKTPADTGFAFPDW -CCCCCCCCCCCCCC	35.98	25619855
16	Phosphorylation	FAFPDWAYKPESSPG CCCCCCCCCCCCCCC	23.87	25619855
20	Phosphorylation	DWAYKPESSPGSRQI CCCCCCCCCCCHHHH	50.81	23684622
21	Phosphorylation	WAYKPESSPGSRQIQ CCCCCCCCCCHHHHH	31.45	27087446
24	Phosphorylation	KPESSPGSRQIQLWH CCCCCCCHHHHHHHH	25.13	22942356
131	Phosphorylation	AGGAVPQSAPPVPSG CCCCCCCCCCCCCCC	36.35	26824392
137	Phosphorylation	QSAPPVPSGGSHFRF CCCCCCCCCCCCCCC	56.89	26160508
147	Phosphorylation	SHFRFPPSTPSEVLS CCCCCCCCCHHHCCC	53.86	25293948
148	Phosphorylation	HFRFPPSTPSEVLSP CCCCCCCCHHHCCCC	36.29	25293948
150	Phosphorylation	RFPPSTPSEVLSPTE CCCCCCHHHCCCCCC	40.19	25293948
154	Phosphorylation	STPSEVLSPTEDPRS CCHHHCCCCCCCCCC	34.64	25777480
156	Phosphorylation	PSEVLSPTEDPRSPP HHHCCCCCCCCCCCC	50.04	21183079
161	Phosphorylation	SPTEDPRSPPACSSS CCCCCCCCCCCCCCC	40.39	21149613
166	Phosphorylation	PRSPPACSSSSSSLF CCCCCCCCCCHHHHH	35.05	25293948
167	Phosphorylation	RSPPACSSSSSSLFS CCCCCCCCCHHHHHH	33.84	25293948
168	Phosphorylation	SPPACSSSSSSLFSA CCCCCCCCHHHHHHH	20.25	25293948
169	Phosphorylation	PPACSSSSSSLFSAV CCCCCCCHHHHHHHH	26.37	25293948
170	Phosphorylation	PACSSSSSSLFSAVV CCCCCCHHHHHHHHH	32.77	25293948
171	Phosphorylation	ACSSSSSSLFSAVVA CCCCCHHHHHHHHHH	35.07	25293948
174	Phosphorylation	SSSSSLFSAVVARRL CCHHHHHHHHHHHHH	26.00	25293948
185	Phosphorylation	ARRLGRGSVSDCSDG HHHHCCCCCCCCCCC	19.65	25521595
187	Phosphorylation	RLGRGSVSDCSDGTS HHCCCCCCCCCCCCC	34.30	25619855
190	Phosphorylation	RGSVSDCSDGTSELE CCCCCCCCCCCCCCC	44.03	25619855
193	Phosphorylation	VSDCSDGTSELEEPL CCCCCCCCCCCCCCC	24.82	25619855
194	Phosphorylation	SDCSDGTSELEEPLG CCCCCCCCCCCCCCC	45.79	25619855
246	Phosphorylation	RGGPEPLSPFPVSPL CCCCCCCCCCCCCCC	34.90	23608596
251	Phosphorylation	PLSPFPVSPLAGPGS CCCCCCCCCCCCCCC	17.90	23608596
318	Phosphorylation	KRYLQAHTQSVYNYH HHHHHHHHHHHHHHC	26.09	23984901
320	Phosphorylation	YLQAHTQSVYNYHLS HHHHHHHHHHHHCCC	27.94	23984901
322	Phosphorylation	QAHTQSVYNYHLSPR HHHHHHHHHHCCCCC	18.43	23984901
324	Phosphorylation	HTQSVYNYHLSPRAF HHHHHHHHCCCCCCC	6.10	23984901
327	Phosphorylation	SVYNYHLSPRAFLHY HHHHHCCCCCCCCCC	10.06	26824392
357	Phosphorylation	LPPMAPETPPVPSSA CCCCCCCCCCCCCCC	31.65	23608596
373	Phosphorylation	SSSSSSSSPFKFKLQ CCCCCCCCCCCEECC	35.98	23608596
433	Phosphorylation	QIKVEPISEGESEEV CCEEEECCCCCCCEE	50.71	21743459
437	Phosphorylation	EPISEGESEEVEVTD EECCCCCCCEEEEEE	50.33	21743459
443	Phosphorylation	ESEEVEVTDISDEDE CCCEEEEEECCCCCC	17.70	21149613
446	Phosphorylation	EVEVTDISDEDEEDG EEEEEECCCCCCCCC	37.44	30352176
491	Phosphorylation	LRFKRRWSEDCRLEG EEECCCCCCCCEECC	23.03	29899451
524	Phosphorylation	GDVGPGESGGPLTPR CCCCCCCCCCCCCCC	55.77	25619855
529	Phosphorylation	GESGGPLTPRRVSSD CCCCCCCCCCCCCHH	20.20	26824392
534	Phosphorylation	PLTPRRVSSDLQHAT CCCCCCCCHHHHHHH	19.14	26824392
535	Phosphorylation	LTPRRVSSDLQHATA CCCCCCCHHHHHHHH	39.21	25619855
541	Phosphorylation	SSDLQHATAQLSLEH CHHHHHHHHHHHHHC	16.89	25619855
545	Phosphorylation	QHATAQLSLEHRDS- HHHHHHHHHHCCCC-	21.45	26824392
551	Phosphorylation	LSLEHRDS------- HHHHCCCC-------	41.92	26370283

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
529	T	Phosphorylation	Kinase	ERK2	P63085	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
529	T	Phosphorylation	Phosphorylated by multiple kinases including MAPK1/ERK2 at THR-529.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ERF_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ERF_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.