FIBA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FIBA_MOUSE
• UniProt AC: E9PV24
• Protein Name: Fibrinogen alpha chain
• Gene Name: Fga {ECO:0000312|MGI:MGI:1316726}
• Organism: Mus musculus (Mouse).
• Sequence Length: 789
• Subcellular Localization: Secreted .
• Protein Description: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. [PubMed: 7649481 In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization]
• Protein Sequence: MLSLRVTCLILSVASTVWTTDTEDKGEFLSEGGGVRGPRVVERHQSQCKDSDWPFCSDDDWNHKCPSGCRMKGLIDEANQDFTNRINKLKNSLFDFQRNNKDSNSLTRNIMEYLRGDFANANNFDNTYGQVSEDLRRRIEILRRKVIEKAQQIQALQSNVRAQLIDMKRLEVDIDIKIRSCKGSCSRAVNREINLQDYEGHQKQLQQVIAKELLPTKDRQYLPALKMSPVPDLVPGSFKSQLQEAPPEWKALTEMRQMRMELERPGKDGGSRGDSPGDSRGDSRGDFATRGPGSKAENPTNPGPGGSGYWRPGNSGSGSDGNRNPGTTGSDGTGDWGTGSPRPGSDSGNFRPANPNWGVFSEFGDSSSPATRKEYHTGKAVTSKGDKELLIGKEKVTSSGTSTTHRSCSKTITKTVTGPDGRREVVKEVITSDDGSDCGDATELDISHSFSGSLDELSERHPDLSGFFDNHFGLISPNFKEFGSKTHSDSDILTNIEDPSSHVPEFSSSSKTSTVKKQVTKTYKMADEAGSEAHREGETRNTKRGRARARPTRDCDDVLQTQTSGAQNGIFSIKPPGSSKVFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNDKGEGEFWLGNDYLHLLTLRGSVLRVELEDWAGKEAYAEYHFRVGSEAEGYALQVSSYRGTAGDALVQGSVEEGTEYTSHSNMQFSTFDRDADQWEENCAEVYGGGWWYNSCQAANLNGIYYPGGTYDPRNNSPYEIENGVVWVPFRGADYSLRAVRMKIRPLVGQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	RVVERHQSQCKDSDW HHHHHCHHHCCCCCC		22817900
72	Ubiquitination	CPSGCRMKGLIDEAN CCCCCCCCHHHHHHC		22790023
90	Ubiquitination	TNRINKLKNSLFDFQ HHHHHHHHHHHHHHH		22790023
92	Phosphorylation	RINKLKNSLFDFQRN HHHHHHHHHHHHHHC		22817900
103	Phosphorylation	FQRNNKDSNSLTRNI HHHCCCCCCHHHHHH		23737553
105	Phosphorylation	RNNKDSNSLTRNIME HCCCCCCHHHHHHHH		23737553
203	Ubiquitination	QDYEGHQKQLQQVIA HHHCHHHHHHHHHHH		22790023
211	Ubiquitination	QLQQVIAKELLPTKD HHHHHHHHHHCCCCC		22790023
217	Ubiquitination	AKELLPTKDRQYLPA HHHHCCCCCHHHCCC		22790023
250	Ubiquitination	QEAPPEWKALTEMRQ HHCCHHHHHHHHHHH		22790023
271	Phosphorylation	RPGKDGGSRGDSPGD CCCCCCCCCCCCCCC		23140645
275	Phosphorylation	DGGSRGDSPGDSRGD CCCCCCCCCCCCCCC		23140645
279	Phosphorylation	RGDSPGDSRGDSRGD CCCCCCCCCCCCCCC		23375375
283	Phosphorylation	PGDSRGDSRGDFATR CCCCCCCCCCCCCCC		27742792
295	Ubiquitination	ATRGPGSKAENPTNP CCCCCCCCCCCCCCC		22790023
307	Phosphorylation	TNPGPGGSGYWRPGN CCCCCCCCCCCCCCC		27742792
327	Phosphorylation	DGNRNPGTTGSDGTG CCCCCCCCCCCCCCC		21743459
328	Phosphorylation	GNRNPGTTGSDGTGD CCCCCCCCCCCCCCC		21743459
330	Phosphorylation	RNPGTTGSDGTGDWG CCCCCCCCCCCCCCC		21743459
333	Phosphorylation	GTTGSDGTGDWGTGS CCCCCCCCCCCCCCC		21743459
338	Phosphorylation	DGTGDWGTGSPRPGS CCCCCCCCCCCCCCC		20469934
387	Acetylation	AVTSKGDKELLIGKE EECCCCCCEEEEECE		23954790
387	Ubiquitination	AVTSKGDKELLIGKE EECCCCCCEEEEECE		22790023
393	Ubiquitination	DKELLIGKEKVTSSG CCEEEEECEEECCCC		22790023
397	Phosphorylation	LIGKEKVTSSGTSTT EEECEEECCCCCCCC		20469934
398	Phosphorylation	IGKEKVTSSGTSTTH EECEEECCCCCCCCC		20469934
399	Phosphorylation	GKEKVTSSGTSTTHR ECEEECCCCCCCCCC		24719451
401	Phosphorylation	EKVTSSGTSTTHRSC EEECCCCCCCCCCCC		20469934
402	Phosphorylation	KVTSSGTSTTHRSCS EECCCCCCCCCCCCC		20469934
414	Ubiquitination	SCSKTITKTVTGPDG CCCCEEEEEEECCCC		22790023
432	Phosphorylation	VVKEVITSDDGSDCG HEEEEECCCCCCCCC		29472430
436	Phosphorylation	VITSDDGSDCGDATE EECCCCCCCCCCCCE		29472430
442	Phosphorylation	GSDCGDATELDISHS CCCCCCCCEEECCCC		29472430
447	Phosphorylation	DATELDISHSFSGSL CCCEEECCCCCCCCH		22817900
449	Phosphorylation	TELDISHSFSGSLDE CEEECCCCCCCCHHH		30352176
451	Phosphorylation	LDISHSFSGSLDELS EECCCCCCCCHHHHH		30352176
453	Phosphorylation	ISHSFSGSLDELSER CCCCCCCCHHHHHHH		29472430
458	Phosphorylation	SGSLDELSERHPDLS CCCHHHHHHHCCCCC		29472430
476	Phosphorylation	DNHFGLISPNFKEFG CCCCCEECCCHHHHC		24719451
485	Ubiquitination	NFKEFGSKTHSDSDI CHHHHCCCCCCCCCC		22790023
490	Phosphorylation	GSKTHSDSDILTNIE CCCCCCCCCCCCCCC		24719451
494	Phosphorylation	HSDSDILTNIEDPSS CCCCCCCCCCCCCCC		23567750
500	Phosphorylation	LTNIEDPSSHVPEFS CCCCCCCCCCCCCCC		29472430
501	Phosphorylation	TNIEDPSSHVPEFSS CCCCCCCCCCCCCCC		29472430
504	Hydroxylation	EDPSSHVPEFSSSSK CCCCCCCCCCCCCCC		-
507	Phosphorylation	SSHVPEFSSSSKTST CCCCCCCCCCCCCHH		29472430
508	Phosphorylation	SHVPEFSSSSKTSTV CCCCCCCCCCCCHHH		29472430
509	Phosphorylation	HVPEFSSSSKTSTVK CCCCCCCCCCCHHHH		29472430
510	Phosphorylation	VPEFSSSSKTSTVKK CCCCCCCCCCHHHHH		29472430
531	Phosphorylation	KMADEAGSEAHREGE HHHHHHHHHHHHCCC		27742792
539	Phosphorylation	EAHREGETRNTKRGR HHHHCCCCCCCHHHC		20469934
609	N-linked_Glycosylation	MDGSLNFNRTWQDYK CCCCCCCCCCHHHHH		-
615	Phosphorylation	FNRTWQDYKRGFGSL CCCCHHHHHCCCCCC		28978645

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FIBA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FIBA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FIBA_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of FIBA_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.