| UniProt ID | GPD1L_MOUSE | |
|---|---|---|
| UniProt AC | Q3ULJ0 | |
| Protein Name | Glycerol-3-phosphate dehydrogenase 1-like protein | |
| Gene Name | Gpd1l | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 351 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.. | |
| Protein Sequence | MAAAPLKVCIVGSGNWGSAVAKIIGSNVKTLQKFSSTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAVPNLSEAVQDADLLVFVIPHQFIHKICDEITGRVPEKALGITLIKGIDEGPDGLKLISDIIREKMGIDISVLMGANIASEVAAEKFCETTIGSKVMQNGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFAKIFCKGQVSTATFLESCGVADLITTCYGGRNRRVAEAFARTGKTIEELEKELLNGQKLQGPQTSAEVYRILRQKGLLDKFPLFTAVYQICYEGRPVTQMLSCLQSHPEHI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | S-nitrosocysteine | AAAPLKVCIVGSGNW CCCCEEEEEECCCCH | 1.67 | - | |
| 9 | S-nitrosylation | AAAPLKVCIVGSGNW CCCCEEEEEECCCCH | 1.67 | 21278135 | |
| 29 | Ubiquitination | KIIGSNVKTLQKFSS HHHCCCCHHHHHHCC | 48.01 | - | |
| 29 | Malonylation | KIIGSNVKTLQKFSS HHHCCCCHHHHHHCC | 48.01 | 26320211 | |
| 104 | S-nitrosocysteine | HQFIHKICDEITGRV HHHHHHHHHHHCCCC | 4.59 | - | |
| 104 | S-nitrosylation | HQFIHKICDEITGRV HHHHHHHHHHHCCCC | 4.59 | 21278135 | |
| 104 | S-palmitoylation | HQFIHKICDEITGRV HHHHHHHHHHHCCCC | 4.59 | 28526873 | |
| 108 | Phosphorylation | HKICDEITGRVPEKA HHHHHHHCCCCCHHH | 19.52 | - | |
| 156 | Phosphorylation | LMGANIASEVAAEKF HCCCCHHHHHHHHHH | 28.89 | - | |
| 180 | Ubiquitination | MQNGLLFKELLQTPN HHCCCHHHHHHCCCC | 47.63 | - | |
| 216 | S-nitrosocysteine | VAVGAGFCDGLRCGD EEECCCCCCCCCCCC | 3.87 | - | |
| 216 | S-nitrosylation | VAVGAGFCDGLRCGD EEECCCCCCCCCCCC | 3.87 | 21278135 | |
| 216 | S-palmitoylation | VAVGAGFCDGLRCGD EEECCCCCCCCCCCC | 3.87 | 28526873 | |
| 291 | Succinylation | KTIEELEKELLNGQK CCHHHHHHHHHCCCC | 67.31 | - | |
| 298 | Ubiquitination | KELLNGQKLQGPQTS HHHHCCCCCCCCCCH | 44.14 | - | |
| 328 | Phosphorylation | FPLFTAVYQICYEGR CCHHHHHHHHHHCCC | 6.95 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GPD1L_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GPD1L_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GPD1L_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of GPD1L_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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