SRPRB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRPRB_MOUSE
• UniProt AC: P47758
• Protein Name: Signal recognition particle receptor subunit beta
• Gene Name: Srprb
• Organism: Mus musculus (Mouse).
• Sequence Length: 269
• Subcellular Localization: Endoplasmic reticulum membrane; Single-pass membrane protein.
• Protein Description: Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR..
• Protein Sequence: MASANTRRVGDGAGGAFQPYLDSLRQELQQRDPTLLSVAVALLAVLLTLVFWKFIWSRKSSQRAVLFVGLCDSGKTLLFVRLLTGQYRDTQTSITDSSAIYKVNNNRGNSLTLIDLPGHESLRFQLLDRFKSSARAVVFVVDSAAFQREVKDVAEFLYQVLIDSMALKNSPSLLIACNKQDIAMAKSAKLIQQQLEKELNTLRVTRSAAPSTLDSSSTAPAQLGKKGKEFEFSQLPLKVEFLECSAKGGRGDTGSADIQDLEKWLAKIA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
110	Phosphorylation	VNNNRGNSLTLIDLP EECCCCCEEEEEECC	26.09	25159016
112	Phosphorylation	NNRGNSLTLIDLPGH CCCCCEEEEEECCCC	22.84	29472430
172	Phosphorylation	MALKNSPSLLIACNK HHHCCCCCEEEEECH	35.31	21454597
177	S-palmitoylation	SPSLLIACNKQDIAM CCCEEEEECHHHHHH	5.32	28526873
186	Malonylation	KQDIAMAKSAKLIQQ HHHHHHHHHHHHHHH	37.55	26320211
189	Ubiquitination	IAMAKSAKLIQQQLE HHHHHHHHHHHHHHH	53.89	27667366
189	Malonylation	IAMAKSAKLIQQQLE HHHHHHHHHHHHHHH	53.89	26320211
197	Ubiquitination	LIQQQLEKELNTLRV HHHHHHHHHHCHHHH	75.89	-
207	Phosphorylation	NTLRVTRSAAPSTLD CHHHHCCCCCCCCCC	21.29	29472430
211	Phosphorylation	VTRSAAPSTLDSSST HCCCCCCCCCCCCCC	36.55	29472430
212	Phosphorylation	TRSAAPSTLDSSSTA CCCCCCCCCCCCCCC	33.26	24719451
215	Phosphorylation	AAPSTLDSSSTAPAQ CCCCCCCCCCCCCHH	29.33	29472430
216	Phosphorylation	APSTLDSSSTAPAQL CCCCCCCCCCCCHHH	31.23	29472430
217	Phosphorylation	PSTLDSSSTAPAQLG CCCCCCCCCCCHHHC	32.32	29472430
218	Phosphorylation	STLDSSSTAPAQLGK CCCCCCCCCCHHHCC	38.31	29472430
225	Malonylation	TAPAQLGKKGKEFEF CCCHHHCCCCCEEEC	67.93	26320211
228	Malonylation	AQLGKKGKEFEFSQL HHHCCCCCEEECCCC	69.02	26320211
245	Phosphorylation	KVEFLECSAKGGRGD EEEEEECCCCCCCCC	24.52	25338131
253	Phosphorylation	AKGGRGDTGSADIQD CCCCCCCCCCCCHHH	35.54	26643407
255	Phosphorylation	GGRGDTGSADIQDLE CCCCCCCCCCHHHHH	25.51	25521595
263	Acetylation	ADIQDLEKWLAKIA- CCHHHHHHHHHHHC-	55.60	23954790

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SRPRB_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SRPRB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRPRB_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SRPRB_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.