SPG7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPG7_MOUSE
• UniProt AC: Q3ULF4
• Protein Name: Paraplegin {ECO:0000303|PubMed:14722615}
• Gene Name: Spg7 {ECO:0000312|MGI:MGI:2385906}
• Organism: Mus musculus (Mouse).
• Sequence Length: 781
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein .
• Protein Description: ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function (By similarity)..
• Protein Sequence: MAAALLLLRGLRPGPEPRPRRLWGLLSGRGPGLSSGAGARRPYAARGTPVGPAAAGGHAPQSLLLRILTPSFEGISGLLLKQHIVPNAVRLWPLSGSTLYFNTSRMKQKNKDNDKPKGKTPEDDEEEKRRKEREDQMYRERLRTLFIIALVMSLLNSLSTSGGSISWADFVNEMLAKGEVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIESKDRIPVSYKRTGFFGNALYALGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDGKTGKGVSFQDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTSMSGFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADVLDNALMRPGRLDRHVFIDLPTLQERREIFEQHLKGLKLTQPSSFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSVHTFNFEYAVERVIAGTAKKSKILSKEEQRVVAFHESGHALVGWLLEHTEAVMKVSIAPRTNAALGFSQMLPRDQYLFTKEQLFERMCMALGGRAAEAISFSRVTSGAQDDLRKVTRIAYSMVKQFGMAPSIGPVSFPEAQEGLMGIGRRPFSQGLQQMMDHEAKLLVAKAYRHTEKVLLDNLDKLQALANALLEKEVINYEDIEALIGPPPHGPKKMIAPQKWIDAEKERQASGEEEAPAP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
248	Phosphorylation	IPVSYKRTGFFGNAL CCCCEECCCCHHHHH	33.90	28285833
270	Phosphorylation	VGLAILWYVFRLAGM HHHHHHHHHHHHHCC	6.05	28285833
505	Nitrated tyrosine	LTQPSSFYSQRLAEL CCCCCCHHHHHHHHH	13.07	-
505	Nitration	LTQPSSFYSQRLAEL CCCCCCHHHHHHHHH	13.07	16800626
505	Nitration	LTQPSSFYSQRLAEL CCCCCCHHHHHHHHH	13.07	16800626
517	Phosphorylation	AELTPGFSGADIANI HHHCCCCCHHHHHHH	38.70	-
607	Phosphorylation	TNAALGFSQMLPRDQ CCCCCCHHHCCCHHH	16.94	-
619	Acetylation	RDQYLFTKEQLFERM HHHCCCCHHHHHHHH	35.81	23954790
619	Succinylation	RDQYLFTKEQLFERM HHHCCCCHHHHHHHH	35.81	23954790
639	Phosphorylation	GRAAEAISFSRVTSG CHHHHHHHHHHHCCC	24.98	26160508
641	Phosphorylation	AAEAISFSRVTSGAQ HHHHHHHHHHCCCCH	21.03	25266776
709	Acetylation	EAKLLVAKAYRHTEK HHHHHHHHHHHHCHH	38.17	23201123
716	Acetylation	KAYRHTEKVLLDNLD HHHHHCHHHHHCCHH	39.06	23201123
762	Ubiquitination	KKMIAPQKWIDAEKE CCCCCCHHHCCHHHH	45.09	-
768	Ubiquitination	QKWIDAEKERQASGE HHHCCHHHHHHHCCC	60.97	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPG7_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPG7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPG7_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SPG7_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Nitration

"Endogenously nitrated proteins in mouse brain: links toneurodegenerative disease.";
Sacksteder C.A., Qian W.-J., Knyushko T.V., Wang H., Chin M.H.,Lacan G., Melega W.P., Camp D.G. II, Smith R.D., Smith D.J.,Squier T.C., Bigelow D.J.;
Biochemistry 45:8009-8022(2006).
Cited for: NITRATION [LARGE SCALE ANALYSIS] AT TYR-505, AND MASS SPECTROMETRY.
PubMed: 16800626