MPP6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MPP6_MOUSE
• UniProt AC: Q9JLB0
• Protein Name: MAGUK p55 subfamily member 6
• Gene Name: Mpp6
• Organism: Mus musculus (Mouse).
• Sequence Length: 553
• Subcellular Localization: Membrane; Peripheral membrane protein.
• Protein Sequence: MQQVLENLTELPSSTGAEEIDLIFLKGIMENPIVKSLAKAHERLEDSKLEAVSDNNLELVNEILEDITPLISVDENVAELVGILKEPHFQSLLEAHDIVASKCYDSPPSSPEMNIPSLNNQLPVDAIRILGIHKKAGEPLGVTFRVENNDLVIARILHGGMIDRQGLLHVGDIIKEVNGHEVGNNPKELQELLKNISGSVTLKILPSYRDTITPQQSYVNMERHPAHVRQVFVKCHFDYNPFNDNLIPCKEAGLKFSKGEILQIVNREDPNWWQASHVKEGGSAGLIPSQFLEEKRKAFVRRDWDNSGPFCGTISNKKKKKMMYLTTRNAEFDRHEIQIYEEVAKMPPFQRKTLVLIGAQGVGRRSLKNRFIVLNPARFGTTVPFTSRKPREDEKDGQAYKFVSRSEMEADIKAGKYLEHGEYEGNLYGTKIDSILEVVQTGRTCILDVNPQALKVLRTSEFMPYVVFIAAPELETLRAMHKAVVDAGITTKLLTDSDLKKTVDESARIQRAYNHYFDLIIVNDNLDKAFEKLQTAIEKLRMEPQWVPISWVY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Ubiquitination	IMENPIVKSLAKAHE HHCCHHHHHHHHHHH	40.24	-
104	Phosphorylation	DIVASKCYDSPPSSP HHHHHHCCCCCCCCC	24.16	25159016
106	Phosphorylation	VASKCYDSPPSSPEM HHHHCCCCCCCCCCC	16.55	23429704
109	Phosphorylation	KCYDSPPSSPEMNIP HCCCCCCCCCCCCCC	63.01	23429704
110	Phosphorylation	CYDSPPSSPEMNIPS CCCCCCCCCCCCCCC	30.56	25159016
117	Phosphorylation	SPEMNIPSLNNQLPV CCCCCCCCCCCCCCH	39.67	25159016
135	Ubiquitination	RILGIHKKAGEPLGV EEEEEHHHCCCCEEC	47.68	-
187	Ubiquitination	HEVGNNPKELQELLK CCCCCCHHHHHHHHH	73.51	-
194	Ubiquitination	KELQELLKNISGSVT HHHHHHHHHCCCCEE	65.93	-
199	Phosphorylation	LLKNISGSVTLKILP HHHHCCCCEEEEECC	12.72	22871156
213 (in isoform 2)	Phosphorylation	-	19.69	-
217	Phosphorylation	DTITPQQSYVNMERH CCCCCCCCCCCCCCC	26.29	29514104
218	Phosphorylation	TITPQQSYVNMERHP CCCCCCCCCCCCCCC	7.48	25521595
258	Ubiquitination	EAGLKFSKGEILQIV HHCCCCCCCCEEEEE	64.79	-
279	Ubiquitination	WWQASHVKEGGSAGL CEECCCCCCCCCCCC	45.26	-
311	S-palmitoylation	WDNSGPFCGTISNKK CCCCCCCCCEECCCC	5.45	28680068
400	Phosphorylation	DEKDGQAYKFVSRSE CCCCCCEEEEECHHH	9.32	-
404	Phosphorylation	GQAYKFVSRSEMEAD CCEEEEECHHHHHHH	32.97	29899451
406	Phosphorylation	AYKFVSRSEMEADIK EEEEECHHHHHHHHH	33.51	29899451
416	Ubiquitination	EADIKAGKYLEHGEY HHHHHHCCCCCCCEE	52.07	-
423	Phosphorylation	KYLEHGEYEGNLYGT CCCCCCEECCCEECC	33.46	-
482	Ubiquitination	ETLRAMHKAVVDAGI HHHHHHHHHHHCCCC	29.77	-
513	Phosphorylation	SARIQRAYNHYFDLI HHHHHHHHHHHCCEE	12.50	-
516	Phosphorylation	IQRAYNHYFDLIIVN HHHHHHHHCCEEEEC	8.64	-
528	Ubiquitination	IVNDNLDKAFEKLQT EECCCHHHHHHHHHH	59.13	-
532	Ubiquitination	NLDKAFEKLQTAIEK CHHHHHHHHHHHHHH	39.17	-
539	Ubiquitination	KLQTAIEKLRMEPQW HHHHHHHHHHCCCCC	34.97	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MPP6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MPP6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MPP6_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COR2A_HUMAN	CORO2A	physical	26496610
RBM10_HUMAN	RBM10	physical	26496610
RAIN_HUMAN	RASIP1	physical	26496610
LIN7C_HUMAN	LIN7C	physical	26496610
CE128_HUMAN	CEP128	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.