AL3B1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AL3B1_MOUSE
• UniProt AC: Q80VQ0
• Protein Name: Aldehyde dehydrogenase family 3 member B1
• Gene Name: Aldh3b1
• Organism: Mus musculus (Mouse).
• Sequence Length: 468
• Subcellular Localization: Cell membrane ; Lipid-anchor . Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm.
• Protein Description: Oxidizes medium and long chain saturated and unsaturated aldehydes. [PubMed: 25286108 Metabolizes also benzaldehyde (By similarity Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde (By similarity May not metabolize short chain aldehydes. May use both NADP(+) and NAD(+) as cofactors (By similarity May have a protective role against the cytotoxicity induced by lipid peroxidation (By similarity]
• Protein Sequence: MDSFEDKLQQLREAFKEGRTRSAEFRAAQLQGLSHFLRDNKQQLQEALAQDLHKSAFEAEVSEIAISQAEVDLALRNLRSWMKDEKVSKNLATQLDSAFIRKEPFGLVLIIVPWNYPINLTLVPLVGAIAAGNCVVLKPSEISKATEKILAEVLPRYLDQSCFTVVLGGRQETGQLLEHKFDYIFFTGNAYVGKIVMAAAAKHLTPITLELGGKNPCYVDDNCDPQIVANRVAWFRYFNAGQTCVAPDYILCSQEMQERLVPALQNAITRFYGDNPQTSPNLGRIINQKHFKRLQGLLGCGRVAIGGQSDEGERYIAPTVLVDVQETEPVMQEEIFGPILPLVTVRSLDEAIEFMNRREKPLALYAFSKRSQVIKQVLARTSSGGFCGNDGFMHMTLSSLPFGGVGTSGMGRYHGKFSFDTFSNQRACLLRSPGMEKINDLRYPPYSSRNLRVLLVAMEERCCSCTLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDSFEDKL -------CCHHHHHH	9.81	-
3	Phosphorylation	-----MDSFEDKLQQ -----CCHHHHHHHH	29.27	24719451
148	Ubiquitination	EISKATEKILAEVLP HHHHHHHHHHHHHHH	38.37	-
244	Glutathionylation	YFNAGQTCVAPDYIL HCCCCCCEECCCEEE	1.56	24333276
278	Phosphorylation	FYGDNPQTSPNLGRI HHCCCCCCCCCHHHH	47.62	26643407
279	Phosphorylation	YGDNPQTSPNLGRII HCCCCCCCCCHHHHH	13.42	26643407
462	S-palmitoylation	LVAMEERCCSCTLL- HHHCHHHHCCCCCC-	1.96	25286108
463	S-palmitoylation	VAMEERCCSCTLL-- HHCHHHHCCCCCC--	4.72	25286108
465	Methylation	MEERCCSCTLL---- CHHHHCCCCCC----	1.62	-
465	Geranylgeranylation	MEERCCSCTLL---- CHHHHCCCCCC----	1.62	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AL3B1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AL3B1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AL3B1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AL3B1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.