| UniProt ID | NECT2_MOUSE | |
|---|---|---|
| UniProt AC | P32507 | |
| Protein Name | Nectin-2 | |
| Gene Name | Nectin2 {ECO:0000250|UniProtKB:Q92692} | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 530 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein . |
|
| Protein Description | Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein.. | |
| Protein Sequence | MARAAVLPPSRLSPTLPLLPLLLLLLQETGAQDVRVRVLPEVRGRLGGTVELPCHLLPPTTERVSQVTWQRLDGTVVAAFHPSFGVDFPNSQFSKDRLSFVRARPETNADLRDATLAFRGLRVEDEGNYTCEFATFPNGTRRGVTWLRVIAQPENHAEAQEVTIGPQSVAVARCVSTGGRPPARITWISSLGGEAKDTQEPGIQAGTVTIISRYSLVPVGRADGVKVTCRVEHESFEEPILLPVTLSVRYPPEVSISGYDDNWYLGRSEAILTCDVRSNPEPTDYDWSTTSGVFPASAVAQGSQLLVHSVDRMVNTTFICTATNAVGTGRAEQVILVRESPSTAGAGATGGIIGGIIAAIIATAVAGTGILICRQQRKEQRLQAADEEEELEGPPSYKPPTPKAKLEEPEMPSQLFTLGASEHSPVKTPYFDAGVSCADQEMPRYHELPTLEERSGPLLLGATGLGPSLLVPPGPNVVEGVSLSLEDEEEDDEEEDFLDKINPIYDALSYPSPSDSYQSKDFFVSRAMYV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 128 | N-linked_Glycosylation | LRVEDEGNYTCEFAT CEEEECCCEEEEEEE | 22902367 | ||
| 138 | N-linked_Glycosylation | CEFATFPNGTRRGVT EEEEECCCCCCCCEE | 22902367 | ||
| 315 | N-linked_Glycosylation | HSVDRMVNTTFICTA EECCCCCCCEEEEEC | 19349973 | ||
| 340 | Phosphorylation | QVILVRESPSTAGAG EEEEEEECCCCCCCC | 23140645 | ||
| 342 | Phosphorylation | ILVRESPSTAGAGAT EEEEECCCCCCCCCC | 23140645 | ||
| 343 | Phosphorylation | LVRESPSTAGAGATG EEEECCCCCCCCCCC | 23140645 | ||
| 349 | Phosphorylation | STAGAGATGGIIGGI CCCCCCCCCCHHHHH | 23140645 | ||
| 363 | Phosphorylation | IIAAIIATAVAGTGI HHHHHHHHHHHCCCE | 23140645 | ||
| 368 | Phosphorylation | IATAVAGTGILICRQ HHHHHHCCCEEEECH | 23140645 | ||
| 382 (in isoform 2) | Phosphorylation | - | 29472430 | ||
| 395 (in isoform 2) | Phosphorylation | - | 29472430 | ||
| 396 | Phosphorylation | EELEGPPSYKPPTPK HHHCCCCCCCCCCCC | 21082442 | ||
| 397 | Phosphorylation | ELEGPPSYKPPTPKA HHCCCCCCCCCCCCC | 25619855 | ||
| 398 | Ubiquitination | LEGPPSYKPPTPKAK HCCCCCCCCCCCCCC | 22790023 | ||
| 401 | Phosphorylation | PPSYKPPTPKAKLEE CCCCCCCCCCCCCCC | 26824392 | ||
| 403 | Ubiquitination | SYKPPTPKAKLEEPE CCCCCCCCCCCCCCC | 22790023 | ||
| 405 | Ubiquitination | KPPTPKAKLEEPEMP CCCCCCCCCCCCCCC | 22790023 | ||
| 412 (in isoform 2) | Phosphorylation | - | 25195567 | ||
| 413 | Phosphorylation | LEEPEMPSQLFTLGA CCCCCCCHHEEECCC | 25293948 | ||
| 417 | Phosphorylation | EMPSQLFTLGASEHS CCCHHEEECCCCCCC | 26643407 | ||
| 421 | Phosphorylation | QLFTLGASEHSPVKT HEEECCCCCCCCCCC | 26824392 | ||
| 424 | Phosphorylation | TLGASEHSPVKTPYF ECCCCCCCCCCCCCC | 26824392 | ||
| 445 | Phosphorylation | ADQEMPRYHELPTLE CCCCCCCCCCCCCHH | 29514104 | ||
| 446 (in isoform 2) | Phosphorylation | - | 25195567 | ||
| 450 | Phosphorylation | PRYHELPTLEERSGP CCCCCCCCHHHHCCC | 26824392 | ||
| 458 (in isoform 2) | Phosphorylation | - | 29550500 | ||
| 505 | Phosphorylation | LDKINPIYDALSYPS HHHHHHHHHHHCCCC | 10962558 | ||
| 510 | Phosphorylation | PIYDALSYPSPSDSY HHHHHHCCCCCCHHC | 26643407 | ||
| 512 | Phosphorylation | YDALSYPSPSDSYQS HHHHCCCCCCHHCCC | 26643407 | ||
| 514 | Phosphorylation | ALSYPSPSDSYQSKD HHCCCCCCHHCCCCC | 26643407 | ||
| 516 | Phosphorylation | SYPSPSDSYQSKDFF CCCCCCHHCCCCCCE | 26643407 | ||
| 517 | Phosphorylation | YPSPSDSYQSKDFFV CCCCCHHCCCCCCEE | 26643407 | ||
| 519 | Phosphorylation | SPSDSYQSKDFFVSR CCCHHCCCCCCEEEE | 26643407 | ||
| 520 | Ubiquitination | PSDSYQSKDFFVSRA CCHHCCCCCCEEEEE | 22790023 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 505 | Y | Phosphorylation | Kinase | SRC | P05480 | PSP |
| 505 | Y | Phosphorylation | Kinase | SRC64 | - | PhosphoELM |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NECT2_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NECT2_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of NECT2_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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