S38AA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S38AA_MOUSE
• UniProt AC: Q5I012
• Protein Name: Putative sodium-coupled neutral amino acid transporter 10
• Gene Name: Slc38a10
• Organism: Mus musculus (Mouse).
• Sequence Length: 1090
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Putative sodium-dependent amino acid/proton antiporter..
• Protein Sequence: MTAASTSKWGLITNVVNSIVGVSVLTMPFCFKQCGIVLGALLLVFCSWMTHQSCMFLVKSASLSKRRTYAGLAFHAYGKAGKMLVETSMIGLMLGSCITFYVVIGDLGSNFFAPLLGLQVTRTVRVFLLFAVSLFIVLPLSLQRNMMASIQSFSAMALLFYTVFMFVIVLSSLKHGLFSGQWLRQVSYIRWEGVFRCVPIFGMSFACQSQVLPTYDSLDEPSVKTMSSIFASSLNVVTAFYVMVGFFGYVSFTDATTGNVLIHFPSNPVTEMIRVGFVMSVAVGFPMMILPCRQALNTLLFEQQQKDGTFAAGGYMPPLRFKVLTLSVVFGTMVGGVMIPNVETILGFTGATMGSLICFICPALIYKKAHKNAPSAQVVLWVGLGILVVSTLTTLSVTEEAPLDLTQEARSGHRGDAEGAMKVEAARLSVQDPVVVVAEDSQEKLKPAEDKEVLEQAQIKGPVDVPGGEAPKEKQEAAQLDRPGQGIAVPMGEAHRHEPPIPHDKVVVDEGQDQEGPEEKKPPPRLPDEGDPAGRGQGAPPLPESEKEKQEPERGGEGKRPGQVLAVGETEHPQKVPEANGQPPVQPRKEDSRPGNRDPQPAAQARDSVELKALAADDGREPAQKAGGALWKPVESAAESDAGGKAGLPVQRPEAAEQREKKEAEQQGGDQAGSKLEAEIKKLVAEAGRAEMLDHAVLLQVIQEQQVQQKRLLDQQEKLLAVIEEQHKEIRQQRQEGEEDKPKPADVQPEPGVAVLRGQEEEAEHAGETLGDDPSQPLQPVLGAPRGRPAPSQDMGQHLPGEVKVLPGRDLADLPAGGSETEPQGAPIDLREDPKAAIKAAGAGKELVPGDLEAVHKAAPPEVPKSPEKQVAKAVAGQRQDVFGEGSEERKETGKEAMAPGADTQKEAVQPLVGAEAKDTKSRQSGPTKAPVQTQAKFHPEPQAIFDTGQGSHPEVRSEAPRAVHIPPEEQHKGKGGAAIQEAKQRPDPNSGPKLAVPAGQKPENAKPNRDLKVQAGSDLRRRRRDLASHPEQELAPKDGVIISFNSLPNVQVNDLRSALDTQLRQAAGAALQVVHSRQIKQLSGDLEEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
429	Phosphorylation	KVEAARLSVQDPVVV HHHHHHCCCCCCEEE	16.51	25338131
441	Phosphorylation	VVVVAEDSQEKLKPA EEEEECCCHHHCCCC	31.57	25521595
608	Phosphorylation	PAAQARDSVELKALA HHHHHCCHHHHHHHH	16.37	26824392
636	Phosphorylation	ALWKPVESAAESDAG CCCCCHHHHHHCCCC	32.77	27180971
640	Phosphorylation	PVESAAESDAGGKAG CHHHHHHCCCCCCCC	28.21	22817900
674 (in isoform 3)	Phosphorylation	-	36.76	20531401
674 (in isoform 4)	Phosphorylation	-	36.76	20531401
710	Ubiquitination	QEQQVQQKRLLDQQE HHHHHHHHHHHHHHH	28.11	22790023
769	Phosphorylation	EAEHAGETLGDDPSQ HHHHHCCCCCCCCCC	34.81	-
819	Phosphorylation	ADLPAGGSETEPQGA HHCCCCCCCCCCCCC	40.19	30635358
821	Phosphorylation	LPAGGSETEPQGAPI CCCCCCCCCCCCCCC	55.45	30635358
866	Phosphorylation	APPEVPKSPEKQVAK CCCCCCCCHHHHHHH	32.02	30635358
887	Phosphorylation	QDVFGEGSEERKETG CCCCCCCCHHHHHHC	31.79	27087446
893	Phosphorylation	GSEERKETGKEAMAP CCHHHHHHCCCCCCC	57.50	25159016
991	Phosphorylation	KQRPDPNSGPKLAVP HHCCCCCCCCCCCCC	62.96	27841257
1018	Phosphorylation	DLKVQAGSDLRRRRR CCCCCCCCHHHHHHH	36.17	28285833

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S38AA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S38AA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S38AA_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of S38AA_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-441 AND SER-887, ANDMASS SPECTROMETRY.
PubMed: 17203969