| UniProt ID | RL1D1_MOUSE | |
|---|---|---|
| UniProt AC | Q8BVY0 | |
| Protein Name | Ribosomal L1 domain-containing protein 1 | |
| Gene Name | Rsl1d1 {ECO:0000312|MGI:MGI:1913659} | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 452 | |
| Subcellular Localization | Nucleus, nucleolus . | |
| Protein Description | Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.. | |
| Protein Sequence | MKGSASESPSASVAEATTTDVQVTPTALLQLDREQIRKAVEVISNRSKSKKNNNELLLSGSENLFLMVILWKIPEKELRVKVPLPHSILSESSDVCLFTKDEFDSPEQTEGFYKKLLKKHGVNTISQIIPFKTLKTEYKAYEAKLRLLGSFEVFITDARIRRHLPSHIGRHFYQRKKVPVSVNLLAKNLSKEINRCITGTVLNISKRGSCSTIRIGHTGMETEHIVDNILAVSEMLSEKLPEKWQSVKLLFLKTEKSVSLPIFSSFVTSQDENAVSLRSLRKQELKKRKRENAKLKKESKMLRKKSKKATSLLTQSGLASSAPAKSPGAQKKKTNKAHKKQKVTEECEEAIPQLVPIGETPDKENVKMQENITGKTPKSKSDPSTPKGKKRKALLATETPEASAPGTSGKKQKKDVQEFRKPEASSFSTPRKSGKKASNTPRDKKTKAAHSN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MKGSASES -------CCCCCCCC | - | ||
| 4 | Phosphorylation | ----MKGSASESPSA ----CCCCCCCCCCC | 25159016 | ||
| 6 | Phosphorylation | --MKGSASESPSASV --CCCCCCCCCCCCH | 25159016 | ||
| 8 | Phosphorylation | MKGSASESPSASVAE CCCCCCCCCCCCHHC | 27087446 | ||
| 10 | Phosphorylation | GSASESPSASVAEAT CCCCCCCCCCHHCCC | 25159016 | ||
| 12 | Phosphorylation | ASESPSASVAEATTT CCCCCCCCHHCCCCC | 25159016 | ||
| 17 | Phosphorylation | SASVAEATTTDVQVT CCCHHCCCCCCCCCC | 26643407 | ||
| 18 | Phosphorylation | ASVAEATTTDVQVTP CCHHCCCCCCCCCCH | 25159016 | ||
| 19 | Phosphorylation | SVAEATTTDVQVTPT CHHCCCCCCCCCCHH | 25159016 | ||
| 24 | Phosphorylation | TTTDVQVTPTALLQL CCCCCCCCHHHHHHC | 20469934 | ||
| 26 | Phosphorylation | TDVQVTPTALLQLDR CCCCCCHHHHHHCCH | 25159016 | ||
| 47 | Phosphorylation | VEVISNRSKSKKNNN HHHHHCCCCCCCCCC | 29514104 | ||
| 105 | Phosphorylation | FTKDEFDSPEQTEGF EECCCCCCHHHCHHH | 28066266 | ||
| 109 | Phosphorylation | EFDSPEQTEGFYKKL CCCCHHHCHHHHHHH | 28066266 | ||
| 187 | Acetylation | VSVNLLAKNLSKEIN CCHHHHHHHHHHHHH | 22826441 | ||
| 187 | Ubiquitination | VSVNLLAKNLSKEIN CCHHHHHHHHHHHHH | - | ||
| 279 | Phosphorylation | ENAVSLRSLRKQELK CCCCCHHHHHHHHHH | 24759943 | ||
| 310 | Phosphorylation | RKKSKKATSLLTQSG HHHHHHHHHHHHHHC | 25159016 | ||
| 311 | Phosphorylation | KKSKKATSLLTQSGL HHHHHHHHHHHHHCC | 28066266 | ||
| 314 | Phosphorylation | KKATSLLTQSGLASS HHHHHHHHHHCCCCC | 25159016 | ||
| 316 | Phosphorylation | ATSLLTQSGLASSAP HHHHHHHHCCCCCCC | 25159016 | ||
| 320 | Phosphorylation | LTQSGLASSAPAKSP HHHHCCCCCCCCCCC | 25159016 | ||
| 321 | Phosphorylation | TQSGLASSAPAKSPG HHHCCCCCCCCCCCC | 25159016 | ||
| 326 | Phosphorylation | ASSAPAKSPGAQKKK CCCCCCCCCCCCHHH | 26824392 | ||
| 332 | Acetylation | KSPGAQKKKTNKAHK CCCCCCHHHCCHHHH | 7615675 | ||
| 333 | Acetylation | SPGAQKKKTNKAHKK CCCCCHHHCCHHHHH | 6569845 | ||
| 334 | Phosphorylation | PGAQKKKTNKAHKKQ CCCCHHHCCHHHHHH | - | ||
| 339 | Acetylation | KKTNKAHKKQKVTEE HHCCHHHHHHHHHHH | 6569809 | ||
| 344 | Phosphorylation | AHKKQKVTEECEEAI HHHHHHHHHHHHHHH | 25777480 | ||
| 360 | Phosphorylation | QLVPIGETPDKENVK HCCCCCCCCCHHHCC | 26824392 | ||
| 376 | Phosphorylation | QENITGKTPKSKSDP CCCCCCCCCCCCCCC | 25263469 | ||
| 384 | Phosphorylation | PKSKSDPSTPKGKKR CCCCCCCCCCCCCCH | 26745281 | ||
| 385 | Phosphorylation | KSKSDPSTPKGKKRK CCCCCCCCCCCCCHH | 28507225 | ||
| 397 | Phosphorylation | KRKALLATETPEASA CHHEEEECCCCCCCC | 25168779 | ||
| 399 | Phosphorylation | KALLATETPEASAPG HEEEECCCCCCCCCC | 26824392 | ||
| 403 | Phosphorylation | ATETPEASAPGTSGK ECCCCCCCCCCCCCC | 26745281 | ||
| 407 | Phosphorylation | PEASAPGTSGKKQKK CCCCCCCCCCCCCCC | 25168779 | ||
| 408 | Phosphorylation | EASAPGTSGKKQKKD CCCCCCCCCCCCCCC | 22942356 | ||
| 410 | Acetylation | SAPGTSGKKQKKDVQ CCCCCCCCCCCCCHH | 23236377 | ||
| 411 | Acetylation | APGTSGKKQKKDVQE CCCCCCCCCCCCHHH | 30985575 | ||
| 425 | Phosphorylation | EFRKPEASSFSTPRK HHCCCCHHCCCCCCC | 24453211 | ||
| 426 | Phosphorylation | FRKPEASSFSTPRKS HCCCCHHCCCCCCCC | 23429704 | ||
| 428 | Phosphorylation | KPEASSFSTPRKSGK CCCHHCCCCCCCCCC | 23429704 | ||
| 429 | Phosphorylation | PEASSFSTPRKSGKK CCHHCCCCCCCCCCC | 26824392 | ||
| 432 | Acetylation | SSFSTPRKSGKKASN HCCCCCCCCCCCCCC | - | ||
| 433 | Phosphorylation | SFSTPRKSGKKASNT CCCCCCCCCCCCCCC | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RL1D1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RL1D1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RL1D1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of RL1D1_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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