dbPTM

LSM12_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LSM12_MOUSE
UniProt AC	Q9D0R8
Protein Name	Protein LSM12 homolog
Gene Name	Lsm12
Organism	Mus musculus (Mouse).
Sequence Length	195
Subcellular Localization
Protein Description
Protein Sequence	MAAPPGEYFSVGSQVSCRTCQEQRLQGEVVAFDYQSKMLALKCPSSSGKPNHADILLINLQYVSEVEIINDRTETPPPLASLNVSKLASKARTEKEEKLSQAYAISAGVSLEGQQLFQTIHKTIKDCKWQEKNIVVMEEVVITPPYQVENCKGKEGSALSHVRKIVEKHFRDVESQKILQRSQAQQPQKEAALSS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAPPGEYF ------CCCCCCCCE	28.77	-
34	Phosphorylation	GEVVAFDYQSKMLAL CEEEEEECCCCEEEE	14.29	29514104
73	Phosphorylation	VEIINDRTETPPPLA EEEECCCCCCCCCCH	47.26	25521595
75	Phosphorylation	IINDRTETPPPLASL EECCCCCCCCCCHHC	40.25	25521595
81	Phosphorylation	ETPPPLASLNVSKLA CCCCCCHHCCHHHHH	28.32	25619855
85	Phosphorylation	PLASLNVSKLASKAR CCHHCCHHHHHHHHC	22.37	25619855
86	Ubiquitination	LASLNVSKLASKART CHHCCHHHHHHHHCH	43.73	27667366
177	Malonylation	FRDVESQKILQRSQA CCCHHHHHHHHHHHC	55.45	26320211
182	Phosphorylation	SQKILQRSQAQQPQK HHHHHHHHHCCCHHH	19.53	30635358
194	Phosphorylation	PQKEAALSS------ HHHHHHHCC------	29.31	24453211
195	Phosphorylation	QKEAALSS------- HHHHHHCC-------	45.12	24453211

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LSM12_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LSM12_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LSM12_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of LSM12_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LSM12_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-73 AND THR-75, AND MASSSPECTROMETRY.	17242355 [Abstract]