dbPTM

TMX3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TMX3_MOUSE
UniProt AC	Q8BXZ1
Protein Name	Protein disulfide-isomerase TMX3
Gene Name	Tmx3
Organism	Mus musculus (Mouse).
Sequence Length	456
Subcellular Localization	Endoplasmic reticulum membrane Single-pass membrane protein.
Protein Description	Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase (By similarity)..
Protein Sequence	MANAVGRRSWAALRLCAAVILLDLAVCKGFVEDLNESFKDNRKDDIWLVDFYAPWCGHCKKLEPIWNEVGLEMKSIGSPVKVGKMDATSYSSIASEFGVRGYPTIKLLKGDLAYNYRGPRTKDDIIEFAHRVSGALIRPLPSQQMFDHVRKRHRVFFVYIGGESPLKEKYIDAASELIVYTYFFSASEDVVPEYVTLKEMPAVLVFKDDTYFVYDEYEDGDLSSWISRERFQNYLTMDGFLLYELGDTGKLVAIAVIDEKNTSLEHTRLKSIIQEVARDFRDHFHRDFQFGHMDGNDYINTLLMDELTVPTIVVLNTSNQQYFLLDRHIKDASDMVQFINSILDGTVPAQGGDSIFQRLKRIVFDAKSTIVSIFKSSPLMGCFLFGLPLGVISIMCYGIYTADTDGGYIEERYEVSKSEMENQEQIEESKEQESSSGGSLAPTVQEPKDVLEKKKD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	N-linked_Glycosylation	KGFVEDLNESFKDNR HHHHHHHHHHHHHCC	56.01	-
164	Phosphorylation	FVYIGGESPLKEKYI EEEECCCCCCHHHHH	38.52	21454597
261	N-linked_Glycosylation	IAVIDEKNTSLEHTR EEEEECCCCCCCHHH	32.62	-
316	N-linked_Glycosylation	VPTIVVLNTSNQQYF CCEEEEEECCCCCEE	29.83	-
418	Phosphorylation	ERYEVSKSEMENQEQ EEEEECHHHHHCHHH	34.37	25338131
434	Phosphorylation	EESKEQESSSGGSLA HHHHHHHCCCCCCCC	29.51	28066266
435	Phosphorylation	ESKEQESSSGGSLAP HHHHHHCCCCCCCCC	32.05	28066266
436	Phosphorylation	SKEQESSSGGSLAPT HHHHHCCCCCCCCCC	57.35	28066266
439	Phosphorylation	QESSSGGSLAPTVQE HHCCCCCCCCCCCCC	25.53	28066266
443	Phosphorylation	SGGSLAPTVQEPKDV CCCCCCCCCCCCHHH	29.25	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TMX3_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TMX3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TMX3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TMX3_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TMX3_MOUSE

Related Literatures of Post-Translational Modification