| UniProt ID | DHC24_MOUSE | |
|---|---|---|
| UniProt AC | Q8VCH6 | |
| Protein Name | Delta(24)-sterol reductase | |
| Gene Name | Dhcr24 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 516 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Single-pass membrane protein. Golgi apparatus membrane Single-pass membrane protein. |
|
| Protein Description | Catalyzes the reduction of the Delta-24 double bond of sterol intermediates.. | |
| Protein Sequence | MEPAVSLAVCALLFLLWVRVKGLEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKLSSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVSMGQVTALLNSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELILADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICEKFTRESQRLENHFVEGLLYSLDEAVIMTGVMTDDVEPSKLNSIGSYYKPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCMSQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGDEAELYVDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMNREEFWEMFDGSLYHKLRKQLGCQDAFPEVYDKICKAARH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 254 | Ubiquitination | GLEAICEKFTRESQR CHHHHHHHHHHHHHH | 47.85 | - | |
| 313 | Acetylation | KHVENYLKTNREGLE HHHHHHHHHCCCCCC | 33.13 | 23954790 | |
| 313 | Ubiquitination | KHVENYLKTNREGLE HHHHHHHHHCCCCCC | 33.13 | 27667366 | |
| 367 | Ubiquitination | PPKISLLKLTQGETL CCCEEEEECCCCHHH | 55.57 | 27667366 | |
| 376 | Ubiquitination | TQGETLRKLYEQHHV CCCHHHHHHHHHHCC | 59.54 | - | |
| 446 | Ubiquitination | AYGEPRVKHFEARSC CCCCCCCCHHHHHHH | 43.80 | - | |
| 459 | Ubiquitination | SCMRQLEKFVRSVHG HHHHHHHHHHHHHHH | 58.72 | 27667366 | |
| 492 | Ubiquitination | FDGSLYHKLRKQLGC CCHHHHHHHHHHHCC | 36.11 | - | |
| 495 | Ubiquitination | SLYHKLRKQLGCQDA HHHHHHHHHHCCCCC | 61.38 | - | |
| 499 | S-palmitoylation | KLRKQLGCQDAFPEV HHHHHHCCCCCCHHH | 4.50 | 28526873 | |
| 509 | Ubiquitination | AFPEVYDKICKAARH CCHHHHHHHHHHHCC | 32.11 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DHC24_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DHC24_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DHC24_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of DHC24_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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