MOB1A_MOUSE - dbPTM
MOB1A_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MOB1A_MOUSE
UniProt AC Q921Y0
Protein Name MOB kinase activator 1A
Gene Name Mob1a
Organism Mus musculus (Mouse).
Sequence Length 216
Subcellular Localization
Protein Description Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38 (By similarity)..
Protein Sequence MSFLFSSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRQAVMLPEGEDLNEWIAVNTVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLGSKDR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSFLFSSRS
------CCCCCCCCC
30.56-
2Phosphorylation------MSFLFSSRS
------CCCCCCCCC
30.5630352176
6Phosphorylation--MSFLFSSRSSKTF
--CCCCCCCCCCCCC
27.3023984901
7Phosphorylation-MSFLFSSRSSKTFK
-CCCCCCCCCCCCCC
28.9323984901
9PhosphorylationSFLFSSRSSKTFKPK
CCCCCCCCCCCCCCC
37.8323984901
10PhosphorylationFLFSSRSSKTFKPKK
CCCCCCCCCCCCCCC
34.3125266776
12PhosphorylationFSSRSSKTFKPKKNI
CCCCCCCCCCCCCCC
38.5521454597
23PhosphorylationKKNIPEGSHQYELLK
CCCCCCCCHHHHHHH
13.02-
26PhosphorylationIPEGSHQYELLKHAE
CCCCCHHHHHHHHHH
11.7926026062
35PhosphorylationLLKHAEATLGSGNLR
HHHHHHHHCCCCCCE
24.1326824392
38PhosphorylationHAEATLGSGNLRQAV
HHHHHCCCCCCEEEE
27.8526824392
74PhosphorylationQINMLYGTITEFCTE
HHHHHHHHHHHHHHH
15.92-
181PhosphorylationQEEAHLNTSFKHFIF
HHHHHHCCCHHHHHH
41.73-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
74TPhosphorylationKinaseMST2Q9JI10
Uniprot
146SPhosphorylationKinaseGSK3BP49841
PSP

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MOB1A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MOB1A_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MOB1A_MOUSE !!

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MOB1A_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry.";
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
Mol. Cell. Proteomics 8:904-912(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-35, AND MASSSPECTROMETRY.
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-35, AND MASSSPECTROMETRY.

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