UniProt ID | MOB1A_MOUSE | |
---|---|---|
UniProt AC | Q921Y0 | |
Protein Name | MOB kinase activator 1A | |
Gene Name | Mob1a | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 216 | |
Subcellular Localization | ||
Protein Description | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38 (By similarity).. | |
Protein Sequence | MSFLFSSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRQAVMLPEGEDLNEWIAVNTVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLGSKDR | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
2 | Acetylation | ------MSFLFSSRS ------CCCCCCCCC | 30.56 | - | |
2 | Phosphorylation | ------MSFLFSSRS ------CCCCCCCCC | 30.56 | 30352176 | |
6 | Phosphorylation | --MSFLFSSRSSKTF --CCCCCCCCCCCCC | 27.30 | 23984901 | |
7 | Phosphorylation | -MSFLFSSRSSKTFK -CCCCCCCCCCCCCC | 28.93 | 23984901 | |
9 | Phosphorylation | SFLFSSRSSKTFKPK CCCCCCCCCCCCCCC | 37.83 | 23984901 | |
10 | Phosphorylation | FLFSSRSSKTFKPKK CCCCCCCCCCCCCCC | 34.31 | 25266776 | |
12 | Phosphorylation | FSSRSSKTFKPKKNI CCCCCCCCCCCCCCC | 38.55 | 21454597 | |
23 | Phosphorylation | KKNIPEGSHQYELLK CCCCCCCCHHHHHHH | 13.02 | - | |
26 | Phosphorylation | IPEGSHQYELLKHAE CCCCCHHHHHHHHHH | 11.79 | 26026062 | |
35 | Phosphorylation | LLKHAEATLGSGNLR HHHHHHHHCCCCCCE | 24.13 | 26824392 | |
38 | Phosphorylation | HAEATLGSGNLRQAV HHHHHCCCCCCEEEE | 27.85 | 26824392 | |
74 | Phosphorylation | QINMLYGTITEFCTE HHHHHHHHHHHHHHH | 15.92 | - | |
181 | Phosphorylation | QEEAHLNTSFKHFIF HHHHHHCCCHHHHHH | 41.73 | - |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MOB1A_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MOB1A_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of MOB1A_MOUSE !! |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-35, AND MASSSPECTROMETRY. | |
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-35, AND MASSSPECTROMETRY. |