PPCE_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPCE_MOUSE
• UniProt AC: Q9QUR6
• Protein Name: Prolyl endopeptidase
• Gene Name: Prep
• Organism: Mus musculus (Mouse).
• Sequence Length: 710
• Subcellular Localization: Cytoplasm.
• Protein Description: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long..
• Protein Sequence: MLSFQYPDVYRDETSVQEYHGHKICDPYSWLEDPDSEQTKAFVEAQNKITVPFLEQCPIRGLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNTLSDDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFTCMAWTHDGKGMFYNSYPQQDGKSDGTETSTNLHQKLCYHVLGTDQSEDILCAEFPDEPKWMGGAELSDDGRYVLLSIWEGCDPVNRLWYCDLQQEPNGITGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRNSPNYRLINIDFTDPDESKWKVLVPEHEKDVLEWVACVRSNFLVLCYLHDVKNILQLHDLTTGALLKTFPLDVGSVVGYSGRKKDSEIFYQFTSFLSPGVIYHCDLTKEELEPMVFREVTVKGIDAADYQTIQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYSVSRLIFVRHMGGVLAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKFTIGHAWTTDYGCSDTKQHFEWLLKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIVGRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNIEWIQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MLSFQYPD -------CCCCCCCC	6.80	-
57	S-nitrosocysteine	TVPFLEQCPIRGLYK CCCHHHHCCCCCCCH	1.90	-
57	S-nitrosylation	TVPFLEQCPIRGLYK CCCHHHHCCCCCCCH	1.90	21278135
57	Glutathionylation	TVPFLEQCPIRGLYK CCCHHHHCCCCCCCH	1.90	24333276
71	Phosphorylation	KERMTELYDYPKYSC HHHHHHHHCCCCEEE	13.75	22817900
73	Phosphorylation	RMTELYDYPKYSCHF HHHHHHCCCCEEEEE	6.51	25263469
75	Acetylation	TELYDYPKYSCHFKK HHHHCCCCEEEEEEC	43.50	22826441
78	Glutathionylation	YDYPKYSCHFKKGKR HCCCCEEEEEECCCE	3.87	24333276
120	Phosphorylation	FLDPNTLSDDGTVAL EECCCCCCCCCCEEE	31.45	26525534
157	Acetylation	WVTIKFMKVDGAKEL CEEEEEEEECCCHHC	40.06	-
162	Acetylation	FMKVDGAKELPDVLE EEEECCCHHCCHHHH	66.37	23954790
162	Ubiquitination	FMKVDGAKELPDVLE EEEECCCHHCCHHHH	66.37	-
172	Acetylation	PDVLERVKFTCMAWT CHHHHHHCEEEEEEE	40.97	22826441
196	Ubiquitination	SYPQQDGKSDGTETS CCCCCCCCCCCCCCC	54.38	-
197	Phosphorylation	YPQQDGKSDGTETST CCCCCCCCCCCCCCC	46.96	27841257
211	S-palmitoylation	TNLHQKLCYHVLGTD CHHHHHHHHHHHCCC	2.58	28680068
225	S-palmitoylation	DQSEDILCAEFPDEP CCCCCEEEEECCCCC	3.31	28680068
255	Glutathionylation	LLSIWEGCDPVNRLW EEEEECCCCCCCEEE	3.47	24333276
325	Acetylation	FTDPDESKWKVLVPE CCCCCHHCCEEECCH	49.32	22826441
335	Acetylation	VLVPEHEKDVLEWVA EECCHHHHCHHHHHH	55.85	22826441
457	Acetylation	IPMFIVHKKGIKLDG CCEEEEECCCCCCCC	41.63	22826441
588	Acetylation	MDMLKFHKFTIGHAW HHHHHCCEECCCCEE	47.54	22826441
649	Phosphorylation	DRVVPLHSLKFIATL CCEEEHHHHHHHHHH	40.72	30482847
667	Phosphorylation	VGRSRKQSNPLLIHV HCCCCCCCCCEEEEE	43.37	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPCE_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPCE_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPCE_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PPCE_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.