GRM2B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRM2B_MOUSE
• UniProt AC: Q6PEM6
• Protein Name: GRAM domain-containing protein 2B
• Gene Name: Gramd2b
• Organism: Mus musculus (Mouse).
• Sequence Length: 445
• Protein Sequence: MVKKRLSSSDNVFKFEIPSNSKTSAEAPHSSTDSPSSVFLSSEAENGAEDRRRVSKSPTAQSPTSSVEAESPDQKRSLGLWSKSSFDGSSLLSDKNDCKTESKTDSKTERKKSSSSSQYKANMHFHKLFLDVPTEEPLRQSFTCALQKEILYQGKLFVSENWICFHSKVFGKDTKISIPAFSVTLIKKTKTALLVPNALIIATVTDRYIFVSLLSRDSTYKLIKSVCGHLENTSVGNSPNPSSAENSFRADRPSSLPLDFNDEFSDLDGVVRQRRQDLEGYSSSGSQTPESENSRDFHVTESQTVLNVTKGETKPPRTDAHGSRAPDGKAKILPAHGQSETIGILHKMESRKCPTLHHILIVYAIIVCALIISTFYMRYRINTLEERLGTLTSIMDPHSTEQTAPSGLGSQMQLNVEVLCQELTANIVKLEKIQNNLQKLLENGD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MVKKRLSS -------CCCCCCCC		-
7	Phosphorylation	-MVKKRLSSSDNVFK -CCCCCCCCCCCEEE		25521595
8	Phosphorylation	MVKKRLSSSDNVFKF CCCCCCCCCCCEEEE		25521595
9	Phosphorylation	VKKRLSSSDNVFKFE CCCCCCCCCCEEEEE		21743459
19	Phosphorylation	VFKFEIPSNSKTSAE EEEEEECCCCCCCCC		30635358
21	Phosphorylation	KFEIPSNSKTSAEAP EEEECCCCCCCCCCC		30635358
42	Phosphorylation	PSSVFLSSEAENGAE CCCEECCCCCCCCHH		27841257
55	Phosphorylation	AEDRRRVSKSPTAQS HHHHCCCCCCCCCCC		23684622
57	Phosphorylation	DRRRVSKSPTAQSPT HHCCCCCCCCCCCCC		25521595
59	Phosphorylation	RRVSKSPTAQSPTSS CCCCCCCCCCCCCCC		25195567
62	Phosphorylation	SKSPTAQSPTSSVEA CCCCCCCCCCCCCEE		23684622
64	Phosphorylation	SPTAQSPTSSVEAES CCCCCCCCCCCEECC		25521595
65	Phosphorylation	PTAQSPTSSVEAESP CCCCCCCCCCEECCC		30635358
66	Phosphorylation	TAQSPTSSVEAESPD CCCCCCCCCEECCCC		30635358
71	Phosphorylation	TSSVEAESPDQKRSL CCCCEECCCCCCHHC		29899451
83	Ubiquitination	RSLGLWSKSSFDGSS HHCCCCCCCCCCCHH		-
84	Phosphorylation	SLGLWSKSSFDGSSL HCCCCCCCCCCCHHH		26239621
85	Phosphorylation	LGLWSKSSFDGSSLL CCCCCCCCCCCHHHC		25521595
89	Phosphorylation	SKSSFDGSSLLSDKN CCCCCCCHHHCCCCC		23140645
90	Phosphorylation	KSSFDGSSLLSDKND CCCCCCHHHCCCCCC		23984901
93	Phosphorylation	FDGSSLLSDKNDCKT CCCHHHCCCCCCCCC		27717184
100	Phosphorylation	SDKNDCKTESKTDSK CCCCCCCCCCCCCCC		29472430
102	Phosphorylation	KNDCKTESKTDSKTE CCCCCCCCCCCCCCC		29472430
104	Phosphorylation	DCKTESKTDSKTERK CCCCCCCCCCCCCHH		29472430
106	Phosphorylation	KTESKTDSKTERKKS CCCCCCCCCCCHHHC		29472430
115	Phosphorylation	TERKKSSSSSQYKAN CCHHHCCCCHHHHHH		27841257
119	Phosphorylation	KSSSSSQYKANMHFH HCCCCHHHHHHHHHH		28576409
152	Phosphorylation	ALQKEILYQGKLFVS HHHHHHHHCCEEEEE		25177544
177	Phosphorylation	FGKDTKISIPAFSVT HCCCCEEEEEEEEEE		21454597
184	Phosphorylation	SIPAFSVTLIKKTKT EEEEEEEEEECCCCC		21454597
225	Phosphorylation	STYKLIKSVCGHLEN HHHHHHHHHHCCCCC		26239621
233	Phosphorylation	VCGHLENTSVGNSPN HHCCCCCCCCCCCCC		20139300
234	Phosphorylation	CGHLENTSVGNSPNP HCCCCCCCCCCCCCC		25521595
238	Phosphorylation	ENTSVGNSPNPSSAE CCCCCCCCCCCCHHC		27818261
242	Phosphorylation	VGNSPNPSSAENSFR CCCCCCCCHHCCCCC		21743459
243	Phosphorylation	GNSPNPSSAENSFRA CCCCCCCHHCCCCCC		23984901
247	Phosphorylation	NPSSAENSFRADRPS CCCHHCCCCCCCCCC		25293948
254	Phosphorylation	SFRADRPSSLPLDFN CCCCCCCCCCCCCCC		21743459
255	Phosphorylation	FRADRPSSLPLDFND CCCCCCCCCCCCCCC		27818261
265	Phosphorylation	LDFNDEFSDLDGVVR CCCCCCCCCCHHHHH		26824392
300	Phosphorylation	NSRDFHVTESQTVLN CCCCEEECCEEEEEE		25521595
302	Phosphorylation	RDFHVTESQTVLNVT CCEEECCEEEEEEEC		25521595
304	Phosphorylation	FHVTESQTVLNVTKG EEECCEEEEEEECCC		23140645
339	Phosphorylation	ILPAHGQSETIGILH EEECCCCCCCHHHHH		27841257
341	Phosphorylation	PAHGQSETIGILHKM ECCCCCCCHHHHHHH		27841257
390	Phosphorylation	TLEERLGTLTSIMDP CHHHHHCCHHHHCCC		25159016
392	Phosphorylation	EERLGTLTSIMDPHS HHHHCCHHHHCCCCC		25159016
393	Phosphorylation	ERLGTLTSIMDPHST HHHCCHHHHCCCCCC		25159016
399	Phosphorylation	TSIMDPHSTEQTAPS HHHCCCCCCCCCCCC		25159016
400	Phosphorylation	SIMDPHSTEQTAPSG HHCCCCCCCCCCCCC		25159016
403	Phosphorylation	DPHSTEQTAPSGLGS CCCCCCCCCCCCCCC		25159016
406	Phosphorylation	STEQTAPSGLGSQMQ CCCCCCCCCCCCCHH		25159016
410	Phosphorylation	TAPSGLGSQMQLNVE CCCCCCCCCHHHCHH		25159016
424	Phosphorylation	EVLCQELTANIVKLE HHHHHHHHHHHHHHH		25159016

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRM2B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRM2B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRM2B_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GRM2B_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.