| UniProt ID | NRP2_MOUSE | |
|---|---|---|
| UniProt AC | O35375 | |
| Protein Name | Neuropilin-2 | |
| Gene Name | Nrp2 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 931 | |
| Subcellular Localization |
Membrane Single-pass type I membrane protein . |
|
| Protein Description | High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.. | |
| Protein Sequence | MDMFPLTWVFLALYFSGHEVRSQQDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSVLYIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPRMEIILQFLTFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSKLRSSTGILSLTFHTDMAVAKDGFSARYYLIHQEPPENFQCNVPLGMESGRIANEQISASSTFSDGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQKGYYVKSYKLEVSTNGEDWMVYRHGKNHKIFQANNDATEVVLNKLHMPLLTRFIRIRPQTWHLGIALRLELFGCRVTDAPCSNMLGMLSGLIADTQISASSTREYLWSPSAARLVSSRSGWFPRNPQAQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQTKLFEGNMHYDTPDIRRFDPVPAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPTVETLGPTVKSEETTTPYPMDEDATECGENCSFEDDKDLQLPSGFNCNFDFPEETCGWVYDHAKWLRSTWISSANPNDRTFPDDKNFLKLQSDGRREGQYGRLISPPVHLPRSPVCMEFQYQAMGGHGVALQVVREASQESKLLWVIREDQGSEWKHGRIILPSYDMEYQIVFEGVIGKGRSGEISIDDIRISTDVPLENCMEPISAFAGEDFKVDIPETHGGEGYEDEIDDEYEGDWSNSSSSTSGAGDPSSGKEKSWLYTLDPILITIIAMSSLGVLLGATCAGLLLYCTCSYSGLSSRSCTTLENYNFELYDGLKHKVKINHQKCCSEA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 152 | N-linked_Glycosylation | GSEDCSKNFTSPNGT CCCCHHCCCCCCCCC | 29.18 | - | |
| 157 | N-linked_Glycosylation | SKNFTSPNGTIESPG HCCCCCCCCCCCCCC | 61.07 | - | |
| 277 | Glutathionylation | EPPENFQCNVPLGME CCCCCCCCCCCCCCC | 4.92 | 24333276 | |
| 454 | Phosphorylation | DTQISASSTREYLWS CCEECCCCCCHHCCC | 31.06 | - | |
| 472 | Phosphorylation | ARLVSSRSGWFPRNP HHHHHCCCCCCCCCC | 42.18 | - | |
| 629 | N-linked_Glycosylation | DATECGENCSFEDDK CCCCCCCCCCCCCCC | 16.41 | - | |
| 781 | Phosphorylation | GVIGKGRSGEISIDD EECCCCCCCCCEECE | 49.82 | 30635358 | |
| 785 | Phosphorylation | KGRSGEISIDDIRIS CCCCCCCEECEEEEC | 18.70 | 30635358 | |
| 839 | N-linked_Glycosylation | EYEGDWSNSSSSTSG CCCCCCCCCCCCCCC | 41.47 | - | |
| 869 (in isoform 5) | Phosphorylation | - | 1.18 | 30635358 | |
| 871 (in isoform 5) | Phosphorylation | - | 6.48 | 30635358 | |
| 874 (in isoform 6) | Phosphorylation | - | 18.96 | 30635358 | |
| 876 (in isoform 6) | Phosphorylation | - | 15.24 | 30635358 | |
| 902 | S-palmitoylation | SGLSSRSCTTLENYN CCCCCCCCCEEECCC | 3.07 | 28680068 | |
| 913 | Phosphorylation | ENYNFELYDGLKHKV ECCCEEEECCCCCEE | 10.77 | 25159016 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NRP2_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NRP2_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NRP2_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of NRP2_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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