DAAM1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DAAM1_MOUSE
• UniProt AC: Q8BPM0
• Protein Name: Disheveled-associated activator of morphogenesis 1
• Gene Name: Daam1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1077
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton, cilium basal body . Perinuclear.
• Protein Description: Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments (By similarity). Involved in building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly. [PubMed: 26526197]
• Protein Sequence: MAPRKRGGRGISFIFCCFRNNDHPEITYRLRNDSNFALQTMEPALPMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKKWQIYCSKKKDQEENKGATSWPEFYIDQLNSMAARKSLLALEKEEEEERSKTIESLKTALRTKPMRFVTRFIDLDGLSCILNFLKTMDYETSESRIHTSLIGCIKALMNNSQGRAHVLAHSESINVIAQSLSTENIKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQKYASERTRFQTLINDLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSATQMFELTRRRLTHSEAYPHFMSILHHCLQMPYKRSGNTVQYWLLLDRIIQQIVIQNDKGQDPDSTPLENFNIKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKETTEHKQVKQQVADLTAQLHELNRRAVCAAVPGGPSPGAPGGPFPSSGLGSLLPPPPPPLLSGGALPPPPPPLPPGGPPPPPGPPPLGGVLPPPGAPVSLTLKKKNIPQPTNALKSFNWSKLPENKLDGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQEFFVNNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSRALKQLLEVVLAFGNYMNKGQRGNAYGFKISSLNKIADTKSSIDKNITLLHYLITIVENKYPKVLNLSEELRDIPQAAKVNMTELDKEISTLRSGLKAVETELEYQKSQPPQPGDKFVSVVSQFITLASFSFSDVEDLLAEAKELFTKAVKHFGEEAGKIQPDEFFGIFDQFLQAVAEAKQENENMRKRKEEEERRARLEAQLKEQRERERKVRKAKESSEESGEFDDLVSALRSGEVFDKDLSKLKRNRKRISNQVTDSSRERPITKLNF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	NDHPEITYRLRNDSN CCCCCEEEEECCCCC	17.20	-
34	Phosphorylation	TYRLRNDSNFALQTM EEEECCCCCCEECCC	37.08	-
118	Phosphorylation	NSMAARKSLLALEKE HHHHHHHHHHHHHHH	24.06	25159016
139	Phosphorylation	KTIESLKTALRTKPM HHHHHHHHHHHHCCC	35.90	23882026
271	Phosphorylation	LDKSTGRYRDEVSLK HHHCCCCCCCHHHHH	24.62	-
652	Phosphorylation	LERTFSAYQRQQEFF HHHHHHHHHHHHHHC	11.75	-
674	Phosphorylation	EADAIDDTLSSKLKV HHHHCCHHHHHHCCE	25.45	26824392
676	Phosphorylation	DAIDDTLSSKLKVKE HHCCHHHHHHCCEEE	27.76	29899451
764	Phosphorylation	DRFLFEMSRINHYQQ HHHHHHHHHHHHHHH	23.86	-
777	Phosphorylation	QQRLQSLYFKKKFAE HHHHHHHHHHHHHHH	20.71	-
779	Ubiquitination	RLQSLYFKKKFAERV HHHHHHHHHHHHHHH	41.31	-
896	Phosphorylation	TELDKEISTLRSGLK HHHHHHHHHHHHHHH	23.60	-
903	Ubiquitination	STLRSGLKAVETELE HHHHHHHHHHHHHHH	54.64	-
1025	Phosphorylation	KVRKAKESSEESGEF HHHHHHHHHHHCCCH	42.20	29899451
1026	Phosphorylation	VRKAKESSEESGEFD HHHHHHHHHHCCCHH	46.61	21743459
1029	Phosphorylation	AKESSEESGEFDDLV HHHHHHHCCCHHHHH	39.30	21082442
1037	Phosphorylation	GEFDDLVSALRSGEV CCHHHHHHHHHHCCC	28.96	29899451
1060	Phosphorylation	KRNRKRISNQVTDSS HHHHHHHHHCCCCCC	25.83	29514104
1066	Phosphorylation	ISNQVTDSSRERPIT HHHCCCCCCCCCCCC	23.17	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DAAM1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DAAM1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DAAM1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DAAM1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.